Summary
In this initial study, it has been postulated that even the simple bronchial administration of isotonic glucose and insulin can maintain alveolar cell metabolism as measured by A.T.P. activity; further studies, using aerosolized glucose solutions, will test the validity of the hypothesis that alveolar metabolism can be maintained by the administration of substrate in aerosolized form by the alveolar route and will determine whether this form of substrate administration has clinical potential.
Résumé
Une première étude permet de penser que la simple administration endobronchique de glucose isotonique et d’Insuline peut maintenir le métabolisme cellulaire alvéolaire, tel que démontré par la mesure de l’activité A.T.P. Poursuivant ces travaux avec des solutions de glucose en aérosols, nous chercherons à vérifier l’hypothèse que le métabolisme cellulaire peut être maintenu de cette manière et explorerons le potentiel clinique d’une telle approche.
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References
Rhoades, R.A. Net uptake of glucose, glycerol and fatty acids by the isolated perfused rat lung. Am. J. Physiol.226: 144–149 (1974).
Kennedy, E.P. The metabolism and function of complex lipids. Harvey Lectures ser.57: 143–171 (1961-62).
Klaus, M., Reiss, O.K., Tooley, W.H., Piel, C., &Clements, J.A. Alveolar epithelial cell mitochondria as a source of surface-active lining material. Science137: 750–751 (1962).
Thomas, T. Jr. &Rhoades, R.A. Incorporation of palmitate-l-14C into lung tissue lecithin and alveolar lecithin. Am. J. Physiol.219: 1535–1538 (1970).
Moore, F.D., Lyons, J.H., Pierce, E.C., Morgan, A.P., Drinker, P.A., MacArthur, J.P., &Dammin, G.J. Post-traumatic pulmonary insufficiency. W.B. Saunders Co. (1969).
Csaky, T.Z. &Wilson, J.E. The fate of 3-O-14CH3-glucose in the rat. Biochim. Biophys. Acta22: 185–186 (1956).
Modry, D.L., Jirsch, D.W., Boehme, G., Fisk, R.L., &Couves, C.M. Perfusion of the isolated lung: The role of glucose and insulin in the perfusate. Can. J. Surg. (in press).
McArdle, A.H., Chiu, C.J., &Gurd, F.N. Intraluminal glucose: substrate for ischémic intestine. Arch Surg.105: 441–445 (1972).
Forte, J.J., Adams, P.H., &Davies, R.E. Acid secretion and phosphate metabolism in bullfrog gastric mucosa. Biochim. Biophys. Acta104: 28–38 (1965).
Crowell, J.W., Jones, C.E., &Smith, E.E. Effect of allopurinol on haemorrhagic shock. Am. J. Physiol.216: 744–748 (1969).
Loiselle, J.M. &Denstedt, O.F. Biochemical changes during acute physiological failure in the rat II. The behaviour of adenine and pyridine nucleotides of the liver during shock. Can. J. Biochem.42: 21–34 (1964).
McShaw, W.H., Potter, V.R., Goldman, A., Shipley, E.G., &Meyer, R.K. Biological energy transformations during shock as shown by blood chemistry. Am. J. Physiol.145: 93–106 (1945).
Dowd, J. &Jenkins, L.C. The lung in shock: a review. Canad. Anaesth. Soc. J.19: 309–318 (1972).
Henry, J.W., McArdle, A.H., Scott, H.J., &Gurd, F.N. A study of the acute and chronic respiratory pathophysiology of haemorrhagic shock. J. Thor, and Cardiovasc. Surg.54: 666–678 (1967).
Weber, K.C. &Visscher, M.B. Metabolism of the isolated canine lung. Am. J. Physiol.217: 1044–1052 (1969).
Rubenstein, A.H., Zwi, S., &Miller, K. Insulin and the lung. Diabetologia4: 236–238 (1968).
White, A., Handler, P., Smith, E.L. &Stetten DeWitt Jr. Carbohydrate metabolism: The phosphogluconate oxidative pathway. Principles of biochemistry (2nd ed.). New York. McGraw-Hill, pp. 411–413 (1959).
Deutrebande, L. Deposition of air-borne particles, Microaerosols p. 78, New York, (Academic Press) (1962).
Horovitz, J.H., Carrico, C.J., &Shires, T. Pulmonary responses to major injury. Arch. Surg.108: 349–355 (1974).
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Hewson, J.R., Holland, A.J.C. “A Spoonful of sugar” — Trans-alveolar nutrition. Canad. Anaesth. Soc. J. 22, 539–546 (1975). https://doi.org/10.1007/BF03013406
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DOI: https://doi.org/10.1007/BF03013406