Abstract
3,3-Bis(2-nitroxyethyl) derivatives of 1,1′-[methylenebis(oxy)]bis(triaz-1-ene 2-oxides) were synthesized by either nucleophilic substitution of the bromine atoms of parent 3,3-bis(2- bromoethyl) compounds or nitration of structurally related 3,3-bis(2-hydroxyethyl) derivatives. The synthesized compounds comprise two different NO donating moieties, namely, oxytriaz- 1-ene 2-oxide and nitrate groups, and, therefore, can be regarded as a new type of NO-donating agents.
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C. A. Velázquez, E. E. Knaus, J. Med. Chem., 2005, 48, 4061.
R. S. Nandurdikar, l. K. Keefer, A. E. MacIag, Z. Cao, J. E. Saavedra, Bioorg. Med. Chem., 2012, 20, 2025.
J. Kaur, A. Bhardwaj, Z. Haung, E. E. Knaus, D. Narang, T. Y. Chen, F. Plane, J. Med. Chem., 2012, 55, 7883.
V. P. Ananikov, E. A. Khokhlova, M. P. Egorov, A. M. Sakharov, S. G. Zlotin, A. V. Kucherov, L. M. Kustov, M. L. Gening, N. E. Nifantiev, Mendeleev Commun., 2015, 25,75.
S. G. Zlotin, A. M. Churakov, O. A. Luk’yanov, N. N. Makhova, A. Yu. Sukhorukov, V. A. Tartakovsky, Mendeleev Commun., 2015, 25,399.
S. G. Zlotin, A. M. Churakov, I. L. Dalinger, O. A. Luk’yanov, N. N. Makhova, A. Yu. Sukhorukov, V. A. Tartakovsky, Mendeleev Commun., 2017, 27, 5 35
G. A. Smirnov, P. B. Gordeev, S. V. Nikitin, G. V. Pokhvisneva, T. V. Ternikova, O. A. Luk’yanov, Russ. Chem. Bull., 2015, 64, 1057.
G. A. Smirnov, S. V. Nikitin, P. B. Gordeev, G. V. Pokhvisneva, T. V. Ternikova, O. A. Luk’yanov, Russ. Chem. Bull., 2015, 64, 2706.
G. V. Pokhvisneva, T. V. Ternikova, G. A. Smirnov, P. B. Gordeev, S. V. Nikitin, O. A. Luk’yanov, Russ. Chem. Bull., 2016, 65, 2650.
T. V. Ternikova, G. V. Pokhvisneva, G. A. Smirnov, S. V. Nikitin, P. B. Gordeev, O. A. Luk’yanov, Russ. Chem. Bull., 2016, 65, 2873.
G. V. Pokhvisneva, T. V. Ternikova, G. A. Smirnov, P. B. Gordeev, S. V. Nikitin, O. A. Luk’yanov, Russ. Chem. Bull., 2017, 66, 1234.
T. V. Ternikova, G. V. Pokhvisneva, G. A. Smirnov, P. B. Gordeev, S. V. Nikitin, O. A. Luk’yanov, Russ. Chem. Bull., 2017, 66, 2103.
G. A. Smirnov, P. B. Gordeev, S. V. Nikitin, Yu. V. Nelyubina, G. V. Pokhvisneva, T. V. Ternikova, O. A. Luk’yanov, Mendeleev Commun., 2017, 27,567.
S. V. Nikitin, G. V. Pokhvisneva, T. V. Ternikova, P. B. Gordeev, I. M. Chistokhvalov, G. A. Smirnov, O. A. Luk’yanov, Russ. Chem. Bull., 2018, 67, 1445.
P. B. Gordeev, G. A. Smirnov, S. V. Nikitin, G. V. Pokhvisneva, T. V. Ternikova, O. A. Luk’yanov, Russ. Chem. Bull., 2018, 67,85.
J. J. Talley, E. J. Martinez, K. D. Jerome, Pat. WO 2015/109017; http://worldwide.espacenet.com.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 1655–1661, September, 2018.
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Pokhvisneva, G.V., Gordeev, P.B., Nikitin, S.V. et al. 3,3-Bis(2-nitroxyethyl) derivatives of 1,1′-[methylenebis(oxy)]bis(triaz-1-ene 2-oxides) as a new type of NO donors. Russ Chem Bull 67, 1655–1661 (2018). https://doi.org/10.1007/s11172-018-2273-6
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DOI: https://doi.org/10.1007/s11172-018-2273-6