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Role of Mesenchymal-Epithelial Interactions in Pancreas Development

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Molecular Basis of Pancreas Development and Function

Part of the book series: Endocrine Updates ((ENDO,volume 11))

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Abstract

Mesenchyme is traditionally defined as a network of loosely organized mesodermal cells derived from the embryonic primitive streak with the potential to differentiate and give rise to structures such as connective tissue, blood and blood vessels, lymphatics, cartilage, muscle, bone, and stromal tissues of all glands. More recently, the mesenchyme has been found to play an increasingly sophisticated role in organogenesis through its interactions with other germ layers, specifically the endoderm. Mesenchymal-epithelial interactions have been shown to be important in the development of many organs including kidney, intestine, mammary, chick feathers, and salivary gland (1-5). The prepancreatic endoderm, originating in the duodenal anlage, requires its surrounding mesenchyme in order to differentiate into mature pancreas with acinar, ductal, and endocrine components (6-10).

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Authors and Affiliations

  1. New York University Medical Center, New York, N.Y., 10016, USA

    Thomas S. Maldonado M.D., Christopher A. Crisera M.D., Alan S. Kadison M.D., Michael T. Longaker M.D. & George K. Gittes M.D.

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  1. Thomas S. Maldonado M.D.
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  2. Christopher A. Crisera M.D.
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  3. Alan S. Kadison M.D.
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  4. Michael T. Longaker M.D.
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  5. George K. Gittes M.D.
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Editors and Affiliations

  1. Laboratory of Molecular Endocrinology, Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA

    Joel F. Habener M.D.

  2. Department of Medicine, Clinical and Molecular Endocrinology, New York University Medical Center, New York, NY

    Mehboob A. Hussain M.D.

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Maldonado, T.S., Crisera, C.A., Kadison, A.S., Longaker, M.T., Gittes, G.K. (2001). Role of Mesenchymal-Epithelial Interactions in Pancreas Development. In: Habener, J.F., Hussain, M.A. (eds) Molecular Basis of Pancreas Development and Function. Endocrine Updates, vol 11. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1669-9_10

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  • DOI: https://doi.org/10.1007/978-1-4615-1669-9_10

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