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In an experimental myocardial infarction model, L-arginine pre-intervention may exert cardioprotective effects by regulating OTULIN levels and mitochondrial dynamics

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Cell Stress and Chaperones Aims and scope

Abstract

The experimental myocardial infarction (MI) model originating from isoproterenol (ISO) is frequently preferred in research due to its similarity to MI-induced damage in humans. Beneficial effects of L-arginine (L-Arg), a semi-essential amino acid, in cardiovascular diseases have been shown in many studies. This study was carried out to determine whether L-Arg pre-intervention has protective effects on heart tissue in the experimental MI model. The 28 rats used in the study were randomly divided into 4 equal groups: control, L-Arg, ISO, and L-Arg+ISO. Upon completion of all applications, cardiac markers in serum and biochemical, histopathological, and immunohistochemical examinations in cardiac tissues were performed. Cardiac markers, histopathological changes, oxidative stress, inflammation, and apoptosis were increased in the experimental MI model. In addition, administration of ISO deregulated OTULIN levels and mitochondrial dynamics in heart tissue. However, L-Arg pre-intervention showed a significant protective effect against changes in ISO-induced MI. L-Arg supplementation with cardioprotective effect may reduce the risks of possible pathophysiological processes in MI.

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Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Vocational Higher School of Healthcare Studies, Batman University, Batman, Turkey

    Sercan Kaya & Tuba Yalcın

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  1. Sercan Kaya
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  2. Tuba Yalcın
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Contributions

All authors contributed to the understanding and design of the study. The implementation of the experimental procedure, material preparation, laboratory studies, data collection, and analysis were carried out by Sercan Kaya and Tuba Yalçın. All authors have read and approved the final article.

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Correspondence to Sercan Kaya.

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This study has been approved by the decision of Fırat University Animal Experiments Local Ethics Committee with the number 9555 and dated 08.07.2022.

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The authors declare no competing interests.

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Kaya, S., Yalcın, T. In an experimental myocardial infarction model, L-arginine pre-intervention may exert cardioprotective effects by regulating OTULIN levels and mitochondrial dynamics. Cell Stress and Chaperones 28, 811–820 (2023). https://doi.org/10.1007/s12192-023-01373-6

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  • DOI: https://doi.org/10.1007/s12192-023-01373-6

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