Summary
Current treatments for cancer and the central nervous system diseases are limited, partly due to the difficulties posed by the insolubility, poor distribution of drugs among cells and lack of selectivity of drugs, the inability of drugs to cross cellular barriers and blood brain barrier (BBB). Carbon nanotubes (CNTs) possess many distinct properties including good electronic properties, remarkably penetrating capability on the cell membrane, high drug-loading and pH-dependent therapeutic unloading capacities, thermal properties, large surface area and easy modification with molecules, which render them as a suitable candidate to deliver drugs to cancer and brain. CNTs as a drug delivery could achieve a high efficacy, enhance specificity and diminish side effects. Whereas CNTs have been primarily employed in cancer treatment, a few studies have focused on the treatment and diagnosis of the central nervous system diseases using CNTs. Here, we review the current progress of in vitro and in vivo researches of CNTs-based drug delivery to cancer involving CNTs-based tumor-targeted drug delivery systems (DDS), photodynamic therapy (PDT) and photothermal therapy (PTT). Meanwhile, we also review the current progress of in vitro and in vivo researches of CNTs-based drug delivery to brain.
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Moghimi SM, Hunter AC, Murray JC. Nanomedicine: current status and future prospects. FASEB J, 2005,19(3):311–330
Enayati M, Mobedi H, Hojjati-Emami S, et al. In situ forming PLGA implant for 90 days controlled release of leuprolide acetate for treatment of prostate cancer. Polym Advan Tech, 2017,28(7):867–875
Kim OY, Lee J, Gho YS. Extracellular vesicle mimetics: novel alternatives to extracellular vesicle-based theranostics, drug delivery, and vaccines. Semin Cell Dev Biol, 2016,67:74–82
Zhou D, Fang T, Lu LQ, et al. Neuroprotective potential of cerium oxide nanoparticles for focal cerebral ischemic stroke. J Huazhong Univ Sci Technolog Med Sci, 2016,36(4):480–486
Safari J, Zarnegar Z. Advanced drug delivery systems: Nanotechnology of health design A review. J Saudi Chem Soc, 2014,18(2):85–99
Pahuja R, Seth K, Shukla A, et al. Trans-blood brain barrier delivery of dopamine-loaded nanoparticles reverses functional deficits in parkinsonian rats. ACS Nano, 2015,9(5):4850–4871
Meng R, Li K, Chen Z, et al. Multilayer coating of tetrandrine-loaded PLGA nanoparticles: Effect of surface charges on cellular uptake rate and drug release profile. J Huazhong Univ Sci Technolog Med Sci, 2016,36(1):14–20
Cai Z, Zhang H, Wei Y, et al. Hyaluronan-inorganic nanohybrid materials for biomedical applications. Biomacromolecules, 2017,18(6):1677–1696
Iijima S. Helical microtubules of graphitic carbon. Nature, 1991,354(7):56
Ates M, Eker AA, Eker B. Carbon nanotube-based nanocomposites and their applications. J Adhes Sci Techno, 2017:1–21
Yang St, Guo W, Lin Y, et al. Biodistribution of pristine single-walled carbon nanotubes in vivo. J Phys Chem C, 2007,111(48):17761–17764
Chen D, Wang C, Nie X, et al. Photoacoustic imaging guided near-infrared photothermal therapy using highly water-dispersible single-walled carbon nanohorns as theranostic agents. Adv Funct Mater, 2014,24(42):6621–6628
Lekawa-Raus A, Gizewski T, Patmore J, et al. Electrical transport in carbon nanotube fibres. Scripta Mater, 2017,131:112–118
Li QP, Yan B. Multi-walled carbon nanotube-based ternary rare earth (Eu 3+, Tb 3+) hybrid materials with organically modified silica-oxygen bridge. J Colloid Interf Sci, 2012,380(1):67–74
Sun YW, Hernández I, Ghandour AJ, et al. Resonance Raman spectroscopy of carbon nanotubes: pressure effects on G-mode. High Pressure Res, 2014,34(2):191–197
Azqhandi MHA, Farahani BV, Dehghani N. Encapsulation of methotrexate and cyclophosphamide in interpolymer complexes formed between poly acrylic acid and poly ethylene glycol on multi-walled carbon nanotubes as drug delivery systems. Mater Sci Eng: C Mater Biol Appl, 2017,79:841–847
Karimi M, Solati N, Ghasemi A, et al. Carbon nanotubes part II: a remarkable carrier for drug and gene delivery. Expert Opin Drug Deliv, 2015,12(7):1089–105
