Abstract
Polyhydroxyalkanoates (PHAs) are homo- or heteropolyesters synthesized and intracellularly stored by numerous prokaryotes. They can be produced in large quantities from renewable resources by means of well known fermentation processes and the imposition of particular culture conditions, and a number of physical or chemical methods are known to extract them from the producing biomass. Production processes such as batch, semi-batch and continuous fermentation are all known to work. PHAs have properties similar to those of some polyolefins. This, combined with the fact that they are fully and rapidly biodegraded under the appropriate conditions, has generated a high interest in them as substitutes to petroleum-based polymers in many applications [1].
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References
Fuller, R. C., and R. W. Lenz. 1990. Natural History 5: 82–84.
Chowdhury, A. A. 1963. Archiv. Mikrobiol. 47: 167–200.
Lemoigne, M. 1927. Ann. Inst. Pasteur 41: 148–165.
Macrae, R. M., and J. F. Wilkinson. 1958. J. Gen. Microbiol. 19: 210–222.
Macrae, R. M., and J. F. Wilkinson. 1958. Proc. R. Phys. Soc. Edin. 27: 73–78.
Delafield, F. P., M. Doudoroff, N. J. Palleroni, C. J. Lusty, and R. Contopoulos. 1965. J. Bacteriol. 90: 1455–1466.
Doudoroff, M., and R. Y. Stanier. 1959. Nature 183: 1440–1442.
Stockdale, H., D. W. Ribbons, and E. A. Dawes. 1968. J. Bacteriol. 95: 1798–1803.
Schlegel, H. G., G. Gottschalk, and R. von Bartha. 1961. Nature 191: 463–465.
Schlegel, H. G. 1962. Arch. Mikrobiol. 42: 110–116.
Jensen, T. E., and L. M. Sicko. 1971. J. Bacteriol. 106: 683–686.
Dawes, E. A., and P. J. Senior. 1973. Adv. Microbiol. Physiol. 10: 135–266.
Lundgren, D. G., R. Alper, C. Schnaitman, and R. H. Marchessault. 1965. J. Bacteriol. 89: 245–251.
Alper, R., and D. G. Lundgren. 1963. Biopolymers 1: 545–556.
Schlegel, H. G., and G. Gottschalk. 1962. Angew. Chem. 74: 342–347.
Cornibert, J., and R. H. Marchessault. 1972. J. Mol. Biol. 71: 735–756.
Wilkinson, J. F., and A. L. S. Munro. 1967. In Powell, E. O., C. G. T. Evans, R. E. Strange, and D. W. Tempest (eds.), Microbial physiology and continuous culture, H.M.S.O. London, pp. 173–185.
Boatman, E. S. 1964. J. Cell Biol. 20: 297–311.
Ellar, D., D. G. Lundgren, K. Okamura, and R. H. Marchessault. 1968. J. Mol. Biol. 35: 489–502.
Griebel, R., Z. Smith, and J. M. Merrick. 1968. Biochem. 7: 3676–3681.
Lundgren, D. G., R. M. Pfister, and J. M. Merrick. 1964. J. Gen. Microbiol. 34: 441–446.
Merrick, J. M., and M. Doudoroff. 1961. Nature 189: 890–892.
Merrick, J. M., D. G. Lundgren, and R. M. Pfister. 1965. J. Bacteriol. 89: 234–239.
Law, J. H., and R. A. Slepecky. 1961. J. Bacteriol. 82: 33–36.
Norris, K. P., and J. E. S. Greenstreet. 1958. J. Gen. Microbiol. 19: 566–580.
Williamson, D. H., and J. F. Wilkinson. 1958. J. Gen. Microbiol. 19: 198–209.
Emeruwa, A. C., and R. Z. Hawirko. 1973. J. Bacteriol. 116: 989–993.
Kominek, L. A., and H. O. Halvorson. 1965. J. Bacteriol. 90: 1251–1259.
Oeding, V., and H. G. Schlegel. 1973. Biochem. J. 134: 239–248.
Ritchie, G. A. F., and E. A. Dawes. 1969. Biochem. J. 112: 803–805.
Senior, P. J., G. A. Beech, G. A. F. Ritchie, and E. A. Dawes. 1972. Biochem. J. 128: 1193–1201.
Senior, P. J., and E. A. Dawes. 1971. Biochem. J. 125: 55–66.
Slepecky, R. A., and J. H. Law. 1961. J. Bacteriol. 82: 37–42.
Schuster, E., and H. G. Schlegel. 1967. Arch. Mikrobiol. 58: 380–409.
Senior, P. J., and E. A. Dawes. 1973. Biochem. J. 134: 225–238.
Griebel, R. J., and J. M. Merrick. 1971. J. Bacteriol. 108: 782–789
Ritchie, G. A. F., P. J. Senior, and E. A. Dawes. 1971. Biochem. J. 121: 309–316.
Gavard, R., A. Dahinger, B. Hauttecoeur, and C. Reynaud. 1966. C. R. Acad. Sci. Paris 263: 1273–1275.
