Collection
Prodrugs
- Submission status
- Open
- Open for submission from
- 01 January 2021
- Submission deadline
- Ongoing
The following articles were selected by the editors as some of the best research recently published in Medicinal Chemistry Research on prodrugs. This list is current to 1 October, 2023.
Articles (36 in this collection)
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Combination with a FtsZ inhibitor potentiates the in vivo efficacy of oxacillin against methicillin-resistant Staphylococcus aureus
Authors (first, second and last of 6)
- Malvika Kaul
- Edgar Ferrer-González
- Daniel S. Pilch
- Content type: Original Research
- Published: 05 September 2022
- Pages: 1705 - 1715
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Chemical and biological aspects of posaconazole as a classic antifungal agent with non-classical properties: highlighting a tetrahydrofuran-based drug toward generation of new drugs
Authors
- Sakineh Dadashpour
- Elham Ghobadi
- Saeed Emami
- Content type: Review Article
- Published: 19 May 2022
- Pages: 833 - 850
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Synthesis and evaluation of new sartan derivatives
Authors (first, second and last of 9)
- Bertsetseg Dalaijargal
- Le Mi
- Zhi-Long Chen
- Content type: Original Research
- Published: 06 May 2022
- Pages: 1003 - 1010
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Synthesis and anticancer activity of Boc-Gly-Pro dipeptide-annonaceous acetogenin prodrugs targeting fibroblast activation protein or other hydrolytic enzymes
Authors (first, second and last of 5)
- Jing-Fang Shi
- Ping Wu
- Zi-Hua Jiang
- Content type: Original Research
- Published: 24 February 2022
- Pages: 605 - 616
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Synthesis and antitumor activity of novel silibinin and 2,3-dehydrosilybin derivatives with carbamate groups
Authors
- Qiuchan Wu
- Jiang Zeng
- Jinfu Dong
- Content type: Original Research
- Published: 15 February 2022
- Pages: 533 - 544
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An insight into prodrug strategy for the treatment of Alzheimer’s disease
Authors (first, second and last of 6)
- Neha V. Bhilare
- Vinayak S. Marulkar
- Pramodkumar J. Shirote
- Content type: Review Article
- Published: 15 February 2022
- Pages: 383 - 399
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Synthesis and biological evaluation of prodrugs for nitroreductase based 4-β-amino-4′-Demethylepipodophyllotoxin as potential anticancer agents
Authors
- Zheng-Rong Wu
- Wei Deng
- Dian He
- Content type: Original Research
- Published: 24 January 2022
- Pages: 1099 - 1108
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Conjugates of Tetramethylpyrazine’ metabolites and amino acid as potential antiplatelet agents
Authors (first, second and last of 11)
- Yongxi Dong
- Shuxia Wu
- Li Dong
- Content type: Original Research
- Published: 12 November 2021
- Pages: 75 - 84
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Innovation in the discovery of the HIV-1 attachment inhibitor temsavir and its phosphonooxymethyl prodrug fostemsavir
Authors
- Tao Wang
- John F. Kadow
- Nicholas A. Meanwell
- Content type: Review Article
- Open Access
- Published: 28 September 2021
- Pages: 1955 - 1980
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Phosphoryl prodrugs: characteristics to improve drug development
Authors
- Samuel A. Kirby
- Cynthia S. Dowd
- Content type: Review Article
- Published: 23 July 2021
- Pages: 207 - 216
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Design, synthesis, and evaluation of potential carbamate prodrugs of 5′-methylthioadenosine (MTA)
Authors
- Ashwini Sadanand Ranade
- Joseph R. Bertino
- Longqin Hu
- Content type: Original Research
- Published: 29 April 2021
- Pages: 1358 - 1365
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Synthesis and biological evaluation of pyrrolidine-functionalized nucleoside analogs
Authors (first, second and last of 8)
- Uthpala Seneviratne
- Susith Wickramaratne
- Natalia Y. Tretyakova
- Content type: Original Research
- Published: 03 February 2021
- Pages: 483 - 499
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Phosphoramidate conjugates of 3′-azido-3′-deoxythymidine glycerolipid derivatives and amino acid esters: synthesis and anti-HIV activity
Authors (first, second and last of 5)
- Elizaveta S. Darnotuk
- Andrei E. Siniavin
- Natal’ya S. Shastina
- Content type: Original Research
- Published: 05 January 2021
- Pages: 664 - 671
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Synthesis, biological evaluation and molecular docking studies of Combretastatin A-4 phosphoramidates as novel anticancer prodrugs
Authors (first, second and last of 7)
- Shaowu Zhang
- Tang Li
- Fanhong Wu
- Content type: Original Research
- Published: 26 September 2020
- Pages: 2192 - 2202
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Synthesis and evaluation of new peptide-linked doxorubicin conjugates as prodrugs activated by prostate-specific antigen
Authors
- Herve Aloysius
- Longqin Hu
- Content type: Original Research
- Published: 04 June 2020
- Pages: 1280 - 1299
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Synthesis and evaluation of new 4-peptidamido-2-fluorobenzyl phosphoramide mustard conjugates as prodrugs activated by prostate-specific antigen
Authors
- Herve Aloysius
- Longqin Hu
- Content type: Original Research
- Published: 03 June 2020
- Pages: 1264 - 1279
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Synthesis and biological evaluation of N-alkyl-1,4-dihydroquinoline prodrugs of scutellarin methyl ester as neuroprotective agents
Authors (first, second and last of 6)
- Yongxi Dong
- Li Dong
- Chunhua Qiao
- Content type: Original Research
- Published: 15 February 2018
- Pages: 1111 - 1121
