Abstract
Recent environmental problems caused by petroleum-based production of chemicals have accelerated the development of biorefineries for bio-based production of chemicals. Non-pathogenic microorganism, Corynebacterium glutamicum, has extensively been engineered and used as an industrial platform host strain for the commercial production of amino acids, such as l-lysine and L-glutamate. However, only recently has it been developed beyond its use for amino acid production. Recent advances in multiomics approaches, synthetic biology tools and metabolic engineering strategies have enabled the development of recombinant C. glutamicum into a versatile microbial cell factory for bio-based production of value-added platform chemicals and polymers by utilization of a broad range of biomass-derived sugars. In this review, we discuss the recent development of synthetic biology tools and techniques used for the enhancement of C. glutamicum’s ability to utilize renewable resources, specifically lignocellulosic biomass, for the production of platform chemicals with C4-C6 carbon backbone such as C4-isobutanol, 2,3-butanediol, C5-itaconic acid, 3-methyl-1-butanol, 2-methyl-1-butanol and C6-muconic acid.
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Acknowledgements
This work was supported by the Bio & Medical Technology Development Program MSIT through the NRF of Korea (NRF-2018M3A9H3020459), the Bio & Medical Technology Development Program of the National Research Foundation (NRF) & funded by the Korean government (MSIT) (NRF-2020M3A9I5037888), and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2020R1A5A1019631).
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Prof. Park is a professor at Department of Chemical Engineering and Materials Science, Ewha Womans University since 2017, Korea. Before joining Ewha Womans University, He worked for Department of Environmental Engineering and Energy, Myongji University as an assistant and associate professor (2012–2017), Chemical Biotechnology Research Center, Korea Research Institute of Chemical Technology (KRICT) as a senior research engineer (2009–2012), and Corporate R&D in LG Chem Research Park as a principal investigator of biomaterial research team (2003–2009). He received the BS. degree in chemical engineering from Seoul National University in 1997, and obtained the MS. and Ph.D degrees in chemical engineering from KAIST in 1999 and 2003, respectively. Currently, his research group focuses on the development of metabolically engineered microorganisms for the production of novel biopolymers, biochemicals and biofuels for biorefinery. As of April 2021, he has published over 100 scientific articles.
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Baritugo, KA., Son, J., Sohn, Y.J. et al. Recent progress in metabolic engineering of Corynebacterium glutamicum for the production of C4, C5, and C6 chemicals. Korean J. Chem. Eng. 38, 1291–1307 (2021). https://doi.org/10.1007/s11814-021-0788-2
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DOI: https://doi.org/10.1007/s11814-021-0788-2