Overview
- Editors:
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Joel F. Habener
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Laboratory of Molecular Endocrinology, Howard Hughes Medical Institute, Massachusetts General Hospital, Boston
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Mehboob A. Hussain
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Department of Medicine, Clinical and Molecular Endocrinology, New York University Medical Center, New York
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About this book
Diabetes mellitus is rapidly increasing in prevalence throughout both developed and developing countries. The social and economic burden of this disease is estimated to cost 14 billion dollars worldwide. In the USA alone, 15 million individuals are diabetic, nearly half of them unaware of their condition. Complications of diabetes mellitus are the leading causes for blindness, limb amputation and chronic renal failure and kidney transplantation in industrialized countries. Further, diabetes mellitus per se and the metabolic derangement associated with diabetes are important risk factors for cardiovascular disease. Diabetes, as defined by an elevated fasting blood glucose level is presently subdivided in etiologically distinct groups. The most prevalent being type 2 (adult onset) diabetes characterized by insulin resistance and failure of the ~-cell to supply insulin in amounts sufficient to meet the body's needs. Type 1 (juvenile) diabetes, most commonly with an onset during childhood and adolescence, is caused by an auto-immune destruction of the pancreatic ~-cells. The causations of both type 1 and type 2 diabetes involve a combination of complex genetic traits and environmental influences. A third category are the mature onset diabetes of the young (MODY). This comparatively small group of patients (-10% of diabetes) presents relative early in life «30 years of age) compared to the more common late onset type 2 diabetes.
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Article
07 September 2020
Article
Open access
07 September 2020
Table of contents (23 chapters)
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Front Matter
Pages i-xiii
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- Ole D. Madsen, Palle Serup, Jan Jensen, Helle V. Petersen, R. Scott Heller
Pages 1-17
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- R. Paul Robertson, Jamie Harmon, Yoshito Tananka, Giovanni Sacchi, Phuong Oanh T. Tran, Catherine Gleason et al.
Pages 47-66
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- Susumu Seino, Takashi Miki, Hideki Yano
Pages 91-107
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- George G. Holz, Colin A. Leech
Pages 109-141
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- Paolo Meda, Domenico Bosco
Pages 143-163
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- Raphael Scharfmann, Paul Czernichow
Pages 165-175
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- Thomas S. Maldonado, Christopher A. Crisera, Alan S. Kadison, Michael T. Longaker, George K. Gittes
Pages 177-195
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- Ulf Ahlgren, Helena Edlund
Pages 197-212
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- Jan Jensen, Luis Emilio Flores, R. Scott Heller, Palle Serup, Ole D. Madsen
Pages 213-227
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- Gérard Waeber, Christophe Bonny
Pages 229-238
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- Kevin Gerrish, Susan Samaras, Michelle A. Cissell, Christopher V.E. Wright, Roland Stein
Pages 275-287
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- Susan Bonner-Weir, Gordon C. Weir
Pages 289-297
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- Rohit N. Kulkarni, C. Ronald Kahn
Pages 299-323
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- Julie C. Evans, Timothy M. Frayling, Andrew T. Hattersley
Pages 325-336
Reviews
`A very interesting text for both research and clinical endocrinologists.'
Journal of Pediatric Endocrinology and Metabolism, 15:4 (2002)
Editors and Affiliations
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Laboratory of Molecular Endocrinology, Howard Hughes Medical Institute, Massachusetts General Hospital, Boston
Joel F. Habener
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Department of Medicine, Clinical and Molecular Endocrinology, New York University Medical Center, New York
Mehboob A. Hussain