Lusty, C. J., and M. Doudoroff. 1966. Biochem. 56: 960–96.
Merrick, J. M., and M. Doudoroff. 1964. J. Bacteriol. 88: 60–71.
Merrick, J. M., and C. I. Yu. 1966. Biochem. 5: 3563–3568.
Sierra, G., and N. E. Gibbons. 1962. Can. J. Microbiol. 8: 249–253.
Baptist, J. N. 1962. U.S. patent No. 3 036 959.
Baptist, J. N. 1962. U.S. patent No. 3 044 942.
Baptist, J. N. 1965. U.S. patent No. 3 182 036.
Baptist, J. N. 1963. U.S. patent No. 3 107 172.
W. R. Grace & Co. 1963. British patent specification No. 1 034 123.
Anonymous. 1995. Organization of Petroleum Exporting Countries. Britannica Online, version 1. 2. Britannica Advanced Publishing, Inc. ( World Wide Web information service. )
Anonymous. 1997. OPEC Annual Report 1996. OPECNA Information Department, Vienna, Austria.
Senior, P. G. 1984. In Dean, A. C. R., D. C. Ellwood, and C. G. T. Evans (eds.), Continuous culture, vol. 8, Ellis Horwood, Chichester, England, pp. 266–271.
King, P. 1982. J. Chem. Technol. Biotechnol. 32: 2–8.
Howells, E. R. 1982. Chem. Ind. 8: 508–511.
Fukada, E., and Ando, Y. 1988. Biorheology 25 (1–2): 297–302.
Wallen, L. L., and E. N. Davis. 1972. Environ. Sci. Technol. 6: 161–164.
Wallen, L. L., and W. K. Rohwedder. 1974. Environ. Sci. Technol. 8: 576–579.
De Smet, M. J., G. Eggink, B. Witholt, J. Kingma, and H. Wynberg. 1983. J. Bacteriol. 154: 870–878.
Findlay, R. H., and D. C. White. 1983. Appl. Environ. Microbiol. 45: 71–78.
Odham, G., A. Tunlid, G. Westerdahl, and P. Mrdén. 1986. Appl. Environ. Microbiol. 52:905–910.
Hughes, L., and K. R. Richardson. 1981. European patent No. 46 344.
Powell, K. A., B. A. Collinson, and K. R. Richardson. 1980. European patent No. 15 669.
Richardson, K. R. 1984. European patent No. 114 086.
Barham, P. J., and A. Selwood. 1982. European patent No. 58 480.
Holmes, P. A., and E. Jones. 1981. European patent No. 46 335.
Holmes, P. A., and G. B. Lim 1984. European patent No. 145 233.
Holmes, P. A., L. F. Wright, B. Alderson, and P. J. Senior. 1980. European patent No. 15 123.
Stageman, J. F. 1984. European patent No. 124 309.
Walker, J., J. R. Whitton, and B. Alderson. 1981. European patent No. 46 017.
Holmes, P. A., A. B. Newton, and F. M. Willmouth. 1981. European patent No. 52 460.
Holmes, P. A., L. F. Wright, and S. H. Collins 1982. European patent No. 69 497.
Luzier, W. D. 1992. Proc. Natl. Acad. Sci. USA 89: 839–842.
Naylor, L., Zeneca Bio Products. 1995. Personal communication, March 16.
Lenz, R. W. 1995. National Technical Information Service (NTIS) report # PB95199071 ( JTEC monograph ), U.S. Dept. of Commerce.
Lafferty, R. M., and G. Braunegg. 1988. Canadian patent No. 1 236 415.
Lafferty, R. M., and G. Braunegg. 1983. German patent No. 379 613.
Hrabak, O. 1992. FEMS Microbiol. Rev. 103: 251–256.
Poirier, Y., C. Nawrath, and C. Somerville. 1995. Bio/technol. 13: 142–150.
Naylor, L., Zeneca Bio Products. 1995. Personal communication, May 9.
Anderson, A. J., and E. A. Dawes. 1990. Microbiol. Rev. 54: 450–472.
Braunegg, G., and G. Lefebvre. 1993. Kern. Ind. 42: 313–322.
Lee, S.Y. 1996. Biotechnol. Bioeng. 49: 1–14.
Doi, Y. 1990. Microbial polyesters, VCH Publishers Inc., New York.
Steinbüchel, A., and H. E. Valentin. 1995. FEMS Microbiol. Lett. 128: 219–228.
Reusch, R. N. 1992. FEMS Microbiol. Rev. 103: 119–130.
Seebach, D., A. Brunner, H. M. Bürger, J. Schneider, and R. N. Reusch. 1994. Eur. J. Biochem. 224: 317–328.
Doi, Y., M. Kunioka, Y. Nakamura, and K. Soga. 1988. Macromolecules 21: 2722 2727.
Saito, Y., S. Nakamura, M. Hiramitsu, and Y. Doi. 1996. Polym. Int. 39: 169–174.
Doi, Y., A. Tarnaki, M. Kunioka, and K. Soga. 1987. Makromol. Chem., Rapid Commun. 8: 631–635.
