Abstract
Much thinking about the roles of IGF-I and -II is shaped by observations in the rat or mouse, although it is not clear to what extent these laboratory rodents reflect IGF system function or regulation in other species. For example, IGF-II is usually regarded primarily as a fetal growth factor because its postnatal expression is highly restricted in the rodent. However, in the human and other species, IGF-II levels are equal to or greater than IGF-I in the circulation and in various tissues of adults (reviewed ref. 1). In addition, current concepts about the importance of growth hormone induced IGF-I production in peripheral tissues are based on rodent studies and, to our knowledge, have not been supported by human data. In order to investigate the extent to which local patterns of IGF system expression are similar in the rat and human, we have compared IGF-I, IGF-II and IGF-I receptor gene expression in the kidney and ovary2–5.
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References
W.H. Daughaday and P. Rotwein, Insulin-like growth factors I and II. Peptide messenger ribonucleic acid and gene structures, serum, and tissue concentration, Endocrine Reviews 10:68 (1989).
E. Chin, J. Zhou and C.A. Bondy, Anatomical relationships in the pattern of IGF-I, IGFBP-1 and IGF-I receptor gene expression in the rat kidney, Endocrinology 130:3237 (1992).
E. Chin and C.A. Bondy, IGF system gene expression in the human kidney, J. Clin. Endocrinol.Metab.l5:962 (1992).
J. Zhou, E. Chin and C.A. Bondy, Cellular pattern of IGF-I and IGF-I receptor gene expression in the developing and mature follicle, Endocrinol.129:3281 (1991).
J. Zhou and C.A. Bondy, Anatomy of the Human Ovarian IGF System, Biol. Reprod. 48:467 (1993).
E. Chin, J. Zhou and C.A. Bondy, Anatomical and developmental patterns of facilitative glucose transporter gene expression in the rat kidney, J. Clin Invest 91:810 (1993).
E. Chin and C.A. Bondy, Increased local IGF-I gene expression in protein-induced renal hypertrophy,Prog. 75th Annual Meeting of Endo. Soc. Abstract (1993).
J. Zhou and C.A. Bondy, The anatomy of the human testicular IGF system, Prog 75th Annual Meeting of Endo Soc. Abstract (1993).
E.R. Hernandez, C.T. Roberts, D. LeRoith and E.Y. Adashi, Rat ovarian IGF-I gene expression is granulosa cell-selective, Endocrinology 125:572 (1989).
J.E. Oliver, J.R. Aitman, J.F. Powell, C.A. Wilson and R.N. Clayton, IGF-I gene expression in the rat ovary is confined to the granulosa cells of developing follicles, Endocrinology 124:2671 (1989).
E.R. Hernandez, A. Hurwitz, A. Vera, A. Pellicer, E.Y. Adashi, D. LeRoith and C.T. Roberts,Expression of the genes encoding the IGFs and their receptors in the human ovary. J. Clin. Endocrinol. Metab. 74:419 (1992).
F. Geisthovel, I. Moretti-Rojas, R.H. Asch and F.J. Rojas, Expression of IGF-II but not IGF-I mRNA in human preovulatory granulosa cells, Human Reprod. 4:899 (1989).
A. El-Roeiy, X. Chen, VJ. Roberts and S.S.C. Yen, Localization of mRNAs encoding IGF-I, IGF-II and receptors of IGF-I, IGF-II and insulin in normal human ovaries, Prog. 74th Annual meeting ofEndo. Soc. 237 (1992).
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© 1994 Springer Science+Business Media New York
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Bondy, C.A., Chin, E., Zhou, J. (1994). Significant Species Differences in Local IGF-I and -II Gene Expression. In: Le Roith, D., Raizada, M.K. (eds) Current Directions in Insulin-Like Growth Factor Research. Advances in Experimental Medicine and Biology, vol 343. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2988-0_8
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DOI: https://doi.org/10.1007/978-1-4615-2988-0_8
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