Abstract
We developed a stable hydrophilic biocompatible hydrogel-forming coating for polypropylene (PP)-based disposal medical applications. Although PP has a variety of advantages, including good stability and inertness in medical applications, tissue damage and insertion resistance are observed upon insertion of PP-based devices into the human body due to the high hydrophobicity of the PP surface. These issues limit the utility of PP in medical applications. To address these problems, we sought to develop a stable hydrophilic and biocompatible hydrogel-forming layer using polyvinyl pyrrolidone (PVP) combined with a crosslinked polyethyleneglycolacrylate (PEGDA) matrix. Systematic studies of the blended hydrogel-forming PVP:PEGDA were conducted using a variety of blending ratios between the two polymers. The hydrophilicity and water-affinity of the hydrogel-forming layer improved significantly as the PEGDA-to-PVP blending ratio increased. Importantly, the tensile strain at the break point increased by a factor of more than 7, and the strength of adhesion to the PP surface for the 1:1 PVP:PEGDA (PVP(1):PEGDA(1)) blend ratio was 54 times that of the PVP film, determined using tensile strain–stress and peel tests. The water stability of the PVP(1):PEGDA(1) improved significantly. This approach is potentially useful as a biocompatible hydrophilic polymer coating in a variety of low-priced consumable PP commercial medical applications.
Article PDF
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
References
G. H. Wheatley III, R. McNutt, and E. B. Diethrich, Ann. Thorac. Surg., 83, 272 (2007).
L. A. Eisen, M. Narasimhan, J. S. Berger, P. H. Mayo, M. J. Rosen, and R. F. Schneider, J. Intensive Care Med., 21, 40 (2006).
A. R. Forauer and C. Theoharis, J. Vasc. Interv. Radiol., 14, 1163 (2003).
M. Usui and T. Tanaka, J. Cataract. Refract. Surg., 41, 1745 (2015).
G. Kleinmann, A. L. Marcovich, D. J. Apple, and N. Mamalis, Br. J. Ophthalmol., 89, 1474 (2005).
G. R. Barbeau, Catheter. Cardiovasc. Interv., 59, 442 (2003).
S. Saito, S. Tanaka, Y. Hiroe, Y. Miyashita, S. Takahashi, S. Satake, and K. Tanaka, Catheter. Cardiovasc. Interv., 59, 305 (2003).
Y. Ikada and H. Tsuji, Macromol. Rapid Commun., 21, 117 (2000).
J. Jagur-Grodzinski, Polym. Adv. Technol., 17, 395 (2006).
N. Karode, L. Fitzhenry, S. Matthews, P. Walsh, and A. Coffey, Mater. Sci. Forum, 883, 75 (2017).
L. S. Nair and C. T. Laurencin, Prog. Polym. Sci., 32, 762 (2007).
T. E. Lipatova and Y. S. Lipatov, Macromol. Symp., 152, 139 (2000).
D. B. Hazer, M. Mut, N. Dincer, Z. Saribas, B. Hazer, and T. Ozgen, Childs Nerv. Syst., 28, 839 (2012).
S. H. Ajili, N. G. Ebrahimi, and M. T. Khorasani, J. Appl. Polym. Sci., 89, 2496 (2003).
S. Saxena, A. R. Ray, A. Kapil, G. P. Djavid, D. Letourneur, B. Gupta, and A. M. Pelle, Macromol. Biosci., 11, 373 (2011).
A. S. Hoffman, Adv. Drug Deliv. Rev., 64, 18 (2012).
C. Lin and A. T. Metters, Adv. Drug Deliv. Rev., 58, 1379 (2006).
J. J. Moon, M. S. Hahn, I. Kim, B. A. Nsiah, and J. L. west, Tissue Eng. Part A, 15, 579 (2009)
I. Gibas, and H. Janik, Chem. Chem. Techonol., 4, 297 (2010).
S. F. Dana, D. Nguyen, J. S. Kochhar, X. Liu, and L. Kang, Soft Matter, 9, 6270 (2013).
M. T. Razzak, D. Darwis, Zainuddin, and Sukirno, Radiat. Phys. Chem., 62, 107 (2001).
R. K. Mishra, M. Datt, and A. K. Banthia, PharmSciTech, 9, 395 (2008).
Y. Kaneda, Y. Tsutsumi, Y. Yoshioka, H. Kamada, Y. Yamamoto, H. Kodaira, S. Tsunoda, T. Okamoto, Y. Mukai, H. Shibata, S. Nakagawa, and T. Mayumi, Biomaterials, 25, 3259 (2004).
R. Morent, N. D. Geyter, C. Leys, L. Cengembre, and E. Payen, Surf. Interface Anal., 40, 597 (2008).
Y. Yagci, M. Sangermano and G. Rizza, Chem. Commun., 24, 2771 (2008).
W. A. Braunecker, and K. Matyjaszewski, Prog. Polym. Sci., 32, 93 (2007).
Y. Li, R. Zhang, H. Chen, J. Zhang, R. Suzuki, T. Ohdaira, M. M. Feldstein, and Y. C. Jean, Biomacromolecules, 4, 1858 (2003)
A. L. Gershon, L. S. Gyger Jr., H. A. Bruck, and S. K. Gupta, Exp. Mech., 48, 789 (2008).
H. S. Han, H. R. Kang, S. W. Kim, and H. T. Kim, J. Power Sources, 112, 461 (2002).
T. Qian, J. H. Kim, S. Kumar, and P. L. Taylor, Phys. Rev. E, 61, 4007 (2000).
X. Liu, Y. Won and P. X. Ma, J. Biomed. Mater. Res., 74A, 84 (2005).
M. Bae, R. Divan, K. J. Suthar, D. C. Mancini, and R. A. Gemeinhart, J. Vac. Sci. Technol., 28, 24 (2010).
S. T. Knauert, J. F. Douglas, and F. W. Starr, J. Polym. Sci., Part B: Polym. Phys., 45, 1882 (2007).
N. Roy, N. Saha, T. Kitano, and P. Saha, Soft Matter, 8, 130 (2010).
A. M. Wokovich, S. Prodduturi, W. H. Doub, A. S. Hussain, and L. F. Bruhse, Eur. J. Pharm. Biopharm., 64, 1 (2006).
N. Bait, B. Grassl, C. Derail, and A. Benaboura, Soft Matter., 7, 2025 (2011).
J. Zhang, Z. Liu, H. Du, Y. Zeng, L. Xing, and A. Dong, Pharm. Res., 26, 1398 (2009).
J. C. Seo, W. B. Jang, S. K. Lee, and H. S. Han, Polym. Degrad. Stab., 93, 298 (2008).
Author information
Authors and Affiliations
Corresponding authors
Additional information
Acknowledgments: This research was financially supported by the Ministry of Trade, Industry & Energy (MOTIE), Korea Institute for Advancement of Technology (KIAT) through the Encouragement Program for The Industries of Economic Cooperation Region (R0004715).
Rights and permissions
About this article
Cite this article
Jang, H., Choi, H., Jeong, H. et al. Thermally Crosslinked Biocompatible Hydrophilic Polyvinylpyrrolidone Coatings on Polypropylene with Enhanced Mechanical and Adhesion Properties. Macromol. Res. 26, 151–156 (2018). https://doi.org/10.1007/s13233-018-6031-2
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13233-018-6031-2