Kunioka, M., Y. Nakamura, and Y. Doi. 1988. Polym. Commun. 29: 174–176.
Palleroni, N. J., and A. V. Palleroni. 1978. Int. J. Syst. Bacteriol. 28: 416–424.
Chen, G.-Q., K. H. König, and R. M. Lafferty. 1991. Antonie van Leeuwenhoek 60: 61–66.
Ramsay, B. A., K. Lomaliza, C. Chavarie, B. Dubé, P. Bataille, and J.A. Ramsay. 1990. Appl. Environm. Microbiol. 56: 2093–2098
Nakamura, S., Y. Doi, and M. Scandola. 1992. Macromolecules 25: 4237–4241.
Nakamura, K., Goto, Y., Yoshie, N., Inoue, Y., and R. Chujo. 1992. Int. J. Biol. Macromol. 14 (2): 117–118.
Steinbüchel, A., H. E. Valentin, and A. Schönebaum. 1994. J. Environ. Polym. Degrad. 2: 67–74.
Valentin, H. E., A. Schönebaum, and A. Steinbüchel. 1992. Appl. Microbiol. Biotechnol. 36: 507–514.
Nakamura, S., M. Kunioka, and Y. Doi. 1991. Macromol. Rep. A 28: 15–24.
Hiramitsu, M., and Y. Doi. 1993. Polymer 34: 4782–4786.
Hiramitsu, M., N. Koyama, and Y. Doi. 1993. Biotechnol. Lett. 15: 461–464.
Huisman, G. W., O. de Leeuw, G. Eggink, and B. Witholt. 1989. Appl. Environ. Microbiol. 55: 1949–1954.
Huijberts, G. N. M., G. Eggink, P. de Waard, G. W. Huisman, and B. Witholt. 1992. Appl. Environ. Microbiol. 58: 536–544.
Lee, E. Y., D. Jendrossek, A. Schirmer, C. Y. Choi, and A. Steinbüchel. 1995. Appl. Microbiol. Biotechnol. 42: 901–909.
Schirmer, A., D. Jendrossek, and H. G. Schlegel. 1993. Appl. Environ. Microbiol. 59: 1220–1227.
Abe, H., Doi, Y., Fukushima, T., and H. Eya. 1994. Int. J. Biol. Macromo1. 16 (3): 115–119.
de Koning, G. J. M., H. M. M. van Bilsen, P. J. Lemstra, W. Hasenberg, B. Witholt, H. Preusting, J. G. van der Galiën, A. Schirmer, and D. Jendrossek. 1993. Polymer 35: 2090–2097.
Kim, Y. B., R. W. Lenz, and R. C. Fuller. 1991. Macromolecules 24: 5256–5260.
Lenz, R. W., Y. B. Kim, and R. C. Fuller. 1992. FEMS Microbiol.Rev. 103:207–8. 107 Abe, C., Y. Taima, Y. Nakamura, and Y. Doi. 1990. Polym. Commun. 31: 404406.
Doi, Y., and C. Abe. 1990. Macromolecules 23: 3705–3707.
Kim, O., R. A. Gross., W. J. Hammar, and R. A. Newmark. 1996. Macromolecules 29: 4572–4581.
Kim, Y. B., R. W. Lenz, and R. C. Fuller. 1992. Macromolecules 25: 1852–1857.
Bear, M. M., M. A. Leboucherdurand, V. Langlois, R. W. Lenz, S. Goodwin, and P. Guerin. 1997. React. Funct. Polymers 34: 65–77.
Ulmer, H. W., R. A. Gross, M. Posada, P. Weisbach, R. C. Fuller, and R. W. Lenz. 1994. Macromolecules 27: 1675–1679.
Rodrigues, M. F. A., L. F. da Silva, J. G. C. Gomez, H. E. Valentin, and A. Steinbüchel. 1995. Appl. Microbiol. Biotechnol. 43: 880–886.
Fuchtenbusch, B., D. Fabritius, and A. Steinbüchel. 1996. FEMS Microbiol. Lett. 138: 153–160.
Mitomo, H., Takahashi, T., Ito, H., and T. Saito. 1999. Int. J. Biol. Macromol. 24 (4): 311–318.
Steinbüchel, A., E.-M. Debsi, R. H. Marchessault, and A. Timm. 1993. Appl. Microbiol. Biotechnol. 39: 443–449.
Kang, C. K., H. S. Lee, and J. H. Kim. 1993. Biotechnol. Lett. 15: 1017–1020.
Caballero, K.P., Karel, S.F., and R.A. Register. 1995. Int. J. Biol. Macromol. 17(2):86-92.
Takeda, M., Matsuoka, H., Ban, H., Ohashi, Y., Hikuma M., and J. Koizumi. 1995. Appl. Microbiol. Biotechnol. 44: 37–42.
Ballard, D. G. H., P. A. Holmes, and P. J. Senior. 1987. In Fontanille M., and A. Guyot (eds.), Recent advances in mechanistic and synthetic aspects of polymerization, vol. 215, Reidel (Kluywer) Publishing Co., Lancaster, U.K., pp. 293–314.
