Abstract
Cadmium is chemically related to zinc and found wherever zinc occurs in nature. Cadmium is emitted to air and water by mines, metal foundries, viz. brass and industries using Cadmium in alkaline accumulators, alloys, paints and plastics. Cadmium exposure results in increase of concentration of a protein, called metallothionein, which plays an important role in detoxification of heavy metals. In persons not exposed to high amounts of cadmium, the concentration of cadmium in blood, bound mainly to red blood cells, is very small, less than 1 µg/100 mL whole blood. Gontzea and Popescu1 revealed that rats reared on low protein (casein 8.8%) diet were more susceptible to the adverse effects (blood and liver enzyme parameters) of injected Cd, than control given a diet with 17.8% casein. The present study was conducted on rats maintained on normal (21% protein) and protein malnourished (8% protein) diets. Exposure to cadmium in growing rats induced structural anomalies in the erythrocytes and leukocytes. Microcytic hypochromic anemia with erythrocytopenia and leukocytopenia were evident. Protein malnutrition appears to enhance the vulnerability of the animals to these changes.
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Gontzea, I. & Popescu, F. The effect of body protein supply on resistance to cadmium. Brit. J. Ind. Med. 35, 154–160 1978.
Husain, S. S. Studies on hepato and renal toxicity of cadmium on normal and protein malnourished rats. J. Material Sci. Eng. 2, 129 (2013).
Husain, S. S. Behavioral toxicity of cadmium in normal and protein malnourished rats (Two-Generation Study). Biochem. Physiol. 3, 124 (2014).
Kocak, M. & Akcil, E. The effects of chronic cadmium toxicity on the hemostatic system, Pathophysiol. Haemost. Thromb. 6, 411–416 2006.
Wilson, R. H., Deeds, F. & Cox, A. J. Dietary cadmium and the development of Anaemia. J. Pharmacol. Exp. Ther. 71, 222–227 1941.
Friberg, L. Health hazards in the manufacture of alkaline accumulators with special reference to chronic cadmium poisoning; a clinical and experimental study. Acta Med. Scand. 138, 1–124 1950.
OGNJANOVIC, B. I. et al. Protective influence of Vitamin E on antioxidant defense system in the blood of rats treated with cadmium. Physiol. Res. 52, 563–570 (2003).
Kowalczyk, E. et al. effect of long-term cadmium intoxication on selected biochemical parameters in experimental animals. Pol. J. Environ. Stud. 11, 599–601 (2002).
Berlin, M. & Friberg, L. Bone marrow activity and erythrodestruction in chronic cadmium poisoning. Arch. Environ. Health 3, 176–179 1961.
Fox, M. R. S. & Fry, B. E. Cadmium toxicity decreased by dietary ascorbic acid supplements. Science 169, 989–990 1970.
Fox, M. R. S. et al. Effects of ascorbic acid on cadmium toxicity in the young coturnix. J. Nutr. 101, 1295–1298 1971.
Pond, W. G. & Walker, E. F. Jr. Cadmium induced anemia in growing rats, prevention by parenteral iron. Nutrition and Reproduction Int. 5, 356–370 1972.
Stowe, H. D., Wilson, M. & Goyer, R. A. Clinical and morphological effects of oral cadmium toxicity in rabbits. Arch. Pathol. 94, 389–405 1972.
Berlin, M. & Piscator, M. Blood volume in normal and cadmium poisoned rabbits. Arch. Environ. Health 2, 576–583 1961.
Axelsson, B. & Piscator, M. Renal damage after prolonged exposure to cadmium: an experimental study. Arch. Environ. Health 12, 360–373 (1966a).
Nordberg, G., Friberg, L. & Piscator, M. in Cadmium in the Environment, 2nd Edn (CRC Press, Cleveland, Ohio, 1971).
Fitzhugh, O. G. & Meiller, F. H. “Sub acute toxicity,” Appraisal of the Safety of Chemicals. JPET 72, 15 (1941).
Cousins, R. J., Barber, A. K. & Trout, J. R. Cadmium toxicity in growing swine. J. Nutr. 103, 964 (1972).
