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Polyartikuläre Verlaufsformen der juvenilen idiopathischen Arthritis

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Pädiatrische Rheumatologie

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Zusammenfassung

Bei der juvenilen idiopathischen Arthritis kann eine Polyarthritis, der Befall von zumindest 5 Gelenken, bereits initial bestehen oder sich im Verlauf aus einer Oligoarthritis oder anderen JIA-Kategorien entwickeln. Einerseits ist die Prognose bei einem polyartikulären Verlauf eher zweifelhaft und insbesondere bei der rheumafaktorpositiven Polyarthritis wird nur selten eine stabile medikamentenfreie Remission erreicht, anderseits stehen für die Polyarthritis die meisten geprüft wirksamen und zugelassen Medikamente zur Verfügung. Hier ist als konventionelles Basistherapeutikum insbesondere Methotrexat zu nennen und dann die Gruppe der Biologika und hier v. a. die Inhibitoren der Zytokine TNF-α und Interleukin-6. Diese Therapieoptionen ermöglichen moderne Therapiekonzepte nach dem Treat-To-Target-Prinzip und damit ein frühes Erreichen einer Remission und die Vermeidung von Krankheitsschäden bei nicht allen, doch bei der großen Mehrheit der Patienten.

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Authors and Affiliations

  1. Zentrum Allgemeine Pädiatrie und Neonatologie, Asklepios Klinik Sankt Augustin GmbH, Sankt Augustin, Deutschland

    Gerd Horneff

  2. Charité Universitätsmedizin Berlin und Deutsches Rheumaforschungszentrum Berlin, Berlin, Deutschland

    Kirsten Minden

  3. Klinik für Pädiatrische Rheumatologie und Immunologie, Universitätsklinikum Münster, Münster, Deutschland

    Dirk Föll

  4. Pädiatrie, Sekt. Rheumatologie, Sozialpädiatrisches Zentrum, Charité – Universitätsmedizin Berlin, Berlin, Deutschland

    Günther Dannecker

Authors
  1. Gerd Horneff
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  2. Kirsten Minden
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  3. Dirk Föll
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  4. Günther Dannecker
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Corresponding author

Correspondence to Gerd Horneff .

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Editors and Affiliations

  1. Universitätsklinikum Aachen Klinik für Kinder- und Jugendmedizin, Aachen, Germany

    Norbert Wagner

  2. 15306 Seelow, Germany

    Günther Dannecker

  3. Kinderklinik, Charité Universitätsmedizin Berlin, Berlin, Berlin, Germany

    Tilmann Kallinich

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Horneff, G., Minden, K., Föll, D., Dannecker, G. (2021). Polyartikuläre Verlaufsformen der juvenilen idiopathischen Arthritis. In: Wagner, N., Dannecker, G., Kallinich, T. (eds) Pädiatrische Rheumatologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-60411-3_28-1

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