McCool, G. J., T. Fernandez, N. Li, and M. C. Cannon. 1996. FEMS Microbiol.Lett. 138: 41–48.
Dunlop, W. F., and A. W. Robards. 1973. J. Bacteriol. 114: 1271–1280.
Nuti, M. P., M. de Bertoldi, and A. A. Lepidi. 1972. Can. J. Microbiol. 18: 12571261.
Wang, W. S., and D. G. Lundgren. 1969. J. Bacteriol. 97: 947–950.
Barnard, G. N., and J. K. M. Sanders. 1989. J. Biol. Chem. 264: 3286–3291.
Barnard, G. N., and J. K. M. Sanders. 1988. FEBS Lett. 231: 16–18.
Hahn, S. K., Y. K. Chang, and S. Y. Lee. 1995. Appl. Environ. Microbiol. 61: 3439.
Mas, J., C. Pedrós-Alió, and R. Guerrero. 1985. J. Bacteriol. 164: 749–756
De Koning, G. J. M., and P. J. Lemstra. 1992. Polym. Commun. 33: 3292–3294.
Lauzier, C. A., and R. H. Marchessault. 1994. Symposium on Physiology, Kinetics, Production and Use of Biopolymers, Seggau, Austria. Proceedings, 5969.
Haywood, G. W., A. J. Anderson, and E. A. Dawes. 1989. FEMS Microbiol. Lett. 57: 1–6.
Stuart, E. S., L. J. R. Foster, R. W. Lenz, and R. C. Fuller. 1996. Int. J. Biol. Macromol. 19: 171–176.
Pranamuda, H., Y. Tokiwa, and H. Tanaka. 1995. Appl. Environ. Microbiol. 61: 1828–1832.
Foster, L. J. R., E. S. Stuart, A. Tehrani, R. W. Lenz, and R. C. Fuller. 1996. Int. J. Biol. Macromol. 19: 177–183.
Byrom, D. 1987. Tibtech 5: 246–250.
Repaske, R., and C. Repaske. 1976. Appl. Environ. Microbiol. 32: 585–591.
Henderson, R. A., and C. W. Jones. 1997. Arch. Microbiol. 168: 486–492.
Shi, H. D., M. Shiraishi, and K. Shimizu. 1997. J. Ferm. Bioeng. 84: 579–587.
Lee, I. Y., M. K. Kim, Y. H. Park, and S.Y.Lee. 1996. Biotechnol. Bioeng. 52: 707–712.
Doi, Y., A. Tamaki, M. Kunioka, and K. Soga. 1988. Appl. Microbiol. Biotechnol. 28: 330–334.
Doi, Y., M. Kunioka, Y. Nakamura, and K. Soga. 1987. Macromolecules 20: 2988 2991.
Doi, Y., A. Tamaki, M. Kunioka, and K. Soga. 1987. J. Chem. Soc., Chem. Commun. 1987: 1635–1636.
Kunioka, M., Y. Kawagushi, and Y. Doi. 1989. Appl. Microbiol. Biotechnol. 30: 569–573.
Valentin H. E., G. Zwingmann, A. Schönebaum, and A. Steinbüchel. 1995. Eur. J. Biochem. 227: 43–60.
Valentin, H. E., and D. Dennis. 1996. Appl. Environm. Microbiol. 62: 372–379.
Haywood, G. W., A. J. Anderson, L. Chu, and E. A. Dawes. 1988. FEMS Microbiol. Lett. 52: 91–96.
Doi, Y., Y. Kawaguchi, N. Koyama, S. Nakamura, M. Hiramitsu, Y. Yoshida, and H. Kimura. 1992. FEMS Microbiol. Rev. 103: 103–108.
Sim, S. J., K. D. Snell, S. A. Hogan, J. Stubbe, C. K. Rha, and A. J. Sinskey. 1997. Nature Biotechnol. 15: 63–67.
Wodzinska, J., K. D. Snell, A. Rhomberg, A. J. Sinskey, K. Biemann, and J. Stubbe. 1996. J. American Chem. Soc. 118: 6319–6320.
Steinbüchel, A., E. Hustede, M. Liebergesell, U. Pieper, A. Timm, and H. Valentin. 1992. FEMS Microbiol. Rev. 103: 217–230.
Peoples, O. P., and A. J. Sinskey. 1989. J. Biol. Chem. 264: 15293–15297.
Peoples, O. P., and A. J. Sinskey. 1989. J. Biol. Chem. 264: 15298–15303.
Schubert, P., A. Steinbüchel, and H. G. Schlegel. 1988. J. Bacteriol. 170: 58375847.
Slater, S. C., W. H. Voige, and D. E. Dennis. 1988. J. Bacteriol. 170: 4431–4436.
Schubert, P., N. Krüger, and A. Steinbüchel. 1991. J. Bacteriol. 173: 168–175.
Genser, K. F., G. Renner, and H. Schwab. 1998. J. Biotechnol. 64: 125–135.
