Overview
- Shows how sugar chains are critically involved in malignant phenotypes of cancers
- Presents a variety of modes by which sugar chains modulate cell signals determining cell fates
- Explains how up-to-date results of life technology and information are being applied in glycobiology research of cancers
- Inspires the application of knowledge about signals generated via glycosylation for diagnosis and therapy of cancers
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About this book
This book is a collection of cutting-edge studies on the functions and mechanisms of glycosylation in cancers. Along with progress in genomics and proteomics, new findings in the significance of these complex carbohydrates, through the regulation of cell signals, have been elucidated in a wide variety of biological events. This volume provides a comprehensive summary of glycosignals and their involvement in cancer, covering numerous topics such as glycosylation machineries, regulation of phenotypes, cell signaling, immune regulation, complex carbohydrate organization, and clinical applications. The contents have been organized to promote ready understanding, covering basic to clinical research and studies on micromolecules, to animal/human cells and tissues. This book is an essential read for students and young researchers interested in cancers and carbohydrates. Specialists in glycobiology will also benefit from the new results and approaches detailed here, which provide insights into future directions of functional studies of sugar chains in both basic and applied research.
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Keywords
Table of contents (11 chapters)
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Changes of Glycosylation Machineries in Cancer Cells
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Regulation of Cancer Phenotypes by Carbohydrates
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Altered Cell Signaling in Cancer Cells
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Regulation of Immune Systems and Cancers by Carbohydrates
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Changes in the Organization of Complex Carbohydrates in Cancers
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Implication of Sugars in Cancer Diagnostics and Therapeutics
Editors and Affiliations
Bibliographic Information
Book Title: Glycosignals in Cancer: Mechanisms of Malignant Phenotypes
Editors: Koichi Furukawa, Minoru Fukuda
DOI: https://doi.org/10.1007/978-4-431-55939-9
Publisher: Springer Tokyo
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Japan 2016
Softcover ISBN: 978-4-431-56732-5Published: 31 March 2018
eBook ISBN: 978-4-431-55939-9Published: 26 January 2016
Edition Number: 1
Number of Pages: VIII, 219
Number of Illustrations: 24 b/w illustrations, 10 illustrations in colour
Topics: Biochemistry, general, Cancer Research, Cell Biology, Oncology