Abstract
Scaffolding materials are three-dimensional (3D) structures derived from existing tissue (e.g., decellularized bone, collagen-based) or de novo synthesized (e.g., titanium, polycaprolactone), supporting cell attachment, proliferation, and differentiation. Despite the increasing number of biocompatible templates, few of them represent a gold standard treatment for regenerative medicine. This drives the development of advanced materials with increased performance. Nowadays, the diversification of isolation and/or fabrication methods offers a wide potential to design specific structures with tailored properties. In this chapter, we present the main existing strategies to customize 3D material properties toward optimized tissue regeneration. The possibility to tune the composition/architecture as well as to functionalize materials with bioactive elements will be discussed.
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This work was supported by the AO Foundation (grant S-15-25B) and the Knut and Alice Wallenberg Foundation.
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Bourgine, P.E. (2019). Hard Material Modulation for (Skeletal) Tissue Engineering Purposes. In: Gimble, J., Marolt, D., Oreffo, R., Redl, H., Wolbank, S. (eds) Cell Engineering and Regeneration. Reference Series in Biomedical Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-319-37076-7_30-1
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