Doi, Y., A. Segawa, Y. Kawaguchi, and M. Kunioka. 1990. FEMS Microbiol. Lett. 67: 165–170.
McInerney, M. J., D. A. Amos, K. S. Kealy, and J. A. Palmer. 1992. FEMS Microbiol. Rev. 103: 195–206.
Urmeneta, J., J. Mas-Castellà, and R. Guerrero. 1995. Appl. Environ. Microbiol. 61: 2046–2048.
Jackson, F.A., and E. A. Dawes. 1976. J. Gen. Microbiol. 97: 303–312.
Ward, A. C., B. I. Rowley, and E. A. Dawes. 1977. J. Gen. Microbiol. 102: 61–68.
Morinaga, Y., S. Yamanaka, A. Ishizaki, and Y. Hirose. 1978. Agric. Biol. Chem. 42: 439–444.
Sonnleitner, B., E. Heinzle, G. Braunegg, and R. M. Lafferty. 1979. Eur. J. Appl. Microbiol. Biotechnol. 7: 1–10.
Steinbüchel, A., and H. G. Schlegel. 1989. Appl. Microbiol. Biotechnol. 31: 168175.
Lefebvre, G., M. Rocher, and G. Braunegg. 1997. Appl. Environm. Microbiol. 63: 827–833.
Braunegg, G., and B. Bogensberger. 1985. Acta Biotechnol. 4: 339–345.
Manchak, J., and W. J. Page. 1994. Microbiology 140: 953–963.
Briese, B. H., B. Schmidt, and D. Jendrossek. 1994. J. Environ. Polym. Degrad. 2: 75–87.
Saito, T., A. Iwata, and T. Watanabe. 1993. J. Environ. Polym. Degrad. 1: 99–105.
Saito, T., K. Suzuki, J. Yamamoto, T. Fukui, K. Miwa, K. Tornita, S. Nakanishi, S. Odani, J.-I. Suzuki, and K. Ishikawa. 1989. Appl. Environ. Microbiol. 171: 184189.
Tanio, T., T. Fukui, Y. Shirakura, T. Saito, K. Tornita, T. Kaiho, and S. Masamune. 1982. Eur. J. Biochem. 124: 71–77.
Kita, K., K. Ishimaru, M. Teraoka, H. Yanase, and N. Kato. 1995. Appl. Environ. Microbiol. 61: 1727–1730.
Kita, K., S. Mashiba, M. Nagita, K. Ishimaru, K. Okamoto, H. Yanase, and N. Kato. 1997. Biochim. Biophys. Acta - Gene Structure and Expression. 1352: 113122.
Jendrossek, D., I. Knoke, R. B. Habibian, A. Steinbüchel, and H. G. Schlegel. 1993. J. Environ. Polym. Degrad. 1: 53–63.
Jendrossek, D., A. Friese, A. Behrends, M. Andermann, H. D. Kratzin, T. Stanislawski, and H. G. Schlegel. 1995. J. Bacteriol. 177: 596–607.
Müller, B., and D. Jendrossek. 1993. Appl. Microbiol. Biotechnol. 38: 487–492.
Schirmer, A., and D. Jendrossek. 1994. J. Bacteriol. 176: 7065–7073.
Ramsay, B. A., I. Saracovan, J. A. Ramsay, and R. H. Marchessault. 1994. J. Environ. Polym. Degrad. 2: 1–7.
Ostle, A., and J. G. Holt. 1982. Appl. Environ. Microbiol. 44: 238–241.
Braunegg, G., B. Sonnleitner, and R. M. Lafferty. 1978. Eur. J. Appl. Microbiol. Biotechnol. 6: 29–37.
Riis, V., and W. Mai. 1988. J. Chromatogr. 445: 285–289.
Morikawa, H., and R. H. Marchessault. 1981. Can. J. Chem. 59: 2306–2313.
Doi, Y., M. Kunioka, Y. Nakamura, and K. Soga. 1986. Macromolecules 19: 1274 1276.
Doi, Y., M. Kunioka, Y. Nakamura, and K. Soga. 1986. Macromolecules 19: 2860 2864.
Ratner, R.-R., R. M. Lafferty, and H.-J. Knackmuss. 1975. Eur. J. Appl. Microbiol. 1: 233–237.
Braunegg, G., G. Lefebvre, G. Renner, A. Zeiser, G. Haage, and K. LoidlLanthaler. 1995. Can J. Microbiol 41: 239–248.
Degelau, A., T. Scheper, J. E. Bailey, and C. Guske. 1995. Appl. Microbiol. Biotechnol. 42: 653–657.
Jacob, G.S., Garbow, J.R., and J. Schaefer. 1986. J. Biol. Chem. 261(36): 1678516787.
Cook, P. D.,Gao, Y., Smith, R., Toube, T. P., and J.H.P. Utley. 1995J. Mater. Chem. 5(3): 413–415.
Brandi, H., R. A. Gross, R. W. Lenz, and R. C. Fuller. 1988. Appl. Environ. Microbiol. 54: 1977–1982.
