Generative models for synthetic data generation: application to pharmacokinetic/pharmacodynamic data Yulun JiangAlberto García-DuránNadia Terranova ORIGINAL PAPER 27 August 2024
A review of the physiological effects of microgravity and innovative formulation for space travelers Jey Kumar PachiyappanManali PatelGowthamarajan Kuppusamy Review Paper 20 August 2024
Visual predictive check of longitudinal models and dropout Chuanpu HuAnna G. KondicAmit Roy Original Paper 18 August 2024
General quasi-equilibrium multivalent binding model to study diverse and complex drug-receptor interactions of biologics Chee M. NgRobert J. Bauer Original Paper 17 August 2024
Time Scale Calculus: a new approach to multi-dose pharmacokinetic modeling José Ricardo Arteaga-BejaranoSantiago Torres Original Paper Open access 25 July 2024
A quantitative modeling framework to understand the physiology of the hypothalamic-pituitary-adrenal axis and interaction with cortisol replacement therapy Davide BindelliniRobin MicheletCharlotte Kloft Original Paper Open access 08 July 2024
Likelihood comparisons in bounded outcome score analysis must be internally consistent Chuanpu Hu Commentary 05 July 2024
Mixed effect estimation in deep compartment models: Variational methods outperform first-order approximations Alexander JanssenFrank C. Bennisfor the OPTI-CLOT study group SYMPHONY consortium Original Paper Open access 04 July 2024
pyDarwin machine learning algorithms application and comparison in nonlinear mixed-effect model selection and optimization Xinnong LiMark SaleLiang Zhao Original Paper Open access 28 June 2024
An asymptotic description of a basic FcRn-regulated clearance mechanism and its implications for PBPK modelling of large antibodies Csaba B. KátaiShepard J. SmithlineJeroen Elassaiss-Schaap Original Paper 24 June 2024
Advancing cancer drug development with mechanistic mathematical modeling: bridging the gap between theory and practice Alexander KuleszaClaire CoutyYanguang Cao Review Paper 21 June 2024
Virtual clinical trials via a QSP immuno-oncology model to simulate the response to a conditionally activated PD-L1 targeting antibody in NSCLC Alberto IppolitoHanwen WangAleksander S. Popel Original Paper Open access 10 June 2024
Generation of realistic virtual adult populations using a model-based copula approach Yuchen GuoTingjie GuoJ. G. Coen van Hasselt Original Paper Open access 06 June 2024
Correction: Model-based comparison of subcutaneous versus sublingual apomorphine administration in the treatment of motor fluctuations in Parkinson’s disease Azmi NasserRoberto GomeniJonathan Rubin Correction Open access 30 May 2024 Pages: 395 - 395
Authors’ response to letter to editor Euibeom ShinYifan YuMurali Ramanathan Correspondence 27 May 2024 Pages: 305 - 305
ChatGPT and Gemini large language models for pharmacometrics with NONMEM: comment Hinpetch DaungsupawongViroj Wiwanitkit Correspondence 25 May 2024 Pages: 303 - 304
Correction: Oral docetaxel plus encequidar – a pharmacokinetic model and evaluation against IV docetaxel David WangChris JacksonStephen Duffull Correction Open access 14 May 2024 Pages: 353 - 353
A quantitative systems pharmacology model of plasma kallikrein-kinin system dysregulation in hereditary angioedema Dan SextonHoa Q. NguyenAndy Z. X. Zhu Original Paper Open access 11 May 2024
Note on importance of correct stoichiometric assumptions for modeling of monoclonal antibodies Leonid GibianskyEkaterina Gibiansky Original Paper 03 May 2024 Pages: 307 - 317
Translational two-pore PBPK model to characterize whole-body disposition of different-size endogenous and exogenous proteins Shufang LiuYingyi LiDhaval K. Shah Original Paper 01 May 2024
Evaluation of ChatGPT and Gemini large language models for pharmacometrics with NONMEM Euibeom ShinYifan YuMurali Ramanathan Original Paper 24 April 2024 Pages: 187 - 197
Target-mediated drug disposition model for drugs with N > 2 binding sites that bind to a target with one binding site Leonid GibianskyChee M. NgEkaterina Gibiansky Original Paper 19 April 2024
A systematic evaluation of population pharmacokinetic models for polymyxin B in patients with liver and/or kidney dysfunction Xueyong LiYu ChengHongqiang Qiu Original Paper 16 April 2024
Five multivariate Duchenne muscular dystrophy progression models bridging six-minute walk distance and MRI relaxometry of leg muscles Deok Yong YoonMichael J. Danielsthe DMD MR Biomarker Steering Committee Original Paper 12 April 2024
Impact of covariate model building methods on their clinical relevance evaluation in population pharmacokinetic analyses: comparison of the full model, stepwise covariate model (SCM) and SCM+ approaches Morgane PhilippSimon BuatoisFrance Mentré Original Paper 09 April 2024
Model-based comparison of subcutaneous versus sublingual apomorphine administration in the treatment of motor fluctuations in Parkinson’s disease Azmi NasserRoberto GomeniJonathan Rubin Original Paper Open access 05 April 2024 Pages: 385 - 393
