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RNA and Cancer

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  • © 2013

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Overview

Editors:
  1. Jane Y. Wu

    1. Dept. of Neurology, Robert H. Lurie Cancer Center Center for Genetic Medicine, Chicago, USA

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  • Review of the most current advances in the understanding of post-transcriptional gene regulation
  • Special focus on RNA processing and its role in cancer development and treatment
  • Written by internationally renowned experts in the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Cancer Treatment and Research (CTAR, volume 158)

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About this book

Accumulating evidence supports the role of defects in post-transcriptional gene regulation in the development of cancer. RNA and Cancer examines the recent advances in our understanding of post-transcriptional gene regulation, especially RNA processing and its role in cancer development and treatment. A particular focus is mRNA splicing, but other topics such as microRNAs, mRNA stability, the perinucleolar compartment, and oligonucleotide therapeutics are also covered in detail. All chapters have been written by internationally renowned experts. The book is intended for all with an interest in gene regulation and cancer biology, and especially for those not directly working on RNA biology, including clinicians and medical students. It is hoped that it will stimulate further innovative research collaborations between RNA biologists and cancer researchers to the benefit of patients.

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Coupling Between Transcription and Alternative Splicing

    • Ignacio E. Schor, Luciana I. Gómez Acuña, Alberto R. Kornblihtt
    Pages 1-24
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  3. Detection of Alternatively Spliced or Processed RNAs in Cancer Using Oligonucleotide Microarray

    • Marieta Gencheva, Lixin Yang, Gong-Biao Lin, Ren-Jang Lin
    Pages 25-40
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  4. Cancer-Associated Perturbations in Alternative Pre-messenger RNA Splicing

    • Lulzim Shkreta, Brendan Bell, Timothée Revil, Julian P. Venables, Panagiotis Prinos, Sherif Abou Elela et al.
    Pages 41-94
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  5. Alternative Splicing of Tumor Suppressors and Oncogenes

    • Claudia Ghigna, Silvano Riva, Giuseppe Biamonti
    Pages 95-117
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  6. MicroRNAs in Cancer

    • Jianzhong Jeff Xi
    Pages 119-137
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  7. The Perinucleolar Compartment: RNA Metabolism and Cancer

    • John T. Norton, Sui Huang
    Pages 139-152
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  8. Regulation of ARE-mRNA Stability by Cellular Signaling: Implications for Human Cancer

    • Christian Kroun Damgaard, Jens Lykke-Andersen
    Pages 153-180
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  9. Alternative Pre-mRNA Splicing, Cell Death, and Cancer

    • Kong Ruirui, Payal Ray, Mengxue Yang, Pushuai Wen, Li Zhu, Jianghong Liu et al.
    Pages 181-212
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  10. Oligonucleotide Therapeutics in Cancer

    • Jing Wan, John A. Bauman, Maria Anna Graziewicz, Peter Sazani, Ryszard Kole
    Pages 213-233
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  11. Clinical Perspective on Chemo-Resistance and the Role of RNA Processing

    • Nancy L. Krett, Shuo Ma, Steven T. Rosen
    Pages 235-245
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Editors and Affiliations

  • Dept. of Neurology, Robert H. Lurie Cancer Center Center for Genetic Medicine, Chicago, USA

    Jane Y. Wu

Bibliographic Information

  • Book Title: RNA and Cancer

  • Editors: Jane Y. Wu

  • Series Title: Cancer Treatment and Research

  • DOI: https://doi.org/10.1007/978-3-642-31659-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2013

  • Hardcover ISBN: 978-3-642-31658-6Published: 20 March 2013

  • Softcover ISBN: 978-3-642-44485-2Published: 12 April 2015

  • eBook ISBN: 978-3-642-31659-3Published: 12 March 2013

  • Series ISSN: 0927-3042

  • Series E-ISSN: 2509-8497

  • Edition Number: 1

  • Number of Pages: XIII, 245

  • Topics: Oncology, Cancer Research, Human Genetics, Medical Biochemistry

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