Berger, E., B. A. Ramsay, J. A. Ramsay, C. Chavarie, and G. Braunegg 1989. Biotechnol. Tech. 3:227–232.
Ramsay, J. A., E. Berger, B. A. Ramsay, and C. Chavarie. 1990. Biotechnol. Tech. 4: 221–226.
Hahn, S. K., Y. K. Chang, B. S. Kim, and H. N. Chang. 1994. Biotechnol. Bioeng. 44: 256–261.
Page, W. J., and A. Cornish. 1993. Appl. Environ. Microbiol. 59: 4236–4244.
Marchessault, R. I1., T. L. Bluhm, Y. Deslandes, G. K. Hamer, W. J. Orts, P. R. Sundarajan, M. G. Taylor, S. Bloembergen, and D. A. Holden. 1988. Makromol. Chem., Macromol. Symp. 19: 235–254.
Holmes, P. A. 1985. Phys. Technol. 16: 32–36.
Bluhm, T. L., G. K. Hamer, R. H. Marchessault, C. A. Fyfe, and R. P. Veregin. 1986. Macromolecules 19: 2871–2876.
Song, J.J., Yoon, S.C., Yu, S.M., and R.W.’Lenz. 1998. Int. J. Biol. Macromol. 23 (3): 165–173.
Scandola, M., Ceccorulli, G., and Doi Y. 1990. Int.J. Biol. Macromol. 12: 112117.
Terada, M., and R.H. Marchessault. 1999. Int. J. Biol. Macromol. 25(1–3): 207215.
Chen, G.-Q., and W. J. Page. 1994. Biotechnol. Lett. 16: 155–160.
Anderson, A. J., D. R. Williams, B. Taidi, E. A. Dawes, and D. F. Ewing. 1992. FEMS Microbiol. Rev. 103: 93–102.
Taidi, B., A. J. Anderson, E. A. Dawes, and D. Byrom. 1994. Appl. Microbiol. Biotechnol. 40: 786–790.
Koyama, N., and Y. Doi. 1995. Biotechnol. Lett. 17: 281–284.
Asenjo, J. A., A. S. Schmidt, P. R. Andersen, and B. A. Andrews. 1995. Biotechnol. Bioeng. 46: 497–502.
Kawaguchi, Y., and Y. Doi. 1992. Macromolecules 25: 2324–2329.
Suzuki, T., H. Deguchi, T. Yamane, S. Shimizu, and K. Gekko. 1988. Appl. Microbiol. Biotechnol. 27: 487–491.
Kang, C.-K., S. Kusaka, and Y. Doi. 1995. Biotechnol. Lett. 17: 583–588.
Doi, Y., Y. Kanesawa, M. Kunioka, and T. Saito. 1990. Macromolecules 23: 26–31.
Nishida, H., and Y. Tokiwa. 1993. J. Environ. Polym. Degrad. 1: 65–80.
Day, M., K. Shaw, and D. Cooney. 1994. J. Environ. Polym. Degrad. 2: 121–128.
Mergaert, J., C. Anderson, A. Wouters, and J. Swings. 1994. J. Environ. Polym. Degrad. 2: 177–183.
Gilmore, D. F., S. Antoun, R. W. Lenz, and R. C. Fuller. 1993. J. Environ. Polym. Degrad. 1: 269–274.
Briese, B. H., D. Jendrossek, and H. G. Schlegel. 1994. FEMS Microbiol. Lett. 117: 107–112.
Mayer, J. M., D. L. Kaplan, R. E. Stote, K. L. Dixon, A. E. Shupe, A. L. Allen, and J. E. McCassie. 1996. ACS Symposium Series 627: 159–170.
Ramsay, B.A., Langlade, V., Carreau, P.J., and J.A. Ramsay. 1993. Appl. Environ. Microbiol. 59 (4): 1242–1246.
Imam, S.H., Gordon, S.H., Shogren, R.L., Tosteson. T.R., Govind, N.S., and R.V. Greene. 1999. Appl. Environ. Microbiol. 65 (2): 431–437.
Koller, I., and Owen, A. J. 1996. Polym. Int. 39 (3), 175–81.
Cyras, V., Fernandez, P., Galego; N., and A. Vazquez. 1999. Polym. Int. 48 (8): 705–712.
Dubini Paglia, E., Beltrame, P. L., Canette, M., Seves, A., Marcandalli, B., and E. Martuscelli. 1993. Polymer 34 (5): 996–1001.
Sadocco, P., Bulli, C., Elegir, G., Seves, A., and E. Martuscelli. 1993. Makromol. Chem. 194 (10): 2675–2686.
Gatenholm, P.; and A. Mathiasson. 1994. J. Appl. Polym. Sci., 51 (7): 1231–1237.
Brandi, H., Aeberli, B., Bachofen, R., Schwegler, I., Muller, H.M., Burger M.H., Hoffmann, T., Lengweiler, U.D., and D. Seebach. 1995. Can.J. Microbiol.41 Suppl 1: 180–186.
Yoshie, N., Azuma, Y., Sakurai, M., and Y. Inoue. 1995. J. Appl. Polym. Sci., 56 (1): 17–24.
