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Stem Cell and Tissue Engineering in Female Urinary Incontinence

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Female Genitourinary and Pelvic Floor Reconstruction

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Abstract

Stress urinary incontinence (SUI) is a common condition, which affects the quality of life of female patients. There is a need for effective and durable treatment options that confer minimal morbidity to the patients. The newest frontier of treatment for SUI includes regenerative medicine with the use of cell-based therapies to restore the native continence mechanism via regeneration of the urethral sphincter complex. Cell-based therapies have thus far proven to be a promising option with increasing experimental, both in animal and human studies, and clinical investigations. The most extensively studied cell type being autologous muscle-derived cells (AMDCs). The literature to date has revealed this to be safe for the treatment of SUI in women, with larger clinical trials currently underway. Continued investigation regarding the mechanisms, effectiveness, and durability of injected cells will be necessary in order to make this innovative therapy option commercially available for use in patients.

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Authors and Affiliations

  1. Department of Urology, Vanderbilt University Medical Center, Nashville, TN, USA

    Elisabeth M. Sebesta & Melissa R. Kaufman

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  1. Elisabeth M. Sebesta
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  2. Melissa R. Kaufman
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Correspondence to Melissa R. Kaufman .

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Editors and Affiliations

  1. University of Lisbon, Lisbon, Portugal

    Francisco E. Martins

  2. University of Oslo, Oslo, Norway

    Henriette Veiby Holm

  3. Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Jaspreet S. Sandhu

  4. Eastern Virginia Medical School, Norfolk, VA, USA

    Kurt A McCammon

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Sebesta, E.M., Kaufman, M.R. (2023). Stem Cell and Tissue Engineering in Female Urinary Incontinence. In: Martins, F.E., Holm, H.V., Sandhu, J.S., McCammon, K.A. (eds) Female Genitourinary and Pelvic Floor Reconstruction. Springer, Cham. https://doi.org/10.1007/978-3-031-19598-3_28

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