Docetaxel, cyclophosphamide, and epirubicin: application of PBPK modeling to gain new insights for drug-drug interactions Tongtong LiSufeng ZhouFeng Shao Original Paper 30 March 2024 Pages: 367 - 384
Longitudinal modeling of efficacy response in patients with lupus nephritis receiving belimumab Monica SimeoniShuying YangRichard Dimelow Original Paper Open access 29 March 2024 Pages: 289 - 301
On inductive biases for the robust and interpretable prediction of drug concentrations using deep compartment models Alexander JanssenFrank C. Bennisfor the OPTI-CLOT Study Group and SYMPHONY Consortium Original Paper Open access 26 March 2024 Pages: 355 - 366
Maximum a posteriori Bayesian methods out-perform non-compartmental analysis for busulfan precision dosing Jasmine H. HughesJanel Long-BoyleRon J. Keizer Original Paper Open access 23 March 2024 Pages: 279 - 288
Oral docetaxel plus encequidar – A pharmacokinetic model and evaluation against IV docetaxel David WangChris JacksonStephen Duffull Original Paper Open access 19 March 2024 Pages: 335 - 352
Predicting efficacy assessment of combined treatment of radiotherapy and nivolumab for NSCLC patients through virtual clinical trials using QSP modeling Miriam SchirruHamza CharefFahima Nekka Original Paper 17 March 2024 Pages: 319 - 333
An industry perspective on current QSP trends in drug development Lourdes Cucurull-Sanchez Original Paper Open access 05 March 2024
Employing zero-inflated beta distribution in an exposure-response analysis of TYK2/JAK1 inhibitor brepocitinib in patients with plaque psoriasis Nikolaos TsamandourasRuolun QiuTimothy Nicholas Original Paper Open access 03 March 2024 Pages: 265 - 277
Fourteenth American Conference on Pharmacometrics (ACoP14) – Innovation and Diversity: Redefining Pharmacometrics Sihem Ait-Oudhia Editorial 28 February 2024 Pages: 95 - 100
Subgroup identification-based model selection to improve the predictive performance of individualized dosing Hiie SoeorgRiste KalameesTuuli Metsvaht Original Paper 24 February 2024 Pages: 253 - 263
A minimal physiologically based pharmacokinetic model to study the combined effect of antibody size, charge, and binding affinity to FcRn/antigen on antibody pharmacokinetics Krutika PatidarNikhil PillaiPanteleimon D. Mavroudis Original Paper Open access 24 February 2024
Thoughts on plagiarism and the case against Claudine Gay Peter L. Bonate Editorial 15 February 2024 Pages: 1 - 4
Population pharmacokinetics of the dual endothelin receptor antagonist aprocitentan in subjects with or without essential or resistant hypertension Janneke M. BrusseePatricia N. SidhartaAndreas Krause Original Paper 08 February 2024 Pages: 243 - 252
A population pharmacokinetics model of balovaptan to support dose selection in adult and pediatric populations Franziska Schaedeli StarkClarisse ChavanneHanna E. Silber Baumann Original Paper Open access 03 February 2024 Pages: 227 - 242
Correction: External control arms for rare diseases: building a body of supporting evidence Artak KhachatryanStephanie H ReadTerri Madison Correction Open access 19 January 2024 Pages: 93 - 93
How drug onset rate and duration of action affect drug forgiveness Elias D. ClarkSean D. Lawley Original Paper 10 January 2024 Pages: 213 - 226
Semi-mechanistic modeling of resistance development to β-lactam and β-lactamase-inhibitor combinations Sebastian T. TandarLinda B.S. AulinJ. G. Coen van Hasselt Original Paper 26 November 2023 Pages: 199 - 211
Comparison of monoclonal antibody disposition predictions using different physiologically based pharmacokinetic modelling platforms Pieter-Jan De SutterElke GasthuysAn Vermeulen Original Paper 12 November 2023
Evaluation of prompt engineering strategies for pharmacokinetic data analysis with the ChatGPT large language model Euibeom ShinMurali Ramanathan Original Paper 11 November 2023 Pages: 101 - 108
Expansion of platform physiologically-based pharmacokinetic model for monoclonal antibodies towards different preclinical species: cats, sheep, and dogs Hsien-Wei HuangShengjia WuDhaval K. Shah Original Paper 10 November 2023
Characterization of anti-drug antibody dynamics using a bivariate mixed hidden-markov model by nonlinear-mixed effects approach Ari BrekkanRocío Lledo-GarciaElodie L. Plan Original Paper Open access 09 November 2023 Pages: 65 - 75
Explaining in-vitro to in-vivo efficacy correlations in oncology pre-clinical development via a semi-mechanistic mathematical model Heinrich J. HuberHitesh B. Mistry Original Paper Open access 06 November 2023 Pages: 169 - 185
Rare oncology therapeutics: review of clinical pharmacology package of drug approvals (2019–2023) by US FDA, best practices and recommendations Amitava MitraJong Bong LeeRajesh Krishna Review Paper 04 November 2023 Pages: 475 - 493
Learning pharmacometric covariate model structures with symbolic regression networks Ylva WahlquistJesper SundellKristian Soltesz Original Paper Open access 21 October 2023 Pages: 155 - 167