Al-Salah, Hasan A. 1998. Polymer Bulletin 41: 593–600.
Byrom, D. 1992. FEMS Microbiol. Rev. 103: 247–250.
Lee, S. Y., and H. N. Chang. 1995. In Fiechter, A. (ed.), Advances in biochemical engineering/biotechnology, vol. 52, Springer-Verlag, Berlin, pp. 27–58.
Beaulieu, M., Y. Beaulieu, J. Mélinard, S. Pandian, and J. Goulet. 1995. Appl. Environ. Microbiol. 61: 165–169.
Seki, H., M. Karita, and A. Suzuki. 1993. J. Chem. Eng. Jap. 27: 423–425.
Lee, S. Y. 1996. Trends Biotechnol. 14: 431–438.
Kim, B. S., S. C. Lee, S. Y. Lee, H. N. Chang, Y. K. Chang, and S. I. Woo. 1994. Enzyme Microb. Technol. 16: 556–561.
Suzuki, T., T. Yamane, and S. Shimizu. 1986. Appl. Microbiol. Biotechnol. 23: 322–329.
Koyama, N., and Y. Doi. 1993. J. Environ. Polym. Degrad. 3: 235–240.
Aragao, G. M. F., N. D. Lindley, J. L. Uribelarrea, and A. Pareilleux. 1996. Biotechnol. Lett. 18: 937–942.
Bitar, A., and S. Underhill. 1990. Biotechnol. Lett. 12: 563–568.
Lee, I. Y., M. K. Kim, G. J. Kim, H. N. Chang, and Y. H. Park. 1995. Biotechnol. Lett. 17: 571–574.
Fukui, T., and Y. Doi. 1998. Appl. Microbiol. Biotechnol. 49 (3): 333–336.
Cho, G., Yoon, J., Oh, J. T., and W. Kim. 1997. Hwahak Konghak 35 (3): 412–418.
Tanaka, K., K. Katamune, and A. Ishizaki. 1993. Biotechnol. Lett. 15: 1217–1222.
Rusendi, D., and J. D. Sheppard. 1995. Bioresource Technol. 54: 191–196.
Ishizaki, A., and K. Tanaka. 1991. J. Ferment. Bioeng. 71: 254–257.
Tanaka, K., A. Ishizaki, T. Kanamaru, and T. Kawano. 1994. Biotechnol. Bioeng. 45: 268–275.
Sheppard, J. D., P. Marchessault, T. Whalen, and S. F. Barrington. 1994. J. Chem. Tech. Biotechnol. 59: 83–89.
Katoh, T., Yuguchi, D., Yoshii, H., Shi, H., and K. Shimizu. 1999. J. Biotechnol. 67 (2–3): 113–134.
Kim, B. S., S. Y. Lee, and H. N. Chang. 1992. Biotechnol. Lett. 14: 811–816.
Wang, F. L., and S. Y. Lee. 1997. Appl. Environm. Microbiol. 63: 4765–4769.
Yim, K. S., S. Y. Lee, and H. N. Chang. 1996. Biotechnol. Bioeng. 49: 495–503.
Taga, N., Tanaka, K., and A. Ishizaki. 1999. Biotechnol. Bioengng. 62: 546–553.
Ramsay, B. A., J. A. Ramsay, and D. G. Cooper. 1989. Appl. Microbiol. Microbiol. 55: 584–589.
Alderete, J. A., D. W. Karl, and C.-H. Park. 1993. Biotechnol. Prog. 9: 520–525.
Park, C.-H., and V. K. Damodaran. 1994. Biotechnol. Bioeng. 44: 1306–1314.
Ueda, S., S. Matsumoto, A. Takagi, and T. Yamane. 1992. Appl. Environ. Microbiol. 58: 3574–3579.
Yamane, T., X. F. Chen, and S. Ueda. 1996. FEMS Microbiol. Lett. 135: 207–211.
Bourque, D., B. Ouellette, G. André, and D. Groleau. 1992. Appl. Microbiol. Biotechnol. 37: 7–12.
Daniel, M., J. H. Choi, J. H. Kim, and J. M. Lebeault. 1992. Appl. Microbiol. Biotechnol. 37: 702–706.
Bertrand, J.-L., B. A. Ramsay, J. A. Ramsay, and C. Chavarie. 1990. Appl. Environ. Microbiol. 56: 3133–3138.
Ramsay, B. A., I. Saracovan, J A Ramsay, and R. H. Marchessault. 1991. Appl. Environ. Microbiol. 57: 625–629.
Huijberts, G. N. M., and G. Eggink. 1996. Appl. Microbiol. Biotechnol. 46: 233239.
Kellerhals, M.B., Kessler, B., and B Witholt. 1999. Biotechnol. Bioengng. 65: 306–315.
Kim, G. J., I. Y. Lee, S. C. Yoon, Y. C. Shin, and Y. H. Park. 1997. Enz. Microbial Technol. 20: 500–505.
Preusting, H., R. van Houten, A. Hoefs, E. K. van Langenberghe, O. Favre-Bulle, and B. Witholt. 1992. Biotechnol. Bioeng. 41: 550–556.
