Overview
- Editors:
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Derek Roith
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National Institutes of Health, Bethesda, USA
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Mohan K. Raizada
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University of Florida, Gainesville, USA
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About this book
The study of the insulin-like growth factor (IGF) family has become an exciting area of investigation. Initially, this family consisted of ligands (insulin, IGF-I and IGF-m and receptors (the insulin receptor, the type I or IGF-I receptor and the type II or IGF-IYM-6-P receptor). Subsequently, it was discovered that six specific binding proteips (lGFBPs 1-6) playa major role in the actions of this growth factor family. In addition, there are now more potential receptors when one considers the possible roles of the insulin-receptor related receptor (IRR) and hybrid receptor dimers composed of insulin and IGF-I receptor (half-receptors). Another important aspect of this area of research is the realization that the IGFs are not only essential for normal growth and development but, in addition play an important role in the normal specialized function(s) of all tissues of the body, including the nervous system, skeleton, reproductive system, kidney, and the immune system, to name but a few. The development of recombi!tant human IGF-I for clinical testing has been a major breakthrough for investigators. Potential uses include wound healing, reversal of catabolic states, diabetes, bone remodeling, recovery from acute renal failure and many others. will determine both its use and its potential hazards.
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Open access
29 April 2020
Table of contents (38 chapters)
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- Martin L. Adamo, Stefan Neuenschwander, Derek LeRoith, Charles T. Roberts Jr.
Pages 1-11
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- Jennifer M. Pell, R. Stewart Gilmour
Pages 13-23
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- Lawrence J. Slieker, Gerald S. Brooke, Ronald E. Chance, Li Fan, James A. Hoffmann, Daniel C. Howey et al.
Pages 25-32
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- Margaret A. Cascieri, Marvin L. Bayne
Pages 33-40
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- Youngman Oh, Hermann L. Müller, Heping Zhang, Nicholas Ling, Ron G. Rosenfeld
Pages 41-54
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- Leon A. Bach, Susan Hsieh, Katsu-ichi Sakano, Hiroyuki Fujiwara, James F. Perdue, Matthew M. Rechler
Pages 55-61
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- J. S. Sussenbach, R. J. T. Rodenburg, W. Scheper, P. Holthuizen
Pages 63-71
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- Carolyn A. Bondy, Edward Chin, Jian Zhou
Pages 73-77
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- Haim Werner, Charles T. Roberts Jr., Derek LeRoith
Pages 91-103
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- Renato Baserga, Pierluigi Porcu, Michele Rubini, Christian Sell
Pages 105-112
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- Karen A. Seta, Kristina S. Kovacina, Richard A. Roth
Pages 113-124
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- Valerie M. Watt, Peter Shier, Joanne Chan, Bradley A. Petrisor, Swarna K. Mathi
Pages 125-132
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- Maria A. Soos, Barbara T. Navé, Kenneth Siddle
Pages 145-157
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- Steven A. Rosenzweig, Barry S. Oemar, Norman M. Law, Uma T. Shankavaram, Bradley S. Miller
Pages 159-168
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- Sonia M. Najjar, Neubert Philippe, Simeon I. Taylor, Domenico Accili
Pages 169-174
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- Wieland Kiess, Andreas Hoeflich, Yi Yang, Ulrike Kessler, Allan Flyvbjerg, Bruno Barenton
Pages 175-188
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Editors and Affiliations
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National Institutes of Health, Bethesda, USA
Derek Roith
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University of Florida, Gainesville, USA
Mohan K. Raizada