Abstract
A method for synthesizing new compounds capable of releasing NO within living organisms, namely, 2-azidoethyl derivatives of methylenebis(1-oxytriaz-1-ene 2-oxides) bearing one or few 2-azidoethyl moieties, was developed. The synthesis involves nucleophilic substitution of the bromine atoms of the parent 2-bromoethyl derivatives of methylenebis(1-oxytriaz-1-ene 2-oxides) with the azide group. Some of the synthesized compounds are of interest as promising energetic materials.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2010–2015, November, 2018.
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Smirnov, G.A., Gordeev, P.B., Nikitin, S.V. et al. N-(2-Azidoethyl) derivatives of methylenebis(1-oxytriaz-1-ene 2-oxides). Russ Chem Bull 67, 2010–2015 (2018). https://doi.org/10.1007/s11172-018-2322-1
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DOI: https://doi.org/10.1007/s11172-018-2322-1
Key words
- NO donors
- methylenebis(1-oxytriaz-1-ene 2-oxides)
- bis(2-bromoethyl) derivatives of methylenebis(1-oxytriaz-1-ene 2-oxides)
- tris(2-bromoethyl) derivatives of methyl enebis(1-oxytriaz-1-ene 2-oxides)
- bis(2-azidoethyl) derivatives of methylenebis(1-oxytriaz- 1-ene 2-oxides)
- tris(2-azidoethyl) derivatives of methylenebis(1-oxytriaz-1-ene 2-oxides)
- alkylation
- azidation
- nucleophilic substitution