Freeland, J. H. & Cousins, R. J. Effect of dietary cadmium on anemia, iron absorption, and cadmium binding protein in the chick. Nutr. Rep. Int. 8, 337–347 1973.
Decker, L. E. et al. Chronic toxicity studies. I. Cadmium administered in drinking water to rats. AMA. Ind. Health 18, 228–231 1958.
Petering, H. G., Murthy, L. & Cerklewski, F. L. in Biochemical Effects of Environmental Pollutants (eds Lee, S.D. Ann.) 365 (Arbor Science, Ann. Arbor, MI. 1977).
Umoli, I. B., Maduagwu, E. N. & Amole, A. A. Fate of ingested linamarin in malnourished rats. Food Chem. 20, 1–9 1986.
Petering, H. G., Choudhary, H. & Stemmer, K. L. Some effects of oral ingestion of cadmium on zinc, copper, and iron metabolism. Environ. Health Persp. 28, 97–106 (1979).
Freeland, J. H. & Cousins, R. J. Effect of dietary cadmium on anemia, iron absorption, and cadmium binding protein in the chick. Nutr. Rep. Int. 8, 337–347 1973.
Prigge, E. Early signs of oral and inhalative cadmium uptake in rats. Arch. Tox. 40, 231–247 1978.
Washko, P. W. & Cousins, R. J. Role of Dietary Calcium and Calcium Binding Protein in Cadmium Toxicity in Rats. J. Nutr. 107, 920–928 1977.
Axelsson, B. & Piscator, M. Renal damage after prolonged exposure to cadmium: An experimental study. Arch. Environ. Health 12, 360–373 1966.
Horiguchi, H. et al. Hypoproduction of erythropoietin contributes to anaemia in chronic cadmium intoxication: clinical studies on itai-itai disease in Japan. Arch. Toxicol. 68, 632–636 1994.
Hoiguchi, H. et al. Long term cadmium exposure induces anaemia in rats through hypoinduction of erythropoietin in the kidney. Arch. Toxicol. 71, 11–19 1996.
Pindborg, E. V., Pindborg, J. J. & Plum, C. M. Studies on incisor pigmentation in relation to liver iron and blood picture in the white rat. Acta Pharmacology and Toxicology 2, 302 (1946).
Buckley, J. A. Heinz body hemolytic anemia in coho salmon (Oncorhynchus kisutch) exposed to chlorinated seawater. J. Fish. Res. Board Can. 34, 215–224 1977.
Gill, S. T. & Pant, J. C. Erythrocytic and leucocytic response to cadmium poisoning in fresh water fish Puntius conchonius. Environ. Res. 36, 327 (1985).
Benesch, R. E. & Benesch, R. Relation between erythrocyte integrity and sulfhydryl groups. Arch. Biochem. Biophys. 48, 38–42 1954.
Loeser, E. & Lorke, D. Semi chronic oral toxicity of cadmium. I. Studies on rats. Toxicology 7, 215–224 1977.
Loeser, E. & Lorke, D. Semi chronic oral toxicity of cadmium. II. Studies on dogs. Toxicology 7, 225–232 1977.
Itokawa, Y., Abe, T., Tabei, R. & Tanaka, S. Renal and skeletal lesions in experimental cadmium poisoning. Arch. Environ. Health 28, 149–154 1974.
Oshawa, M. & Kawai, M. Cytological shift in lymphocytes induced by cadmium in mice and rats. Environ. Res. 24, 192–200 1981.
WINTROBE, M. M. et al. in Clinical Hematology 8th Edn (Lee & Febiger, Philadelphia, 1981).
Hesser, E. F. Methods for routine fish haematology. Prog. Fish Cult. 22, 104–171 1960.
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Husain, S.S. Hemotoxic effects of cadmium in normal and protein malnourished rats. Toxicol. Environ. Health Sci. 7, 129–135 (2015). https://doi.org/10.1007/s13530-015-0231-3
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DOI: https://doi.org/10.1007/s13530-015-0231-3