Wang R, Cui H, Wang J, et al. Enhancing the antitumor effect of methotrexate in intro and in vivo by a novel targeted single-walled carbon nanohorn-based drug delivery system. RSC Adv, 2016,6(53):47272–47280
Martincic M, Tobias G. Filled carbon nanotubes in biomedical imaging and drug delivery. Expert Opin Drug Deliv, 2015,12(4):563–581
Raza K, Kumar D, Kiran C, et al. Conjugation of docetaxel with multiwalled carbon nanotubes and codelivery with piperine: Implications on pharmacokinetic profile and anticancer activity. Mol Pharm, 2016,13(7):2423–2432
Yang Z, Zhang Y, Yang Y, et al. Pharmacological and toxicological target organelles and safe use of single-walled carbon nanotubes as drug carriers in treating Alzheimer disease. Nanomedicine, 2010,6(3):427–441
Foillard S, Russier J, Seifert C, et al. Carbon nanotube-mediated delivery of budesonide to macrophages. RSC Advances, 2016,6(58):53282–53287
Roccatano D, Sarukhanyan E, Zangi R. Adsorption mechanism of an antimicrobial peptide on carbonaceous surfaces: A molecular dynamics study. J Chem Phys, 2017,146(7):074703
Raja G, Kim S, Yoon D, et al. 1H-NMR-based metabolomics studies of the toxicity of mesoporous carbon nanoparticles in Zebrafish (Danio rerio). B Kor Chem Soc, 2017,38(2):271–277
Zhao J, Liu X, Zhu Z, et al. Molecular insight into the enhancement of benzene-carbon nanotube interactions by surface modification for drug delivery systems (DDS). Appl Surf Sci, 2017,416:757–765
Xie L, Wang G, Zhou H, et al. Functional long circulating single walled carbon nanotubes for fluorescent/photoacoustic imaging-guided enhanced phototherapy. Biomaterials, 2016,103:219–228
Jingyi C, Xianrui Z, Larisa V, et al. Functionalized single-walled carbon nanotubes as rationally designed vehicles for tumor-targeted drug delivery. J Am Chem Soc, 2010,130(49):16778–16785
Jeyamohan P, Hasumura T, Nagaoka Y, et al. Accelerated killing of cancer cells using a multifunctional single-walled carbon nanotube-based system for targeted drug delivery in combination with photothermal therapy. Int J Nanomedicine, 2013,8:2653–2667
Yang W, Thordarson P, Gooding JJ, et al. Carbon nanotubes for biological and biomedical applications. Nanotechnology, 2007,18(41):412001
Murray AR, Kisin E, Leonard SS, et al. Oxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubes. Toxicology, 2009,257(3): 161–171
Wu W, Bian XC, Zhu ZS, et al. Covalently combining carbon nanotubes with anticancer agent: preparation and antitumor activity. ACS nano, 2009,3(9),2740–2750
Zhang YB, Li ZG, Chen T, et al. Mechanistic toxicity evaluation of uncoated and pEGylated single-walled carbon nanotubes in neuronal PC12 cells. ACS Nano, 2011,5(9): 7020–7033
Caoduro C, Hervouet E, Girard-Thernier C, et al. Carbon nanotubes as gene carriers: Focus on internalization pathways related to functionalization and properties. Acta Biomater, 2017,49:36–44
Li Z, Barros ALB, Soares DCF, et al. Functionalized single-walled carbon nanotubes: cellular uptake, biodistribution and applications in drug delivery. Int J Pharm, 2017,524(1-2):41–54
Yang T, Wu ZZ, Wang J, et al. A large-inner-diameter multi-walled carbon nanotube-based dual-drug delivery system with pH-sensitive release properties. J Mater Sci Mater Med, 2017,28:110
Kaur S, Mehra NK, Jain K, et al. Development and evaluation of targeting ligand-anchored CNTs as prospective targeted drug delivery system. Artif Cell Blood Su, 2017,45(2):242–250
Mehra NK, Jain NK. One platform comparison of estrone and folic acid anchored surface engineered MWCNTs for doxorubicin delivery. Mol Pharm, 2015,12(2):630–643
Cao X, Tao L, Wen S, et al. Hyaluronic acid-modified multiwalled carbon nanotubes for targeted delivery of doxorubicin into cancer cells. Carbohydr Res, 2015,405:70–77
Zheng LX, Tan L, Tan H, et al. Chitosan-functionalised single-walled carbon nanotube-mediated drug delivery of SNX-2112 in cancer cells. Nanotechnol Biomater, 2016,31(3):379–386
Li J, Pant A, Chin CF, et al. In vivo biodistribution of platinum-based drugs encapsulated into multi-walled carbon nanotubes. Nanomedicine, 2014,10:1465–1475