Page, W. J., and O. Knosp. 1989. Appl. Environ. Microbiol. 55: 1334–1339.
Page, W. J. 1992. Appl. Microbiol. Biotechnol. 38: 117–121.
Page, W. J. 1989. Appl. Microbiol. Biotechnol. 31: 329–333.
Page, W. J., J. Manchak, and B. Rudy. 1992. Appl. Environ. Microbiol. 58: 28662873
Rodriguez-Valera, F., Garcia Lillo, J. A., Anton, J., and I. Meseguer. 1991. NATO ASI Ser., Ser. A, 201(Gen. Appl. Aspects Halophilic Microorg. ): 373–380.
Lemos, P. C., Viana, C., Salgueiro, E. N., Ramos, A. M., Crespo, J.P.S.G., and M.A.M. Reis. 1998. Enzyme Microb. Technol. 22 (8): 662–671.
Slater, S.C., Voige, W.H., and D.E. Dennis. 1988. J Bacterio1. 170 (10): 4431–4436.
Schubert, P., Steinbüchel, A., and H.G. Schlegel. 1988. J. Bacteriol. 170 (12): 5837–5847.
Park, J. S., Huh, T. L., and Y.H. Lee. 1997. Enzyme Microb.Technol. 21: 85–90.
Jackson, J. K., and F. Srienc. 1999. J. Biotechnol. 68: 49–60.
Choi, J.I., Lee, S.Y., and K. Han. 1998. Appl. Environ. Microbiol. 64(12): 48974903.
Matsusaki, H., Manji, S., Taguchi, K., Kato, M., Fukui, T., and Y. Doi. 1998. J Bacteriol. 180 (24): 6459–6467.
Prieto, M.A., Kellerhals, M.B., Bozzato, G.B., Radnovic, D, Witholt, B., and B. Kessler. 1999. Appl. Environ. Microbiol. 65 (8): 3265–3271.
Dennis, D., McCoy, M., Stangl, A., Valentin, H. E., and Z. Wu. 1998. J. Biotechnol. 64 (2, 3): 177–186.
Kichise, T., Fukui, T., Yoshida, Y., and Doi, Y. 1999. Int. J. Biol. Macromol. 25 (1–3): 69–77.
Hall, B., Baldwin, J., Rhie, H.G., and D. Dennis. 1998. Can. J. Microbiol. 44 (7): 687–691.
Taguchi, K., Aoyagi, Y., Matsusaki, H., Fukui, T., and Y. Doi. 1999. FEMS Microbiol. Lett. 176: 183–190.
Gerngross, T. U., and D.P. Martin. 1995. Proc. Natl. Acad. Sci. U. S. A., 92(14): 6279–6283.
Lenz, R.W., Farcet, C., Dijkstra, P.J., Goodwin, S., and S. Zhang. 1999. Int. J. Biol. Macromol. 25: 55–60.
Poirier, Y., D. Dennis, K. Klomparens, C. Nawrath, and C. Somerville. 1992. FEMS Microbiol. Rev. 103: 237–246.
Nawrath, C., Y. Poirier, and C. Somerville. 1994. Proc. Natl. Acad. Sci. USA 91: 12760–12764.
Rinehart, J. A., M. W. Petersen, and M. E. John. 1996. Plant Physiol. 112: 1331 1341.
John, M. E., and G. Keller. 1996. Proc. Natl. Acad. Sci. USA 93: 12768–12773.
Skow, J. 1995. Time International 146: 64–66.
Walker, J., and J.R. Whitton. 1982. United States Patent ÚS4358583, 09–11–1982.
Findley, R.H.; White, D.C. 1989. J. Microbiol. Methods 6: 113–120
Im, K. B., and K.J. Kim. Korean Patent KR 9502866, 27-03–1995.
Ohleyer, Eric, 1993, PCT Int. Appl. WO 9311656 Al
Holmes P.A. and Jones E., 1982. EP0046335 1982–02–24
Senior P. J. et al., 1982, Extraction process, US4324907 1982–04–13
Brake L.D., 1993, Recovery of polyhydroxy acids, US5264614 1993–11–23
Lafferty, R.M., and Heinzle, E., 1977. Chem. Rundschau 30:14–16
Kurdikar, D.L., Strauser, F.E., Solodar, A.J., Paster, M.D. 1988. US patent WO9846783, 1998–10–22
Tamer I.M., Moo-Young, M., and Chisty,Y., 1998. Bioprocess Engineering Abstract 19 (6), 459–468
Hahn S.K., Chang, Y.K., and Lee, S.Y., 1995. Appl. Environ. Microbiol. 61 (1): 3439
Ling, Y., Wong, H. H., Thomas, C. J., Williams, D. R. G., Middelberg, A. P. J., 1997. Bioseparation 7 (1), 9–15
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Braunegg, G. (2002). Sustainable Poly(Hydroxyalkanoate) (PHA) Production. In: Scott, G. (eds) Degradable Polymers. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-1217-0_8
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