Overview
- Provides cutting-edge research in this discipline
- Includes contributions from the TERMIS community
- Addresses both clinical practitioners and researchers in academia
- Written by international experts in the field
Part of the book series: Reference Series in Biomedical Engineering (RSBE)
Part of the book sub series: Tissue Engineering and Regeneration (TIENRE)
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About this book
This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.
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Bibliographic Information
Book Title: Cell Engineering and Regeneration
Editors: Jeffrey M. Gimble, Darja Marolt Presen, Richard O. C. Oreffo, Susanne Wolbank, Heinz Redl
Series Title: Reference Series in Biomedical Engineering
DOI: https://doi.org/10.1007/978-3-319-37076-7
Publisher: Springer Cham
eBook Packages: Springer Reference Engineering, Reference Module Computer Science and Engineering
eBook ISBN: 978-3-319-37076-7Due: 11 September 2022
Series ISSN: 2731-0493
Series E-ISSN: 2731-0507
Number of Illustrations: 20 b/w illustrations
Topics: Biomedical Engineering and Bioengineering, Biomaterials, Regenerative Medicine/Tissue Engineering, Biological and Medical Physics, Biophysics