Liu Z, Rakhra K, Sherlock S, et al. Supramolecular stacking of doxorubicin on carbon nanotubes for in vivo cancer therapy. Angew Chem Int Ed, 2009,48:7668 -7672
Sui L, Gao P, Meng A, et al. Incorporation of cisplatin into PEG-wrapped ultrapurified large-inner-diameter MWCNTs for enhanced loading efficiency and release profile. Int J Pharm, 2014,471:157–165
Rieger C, Kaufmann A, Schendel D, et al. Characterization of different carbon nanotubes for the development of a mucoadhesive drug delivery system for intravesical treatment of bladder cancer. Int J Pharm, 2015,479:357–363
Yang Y, Liu J, Sun X, et al. Near-infrared light-activated cancer cell targeting and drug delivery with aptamer-modified nanostructures. Nano Res, 2015,9(1):139–148
Kazemi-Beydokhti A, Zeinali Heris S, Jaafari MR. Experimental investigation of thermal conductivity of medical nanofluids based on functionalised single-wall carbon nanotube and conjugated cisplatin. Micro Nano Lett, 2015,10(5):241–247
Liang X, Shang W, Chi C, et al. Dye-conjugated single-walled carbon nanotubes induce photothermal therapy under the guidance of near-infrared imaging. Cancer Lett, 2016,383(2):243–249
Robinson JT, Welsher K, Tabakman SM, et al. High performance in vivo near-IR (>1 mum) imaging and photothermal cancer therapy with carbon nanotubes. Nano Res, 2010,3(11):779–793
Zhou M, Liu S, Jiang Y, et al. Doxorubicin-loaded single wall nanotube thermo-sensitive hydrogel for gastric cancer chemo-photothermal therapy. Adv Funct Mater, 2015,25(29):4730–4739
Han H, Mann A, Ekstein D, et al. Breaking bad: the structure and function of the blood-brain barrier in epilepsy. AAPS J, 2017:1–16
Gao H, Pang Z, Jiang X. Targeted delivery of nano-therapeutics for major disorders of the central nervous system. Pharm Res, 2013,30(10):2485–2498
Costa PM, Bourgognon M, Wang JT, et al. Functionalised carbon nanotubes: From intracellular uptake and cell-related toxicity to systemic brain delivery. J Control Release ELEASE, 2016,241:200–219
Kafa H, Wang JTW, Rubio N, et al. Translocation of LRP1 targeted carbon nanotubes of different diameters across the blood-brain barrier in vitro and in vivo. J Control Release, 2016,225:217–229
Zhao D, Alizadeh D, Zhang L, et al. Carbon nanotubes enhance CpG uptake and potentiate antiglioma immunity. Clin Cancer Res, 2011,17(4):771–782
Tan JM, Foo JB, Fakurazi S, et al. Release behaviour and toxicity evaluation of levodopa from carboxylated single-walled carbon nanotubes. Beilstein J Nanotechnol, 2015,6:243–253
Khuloud T, MAH Al-Jamala, Gherardini L, et al. Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing. PNAS, 2011,108(27):10952–10957
Ying M, Zhan C, Wang S, et al. Liposome-based systemic glioma-targeted drug delivery enabled by all-d peptides. ACS Appl Mater Inte, 2016,8(44):29977–29985
Chen C, Duan Z, Yuan Y, et al. Peptide-22 and cyclic RGD functionalized liposomes for glioma targeting drug delivery overcoming BBB and BBTB. ACS Appl Mater Inte, 2017,9(7):5864–5873
Song MM, Xu HL, Liang JX, et al. Lactoferrin modified graphene oxide iron oxide nanocomposite for glioma-targeted drug delivery. Mate Sci Eng C, 2017,77:904–911
Wu P, Li S, Zhang H. Design real-time reversal of tumor multidrug resistance cleverly with shortened carbon nanotubes. Drug Des Devel Ther, 2014,8:2431–2438
Hu K, Li J, Shen Y, et al. Lactoferrin-conjugated PEG-PLA nanoparticles with improved brain delivery: in vitro and in vivo evaluations. J Control Release, 2009,134(1):55–61
Liu Z, Davis C, Cai W, et al. Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy. Proc Natl Acad Sci USA, 2008,105(5):1410–1415
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This project was supported by grants from the Fundamental Research Funds for the Central Universities, HUST (No. 2016YXZD043), and the National Science & Technology Pillar Program during the 12th Five-Year Plan Period, China (No. 2012BAI32B03).
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Guo, Q., Shen, Xt., Li, Yy. et al. Carbon nanotubes-based drug delivery to cancer and brain. CURR MED SCI 37, 635–641 (2017). https://doi.org/10.1007/s11596-017-1783-z
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DOI: https://doi.org/10.1007/s11596-017-1783-z