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Microfluidic Systems for Cancer Diagnosis

  • Book
  • © 2023

Overview

Editors:
  1. Jose L. Garcia-Cordero

    1. Institute of Human Biology (IHB), Roche Pharma Research and Early Development, Roche Innovation Center, Basel, Switzerland

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  2. Alexander Revzin

    1. Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge techniques
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2679)

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About this book

This detailed volume explores recent developments in microfluidics technologies for cancer diagnosis and monitoring. The book is divided into two sections that delve into techniques for liquid biopsy for cancer diagnosis and platforms for precision oncology or personalized medicine in order to create effective patient avatars for testing anti-cancer drugs. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and practical, Microfluidic Systems for Cancer Diagnosis serves as an ideal guide that will be helpful to either replicate the construction of microfluidic devices specifically developed for cancer diagnosis or to catalyze development of new and better cancer diagnostic devices.

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Table of contents (22 protocols)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Lateral Filter Array Microfluidic Devices for Detecting Circulating Tumor Cells

    • Kangfu Chen, Thomas J. George, Z. Hugh Fan
    Pages 1-13

  3. Circulating Tumor Cell Cluster Sorting by Size and Asymmetry

    • Sam H. Au
    Pages 15-23

  4. Digital Microfluidics with an On-Chip Drug Dispenser for Single or Combinational Drug Screening

    • Caiwei Li, Jiao Zhai, Yanwei Jia
    Pages 25-39

  5. Affinity-Based Microfluidics Combined with Atomic Force Microscopy for Isolation and Nanomechanical Characterization of Circulating Tumor Cells

    • Muhammedin Deliorman, Ayoub Glia, Mohammad A. Qasaimeh
    Pages 41-66

  6. Capture and Selective Release of Viable Circulating Tumor Cells

    • Xilal Y. Rima, Jingjing Zhang, Eduardo Reátegui
    Pages 67-81

  7. Single-Response Electronic Tongue and Machine Learning Enable the Multidetermination of Extracellular Vesicle Biomarkers for Cancer Diagnostics Without Recognition Elements

    • Caroline Y. N. Nicoliche, Giulia S. da Silva, Leticia Gomes-de-Pontes, Gabriel R. Schleder, Renato S. Lima
    Pages 83-94

  8. Functional Interrogation of Ca2+ Signals in Human Cancer Cells In Vitro and Ex Vivo by Fluorescent Microscopy and Molecular Tools

    • Chenyu Liang, Miao Huang, Mai Tanaka, Suzanne Lightsey, Madison Temples, Sharon E. Lepler et al.
    Pages 95-125

  9. Microfluidic Protocols for the Assessment of Anticancer Therapies in 3D Tumor-Stromal Cocultures

    • Karla Paterson, Michele Zagnoni
    Pages 127-139

  10. A Microfluidic Approach for Enrichment and Single-Cell Characterization of Circulating Tumor Cells from Peripheral Blood

    • Payar Radfar, Lin Ding, Hamidreza Aboulkheyr Es, Majid Ebrahimi Warkiani
    Pages 141-150

  11. Rapid On-Site Evaluation (ROSE): A Microfluidic Approach

    • Filipe Marques, Janosch Hauser, Niclas Roxhed
    Pages 151-161

  12. Microfluidic Acoustic Method for High Yield Extraction of Cell-Free DNA in Low-Volume Plasma Samples

    • Alvaro J. Conde, Ieva Keraite, Nicholas R. Leslie, Maïwenn Kersaudy-Kerhoas
    Pages 163-180

  13. Isolation of Extracellular Vesicles by a Microfluidic Platform to Diagnose and Monitor Pancreatic Cancer

    • María Sancho-Albero, Victor Sebastián
    Pages 181-191

  14. High-Throughput Separation and Enrichment of Rare Malignant Tumor Cells from Large-Volume Effusions by Inertial Microfluidics

    • Chen Ni, Zhixian Zhu, Zheng Zhou, Nan Xiang
    Pages 193-206

  15. SAIF: Label-Free Separation of Circulating Tumor Cells Using a Self-Amplified Inertial Focusing Microfluidic Chip

    • Aynur Abdulla, Xianting Ding
    Pages 207-218

  16. Patient-Specific Microfluidic Cancer Spheroid Cultures for Testing Cancer Therapies

    • Daheui Choi, Alan M. Gonzalez-Suarez, Daniel D. Billadeau, Wen Wee Ma, Gulnaz Stybayeva, Alexander Revzin
    Pages 219-231

  17. Isolation of Cancer Cells from Liquid Biopsies Using 3D-Printed Affinity Devices

    • Yijia Yang, Kitiara Griffin, Sarah Villareal, Dimitri Pappas
    Pages 233-240

  18. A Microfluidic SERS Assay to Characterize the Phenotypic Heterogeneity in Cancer-Derived Small Extracellular Vesicles

    • Jing Wang, Matt Trau, Alain Wuethrich
    Pages 241-253

  19. Cluster-Wells: A Technology for Routine and Rapid Isolation of Extremely Rare Circulating Tumor Cell Clusters from Unprocessed Whole Blood

    • Mert Boya, A. Fatih Sarioglu
    Pages 255-268

  20. Secretion Function Analysis of Ex Vivo Immune Cells in an Integrated Microfluidic Device

    • Roberto Rodriguez-Moncayo, Jose L. Garcia-Cordero
    Pages 269-285
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Editors and Affiliations

  • Institute of Human Biology (IHB), Roche Pharma Research and Early Development, Roche Innovation Center, Basel, Switzerland

    Jose L. Garcia-Cordero

  • Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, USA

    Alexander Revzin

Bibliographic Information

  • Book Title: Microfluidic Systems for Cancer Diagnosis

  • Editors: Jose L. Garcia-Cordero, Alexander Revzin

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-3271-0

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2023

  • Hardcover ISBN: 978-1-0716-3270-3Published: 11 June 2023

  • Softcover ISBN: 978-1-0716-3273-4Published: 11 June 2024

  • eBook ISBN: 978-1-0716-3271-0Published: 10 June 2023

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XIII, 324

  • Number of Illustrations: 1 b/w illustrations

  • Topics: Cancer Research, Analytical Chemistry, Biotechnology, Nanotechnology and Microengineering

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