Overview
Covers the biogenesis and composition of bacterial membrane vesicles
Highlights the various functions extracellular vesicles have in bacterial ecology and pathogenesis
Outlines new avenues in applied microbiology and the development of new vaccines and therapies
Discusses the roles of membrane delivery vehicles in bacterial communities and host interactions
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About this book
This book focuses on the multitude of functions bacterial membrane vesicles perform in bacterial ecology and pathogenesis as well as in emerging medical and biotechnological applications. Both Gram-negative and Gram-positive bacteria produce membrane-bound nanostructures, known as membrane vesicles, which have a range of functions that include serving as delivery vehicles, providing a means of communication over both spatial and temporal scales, and contributing to bacterial survival and evolution. Topics covered in this book range from the biogenesis and composition of bacterial membrane vesicles to their abundance and biological roles in microbial ecosystems, such as marine environments. In the individual chapters, the involvement of bacterial membrane vesicles in host-pathogen interactions, promoting virulence and in facilitating the establishment of infection is explained. In addition, current knowledge regarding membrane vesicles produced by commensal bacteria and their role in the maturation of the host immune system, as well as the therapeutic potential of bacterial membrane vesicles as delivery systems and innovative nanotechnology-based therapeutics are discussed.
This work appeals to a wide readership of students and researchers interested in microbial ecology, mechanism underlying pathogenesis and new avenues in applied microbiology and nanotechnology.
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Keywords
- Outer Membrane Vesicles
- OMVs release internalization
- Gram-negative bacteria vesicles
- MVs virulence factors
- pathogenesis immune modulation
- extracellular milieu
- periplasmic content
- microbial interactions
- bacterial communities
- vaccine development
- membrane-bound material
- microvesicles, exosomes
- virus-like particles
Table of contents (10 chapters)
Editors and Affiliations
About the editors
Associate Professor Maria Kaparakis-Liaskos
Associate Professor Maria Kaparakis-Liaskos is Head of the Host-pathogen Interactions and Bacterial Membrane Vesicles Laboratory at La Trobe University, Australia. She is also the Deputy Director of the La Trobe Research Centre for Extracellular Vesicles. Her recent research activities focus on understanding the cellular and molecular mechanisms of host-pathogen interactions with particular focus on bacterial membrane vesicles.
Associate Professor Kaparakis-Liaskos obtained her PhD from the Department of Microbiology and Immunology at the University of Melbourne in Australia in 2005. She then undertook post-doctoral studies at Monash University, working on innate immune responses to Helicobacter pylori and bacterial outer membrane vesicles. She then headed a research group at the Hudson Institute of Medical Research, Australia during which time she identified the mechanisms whereby OMVs were detected by NOD1 and were degraded by autophagy. In 2016, she joined La Trobe University in Melbourne, Australia, where her research is supported by the Australian Research Council (ARC), the National Health and Medical Research Council (NHMRC) and the Victorian Endowment for Science Knowledge and Innovation (veski).
Professor Thomas A. Kufer
Professor Thomas Kufer is head of the Department of Immunology at the University of Hohenheim, Stuttgart, Germany. His primary research interests are focused on understanding the functions of NLR proteins in host-pathogen interactions, immunity and inflammation.
Professor Kufer obtained his PhD (Dr. rer. nat.) in Cell Biology from the Ludwig-Maximilians University of Munich in 2004. He then undertook post-doctoral studies in the laboratories of Dana Philpott and Philippe Sansonetti in the Pasteur Institute in Paris working on the intracellular pattern recognition receptors NOD1 and NOD2 in the context of Shigella flexneri infection. Subsequently he headed a junior research group funded by the German Research Foundation (DFG) at the Institute of Medical Microbiology, Immunology and Hygiene at University of Cologne in Germany working on innate immune responses mediated by NLR proteins. In 2014 he was recruited at the University of Hohenheim as professor for immunology.
Bibliographic Information
Book Title: Bacterial Membrane Vesicles
Book Subtitle: Biogenesis, Functions and Applications
Editors: Maria Kaparakis-Liaskos, Thomas A. Kufer
DOI: https://doi.org/10.1007/978-3-030-36331-4
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2020
Hardcover ISBN: 978-3-030-36330-7Published: 01 April 2020
Softcover ISBN: 978-3-030-36333-8Published: 01 April 2021
eBook ISBN: 978-3-030-36331-4Published: 31 March 2020
Edition Number: 1
Number of Pages: XII, 251
Number of Illustrations: 5 b/w illustrations, 21 illustrations in colour
Topics: Microbiology, Membrane Biology, Microbial Ecology