Overview
- Gives an updated overview on the possible reasons of failure of new and promising therapeutic opportunities
- Provides extensive discussions of issues including pharmacodynamic and pharmacokinetic mechanisms of resistance, alterations in the drug target, activation of prosurvival pathways, ineffective induction of cell death, and plasticity of microenvironment
- Covers the diverse perspectives of basic scientists, clinical pharmacologists and clinicians
Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 249)
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About this book
A major objective of this book is to reveal unprecedented opportunities to understand and overcome drug resistance through the clinical assessment of rational therapeutic drug combinations and the use of predictive and prognostic biomarkers to enable patient stratification and tailor treatments. It offers to the readers an updated overview on the possible reasons of failure of new and promising therapeutic opportunities.
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Keywords
Table of contents (15 chapters)
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Front Matter
Editors and Affiliations
Bibliographic Information
Book Title: Mechanisms of Drug Resistance in Cancer Therapy
Editors: Mario Mandalà, Emanuela Romano
Series Title: Handbook of Experimental Pharmacology
DOI: https://doi.org/10.1007/978-3-030-10507-5
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2018
Hardcover ISBN: 978-3-030-10506-8Published: 23 January 2019
eBook ISBN: 978-3-030-10507-5Published: 10 January 2019
Series ISSN: 0171-2004
Series E-ISSN: 1865-0325
Edition Number: 1
Number of Pages: VIII, 297
Number of Illustrations: 1 b/w illustrations, 31 illustrations in colour
Topics: Pharmacology/Toxicology, Cancer Research, Drug Resistance, Molecular Medicine