Overview
- Study of the effect of Type I IFNs on the immune system, from beneficial to detrimental
- Focuses on the ability of certain bacterial components to activate the IFN I signaling pathways
- Discusses how pathogen-associated molecular patterns (PAMPs) are detected by toll-like receptors (TLRs)
- Includes supplementary material: sn.pub/extras
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About this book
The type I interferon (IFN) signaling pathway is well recognized as a pathway activated by viral infections. It is activated by a variety of microbial pattern recognition receptors including the Toll-like receptors, NOD-like receptors and several cytosolic receptors. Activation of the type I IFN pathway leads to the production of both antiviral factors and products that influence immune cell function. More recently it has been shown that bacteria are also capable of activating this pathway.
Bacterial Activation of Type I Interferons reviews both the current understanding of how different bacterial species are able to activate this pathway as well as the influence type I IFNs have on the outcome to infection. Several different bacterial species are covered, spanning Gram positive and Gram negative, intracellular, extracellular, and different host infection sites. An introduction to the pathogenesis of each organism is provided, and the signaling molecules involved in the activation of the type I IFN pathway and the role it plays in animal infection models are also covered.
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Table of contents (10 chapters)
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Front Matter
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Back Matter
Editors and Affiliations
Bibliographic Information
Book Title: Bacterial Activation of Type I Interferons
Editors: Dane Parker
DOI: https://doi.org/10.1007/978-3-319-09498-4
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2014
Hardcover ISBN: 978-3-319-09497-7Published: 15 October 2014
Softcover ISBN: 978-3-319-38502-0Published: 27 September 2016
eBook ISBN: 978-3-319-09498-4Published: 06 October 2014
Edition Number: 1
Number of Pages: VII, 129
Number of Illustrations: 2 b/w illustrations, 10 illustrations in colour
Topics: Bacteriology, Immunology, Infectious Diseases