Abstract
The insulin receptor (IR) and type I IGF receptor (IGFR) are widely distributed in mammalian tissues, though varying in concentration between different cell types. The receptors show considerable similarity in primary sequence within a common disulphide linked (αβ)2 subunit structure. The insulin receptor-related receptor (IRR), a third member of this receptor family for which a ligand has yet to be identified, apparently has a much more restricted tissue distribution (Shier and Watt, 1992). The IR and IGFR mediate overlapping biological responses for which the intrinsic tyrosine-specific kinase activity of the receptors appears to be essential. These tyrosine kinases are highly homologous and differences in signalling capacities of the IR and IGFR in a given cell background have not been clearly defined.
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Soos, M.A., Navé, B.T., Siddle, K. (1994). Immunological Studies of Type I IGF Receptors and Insulin Receptors: Characterisation of Hybrid and Atypical Receptor Subtypes. In: Le Roith, D., Raizada, M.K. (eds) Current Directions in Insulin-Like Growth Factor Research. Advances in Experimental Medicine and Biology, vol 343. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2988-0_15
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DOI: https://doi.org/10.1007/978-1-4615-2988-0_15
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