Molecular mechanisms of thalidomide effectiveness on COVID-19 patients explained: ACE2 is a new ΔNp63α target gene Laura MonteonofrioIlaria VirdiaLuisa Guerrini Original Article Open access 18 September 2024
The role of circular RNA targeting IGF2BPs in cancer—a potential target for cancer therapy Xia LuoJiaxin ShiXiaofeng Jin Review 17 September 2024
Prefrontal cortex astrocytes in major depressive disorder: exploring pathogenic mechanisms and potential therapeutic targets Yarui PanLan XiangYongquan Wang Original Article 14 September 2024
Revising pathogenesis of AP1S1-related MEDNIK syndrome: a missense variant in the AP1S1 gene as a causal genetic lesion Marketa RackovaRafael MatteraKarolina Skvarova Kramarzova Original Article Open access 13 September 2024
Retraction Note: Endothelin-1 induces the transactivation of vascular endothelial growth factor receptor-3 and modulates cell migration and vasculogenic mimicry in melanoma cells Francesca SpinellaValentina CapraraAnna Bagnato Retraction Note 06 September 2024
Exosomal miR-21-5p derived from endometrial stromal cells promotes angiogenesis by targeting TIMP3 in ovarian endometrial cysts Liyuan SunYan ChengGuangmei Zhang Original Article 04 September 2024
Epigenetic profiles in blood and adipose tissue: identifying strong correlations in morbidly obese and non-obese patients Antonio Cantarero-CuencaAndres Gonzalez-JimenezFrancisco J. Tinahones Original Article 03 September 2024
Current treatment of Psoriasis triggered by Cytokine Storm and future immunomodulation strategies Geórgia de Carvalho BragaGabriel Rossi FranciscoMargarete Dulce Bagatini Review 30 August 2024
TRAP1 modulates mitochondrial biogenesis via PGC-1α/TFAM signalling pathway in colorectal cancer cells Giuseppina BrunoMichele PietrafesaMatteo Landriscina Original Article Open access 29 August 2024
Endoplasmic reticulum stress induces hepatic steatosis through interaction between PPARα and FoxO6 in vivo and in vitro Dae Hyun Kim Original Article Open access 28 August 2024
Protective role of M3 muscarinic acetylcholine receptor in indomethacin-induced small intestinal injury Yoko Igarashi-HisayoshiEikichi IharaYoshihiro Ogawa Original Article 22 August 2024 Pages: 1175 - 1186
New CRISPR/Cas9-based Fgfr2C361Y/+ mouse model of Crouzon syndrome exhibits skull and behavioral abnormalities Ying Ying YueChen-Zhi LaiXiao-Lei Jin Original Article 19 August 2024
New insights into the mechanisms and therapeutic strategies of chondrocyte autophagy in osteoarthritis Lujia TangJiatong DingHui Li Original Article 15 August 2024
β-Adrenergic blockade attenuates adverse adipose tissue responses after burn Shayahati BieerkehazhiAbdikarim AbdullahiMarc G. Jeschke Original Article 15 August 2024
WNT2B high‑expressed fibroblasts induce the fibrosis of IBD by promoting NK cells secreting IL-33 Yanling ChengShuzhe XiaoSitang Gong Original Article 13 August 2024
Oral pyrophosphate protects Abcc6-/- mice against vascular calcification induced by chronic kidney disease Elise BouderliqueJennifer KervadecEmmanuel Letavernier Original Article 13 August 2024
The caspase-inhibitor Emricasan efficiently counteracts cisplatin- and neomycin-induced cytotoxicity in cochlear cells Larissa NassauerJuliane W. SchottAxel Schambach Original Article Open access 07 August 2024 Pages: 1163 - 1174
Structure-based humanization of a therapeutic antibody for multiple myeloma Stephen F. MarinoOliver Daumke Original Article Open access 25 July 2024 Pages: 1151 - 1161
MicroRNAs role in telomere length maintenance and telomerase activity in tumor cells Stéfanne BortolettoEmanuelle Nunes-SouzaLuciane R. Cavalli Review 23 July 2024 Pages: 1089 - 1100
Effect of α7 nAChR-autophagy axis of deciduous tooth pulp stem cells in regulating IL-1β in the process of physiological root resorption of deciduous teeth Tiankai DiYujiang ChenLulu Wang Original Article 13 July 2024 Pages: 1135 - 1149
Neutrophil-secreted S100A8/A9 participates in fatty liver injury and fibrosis by promoting myofibroblast migration Na ChangYuran LiuLiying Li Original Article 12 July 2024 Pages: 1117 - 1133
Metformin improves cognitive dysfunction through SIRT1/NLRP3 pathway–mediated neuroinflammation in db/db mice Tian HuJun-Wen WeiShi-Jie Zhang Original Article 02 July 2024 Pages: 1101 - 1115
Aging- and alcohol-associated spatial transcriptomic signature in mouse acute pancreatitis reveals heterogeneity of inflammation and potential pathogenic factors Rachel R. TindallYuntao YangTien C. Ko Original Article Open access 28 June 2024 Pages: 1051 - 1061
The role and mechanism of heme oxygenase-1 in arrhythmias Huan-Huan LiuLei ZhangRu-Xing Wang Review 28 June 2024 Pages: 1001 - 1007