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Novel adefovir mono L-amino acid ester, mono bile acid ester derivatives: Design, synthesis, biological evaluation, and molecular docking study
Authors (first, second and last of 13)
- Ya Chen
- Wen Zheng Zhang
- Yong-Jun Li
- Content type: Original Research
- Published: 17 April 2017
- Pages: 1812 - 1821
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Ethyl phosphoramidates of acyclovir: design, synthesis, molecular docking (HN Protein), and evaluation of antiviral and antioxidant activities
Authors (first, second and last of 7)
- Subba Rao Devineni
- Madhava Golla
- Naga Raju Chamarthi
- Content type: Original Research
- Published: 02 March 2017
- Pages: 999 - 1009
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Prostaglandin analogues: current treatment option for glaucoma
Authors (first, second and last of 4)
- Poonam Piplani
- Deepali Aggarwal
- Lovneet Saini
- Content type: Review Article
- Published: 07 April 2016
- Pages: 1031 - 1048
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Synthesis, crystal structure, biological evaluation, electronic aspects of hydrogen bonds, and QSAR studies of some new N-(substituted phenylurea) diazaphosphore derivatives as anticancer agents
Authors (first, second and last of 4)
- Niloufar Dorosti
- Bahram Delfan
- Ali Asghar Ebrahimi Valmoozi
- Content type: Original Research
- Published: 18 February 2016
- Pages: 769 - 789
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Synthesis and pharmacological evaluation of mutual prodrugs of aceclofenac with quercetin, vanillin and l-tryptophan as gastrosparing NSAIDS
Authors (first, second and last of 6)
- Arun Rasheed
- G. Lathika
- Nija Balan
- Content type: Original Research
- Published: 23 September 2015
- Pages: 70 - 82
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Synthesis, cyclooxygenase inhibition, and anti-inflammatory evaluation of novel diarylheterocycles with a central pyrazole, pyrazoline, or pyridine ring
Authors (first, second and last of 4)
- Khaled R. A. Abdellatif
- Eman K. A. Abdelall
- Gehan M. Kamel
- Content type: Original Research
- Published: 28 January 2015
- Pages: 2632 - 2644
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Potential utility of adenosine 5′-ester prodrugs to enhance its plasma half-life: synthesis and molecular docking studies
Authors
- Eduardo Hernández-Vázquez
- Victoria Chagoya
- Content type: Original Research
- Published: 16 November 2014
- Pages: 2325 - 2335
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l-Amino acid carbamate prodrugs of scutellarin: synthesis, physiochemical property, Caco-2 cell permeability, and in vitro anti-oxidative activity
Authors (first, second and last of 13)
- Yu-Feng Cha
- Shun Zhang
- Yong-Lin Wang
- Content type: Original Research
- Published: 12 November 2014
- Pages: 2238 - 2246
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Novel ibuprofen prodrugs with improved pharmacokinetics and non-ulcerogenic potential
Authors (first, second and last of 6)
- Valmik D. Dhakane
- Hemant V. Chavan
- Babasaheb P. Bandgar
- Content type: Original Research
- Published: 11 June 2013
- Pages: 503 - 517
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Synthesis, characterization, in vitro hydrolysis and pharmacodynamic profiles of potential novel mutual prodrugs of N-(2,3-xylyl anthranilic acid)
Authors
- Sucheta Ohlan
- Sanju Nanda
- Dharam Pal Pathak
- Content type: Original Research
- Published: 07 February 2013
- Pages: 5120 - 5128
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Evaluation of mefenamic acid mutual prodrugs
Authors
- Kamal Shah
- Sushant K. Shrivastava
- Pradeep Mishra
- Content type: Original Research
- Published: 13 March 2012
- Pages: 70 - 77
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CytochromeP450 isoenzyme specificity in the metabolism of anti-malarial biguanides: molecular docking and molecular dynamics analyses
Authors
- Dhilon S. Patel
- M. Ramesh
- Prasad V. Bharatam
- Content type: Original Research
- Published: 11 January 2012
- Pages: 4274 - 4289
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Synthesis, characterization and in vitro hydrolysis studies of ester and amide prodrugs of dexibuprofen
Authors
- Zaman Ashraf
- Muhammad Imran
- Shahid Amin
- Content type: Original Research
- Published: 17 November 2011
- Pages: 3361 - 3368
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Synthesis and biological evaluation of ester derivatives of indomethacin as selective COX-2 inhibitors
Authors (first, second and last of 4)
- M. Arockia Babu
- Rakesh Shukla
- S. G. Kaskhedikar
- Content type: Original Research
- Published: 16 July 2011
- Pages: 2223 - 2228
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Design, synthesis and evaluation of novel indomethacin–flavonoid mutual prodrugs as safer NSAIDs
Authors
- Shruti Sawraj
- Tilak R. Bhardawaj
- Pritam D. Sharma
- Content type: Original Research
- Published: 08 June 2010
- Pages: 687 - 694
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Synthesis and evaluation of novel prodrugs of naproxen
Authors (first, second and last of 5)
- Prabodh Chander Sharma
- Sonia Yadav
- Sandeep Jain
- Content type: Original Research
- Published: 30 May 2010
- Pages: 648 - 655
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The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity
Authors (first, second and last of 5)
- Zrinka Rajić
- Dimitra Hadjipavlou-Litina
- Branka Zorc
- Content type: Original Research
- Published: 03 February 2010
- Pages: 210 - 219
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Substituted aminoalcohol ester analogs of indomethacin with reduced toxic effects
Authors (first, second and last of 4)
- Parmeshwari K. Halen
- Kewal K. Chagti
- Mange Ram Yadav
- Content type: Original Research
- Published: 21 July 2007
- Pages: 101 - 111