Molecular targets in bone cancer pain: a systematic review of inflammatory cytokines Jacinta RuivoIsaura TavaresDaniel H. Pozza Review Open access 28 June 2024 Pages: 1063 - 1088
PD-1/PD-L1 axis: implications in immune regulation, cancer progression, and translational applications Miguel A. OrtegaDiego Liviu BoaruMiguel A. Saez Review 27 June 2024 Pages: 987 - 1000
CircHIPK3/miR-124 affects angiogenesis in early-onset preeclampsia via CPT1A-mediated fatty acid oxidation Yanying WuJingrui HuangQi Li Original Article 21 June 2024 Pages: 1037 - 1049
Sex hormone binding globulin (SHBG) modulates mitochondrial dynamics in PPARγ-depleted equine adipose derived stromal cells Krzysztof MaryczBenita WiatrakLynda Bourebaba Original Article Open access 14 June 2024 Pages: 1015 - 1036
Exploring the role of tRNA-derived small RNAs (tsRNAs) in disease: implications for HIF-1 pathway modulation Qurui WangXiaowei YingShiwei Duan Review 08 June 2024 Pages: 973 - 985
Removal of GIT lesions and the role of impedance of the injection solution—an innovative approach to known methods Martina LösleK. E. GrundB. Duckworth-Mothes Original Article Open access 03 June 2024 Pages: 1009 - 1013
Tumor-derived extracellular vesicle proteins as new biomarkers and targets in precision oncology Haiyan LiaoCheng ZhangJing Gao Review Open access 30 May 2024 Pages: 961 - 971
Research progress and application of liver organoids for disease modeling and regenerative therapy Yang HuQiao GengDesong Kong Review Open access 28 May 2024 Pages: 859 - 874
Sphingosine is involved in PAPTP-induced death of pancreas cancer cells by interfering with mitochondrial functions Sameer H. PatelGregory C. WilsonErich Gulbins Original Article Open access 23 May 2024 Pages: 947 - 959
Mitochondria targeted esculetin administration improves insulin resistance and hyperglycemia-induced atherosclerosis in db/db mice Gajalakshmi SinguruSriravali PulipakaSrigiridhar Kotamraju Original Article 17 May 2024 Pages: 927 - 945
Loss-of-function mutation in DDX53 associated with hereditary spastic paraplegia-like disorder Xiangshu YuanYa WangMaofeng Wang Original Article 16 May 2024 Pages: 913 - 926
Non-invasive biomarkers prognostic of decompensation events in NASH cirrhosis: a systematic literature review Mattia AmorosoSalvador AugustinIsabella Gashaw Review Open access 16 May 2024 Pages: 841 - 858
Role and molecular mechanism of NOD2 in chronic non-communicable diseases Lingjun KongYanhua CaoYahui Zhang Review 14 May 2024 Pages: 787 - 799
PCDH11X mutation as a potential biomarker for immune checkpoint therapies in lung adenocarcinoma Manjiao LiuMeijia YangJie Zhao Original Article 13 May 2024 Pages: 899 - 912
Blocking H1R signal aggravates atherosclerosis by promoting inflammation and foam cell formation Baoling ZhuYi YangXiangdong Yang Original Article 11 May 2024 Pages: 887 - 897
Mechanism of efferocytosis in atherosclerosis Li-Xia ShuLiu-li CaoShu-Zhi Wang Review 10 May 2024 Pages: 831 - 840
Myeloid-derived growth factor ameliorates dextran sodium sulfate-induced colitis by regulating macrophage polarization Yang YangConghui ZhaoZhenhua Gao Original Article Open access 02 May 2024 Pages: 875 - 886
Mechanistic complement of autosomal dominant polycystic kidney disease: the role of aquaporins Qiumei LanJie LiBo Yang Review 26 April 2024 Pages: 773 - 785
Analysis of the action mechanisms and targets of herbal anticonvulsants highlights opportunities for therapeutic engagement with refractory epilepsy Sobia TabassumSusan ShorterSaak V. Ovsepian Review Open access 24 April 2024 Pages: 761 - 771
The role of annexins in central nervous system development and disease Zachary B. White IISindhu NairMarkus Bredel Review Open access 19 April 2024 Pages: 751 - 760
The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases Antero Salminen Review Open access 11 April 2024 Pages: 733 - 750
Metabolomic profiling of maternal plasma identifies inverse associations of acetate and urea with anti-SARS-CoV-2 antibody titers following COVID-19 vaccination during pregnancy An-Shine ChaoChiao-Yun LinChih-Yung Chiu Original Article 03 April 2024 Pages: 819 - 830
Abnormal protein SUMOylation in liver disease: novel target for therapy Yanfang YangFuxun Yu Review 03 April 2024 Pages: 719 - 731
Pathogenic effects of Leu200Pro and Arg387His VRK1 protein variants on phosphorylation targets and H4K16 acetylation in distal hereditary motor neuropathy Aurora Campos-DíazPatricia Morejón-GarcíaPedro A. Lazo Original Article Open access 30 March 2024 Pages: 801 - 817
Ischemic stroke and diabetes: a TLR4-mediated neuroinflammatory perspective Thura Tun Oo Review 28 March 2024 Pages: 709 - 717
An Hsp70 promoter–based mouse for heat shock–induced gene modulation Hangang ChenYangli XieFengtao Luo Original Article 16 March 2024 Pages: 693 - 707