The cytokine profile of peripheral blood plasma was studied in rats with various behavioral characteristics after acute emotional stress (1-hour immobilization with simultaneous electrocutaneous stimulation). Under basal conditions the concentrations of pro-inflammatory (IL-1α, IL-1β, IL-2, IFN-γ, and granulocyte-monocyte CSF) and anti-inflammatory cytokines (IL-4 and IL-10) in the blood of active animals were higher than in passive specimens. Acute stress was accompanied by a decrease in the level of plasma cytokines in behaviorally active rats. Stressed passive specimens were characterized by the accumulation of a pro-inflammatory cytokine IL-1β and anti-inflammatory cytokine IL-4 in the peripheral blood. The observed differences in the cytokine profile of the blood in behaviorally passive and active rats under basal conditions and after a negative emotiogenic exposure can be related to the specifics of immune reactions and metabolic processes in animals with different prognostic resistance to similar stress factors.
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References
L. S. Kalinichenko, S. S. Pertsov, E. V. Koplik, and G. V. Pirogova, Bull. Exp. Biol. Med., 153, No. 5, 680-683 (2012).
S. A. Ketlinskii and A. S. Simbirtsev, Cytokines [in Russian], St. Petersburg (2008), p. 552.
E. V. Koplik, Vestn. Nov. Med. Tekhnol., 9, No. 1, 16-18 (2002).
S. V. Magaeva and S. G. Morozov, Neuroimmunophysiology [in Russian], Moscow (2005), p. 160.
S. S. Pertsov, E. V. Koplik, V. L. Stepanyuk, and A. S. Simbirtsev, Bull. Exp. Biol. Med., 148, No. 2, 196-199 (2009).
K. V. Sudakov, Emotional Stress: Theoretical and Clinical Aspects [in Russian], Volgograd (1997), p. 168.
J. Montoro, J. Mullol, I. Jauregui, et al., J. Investig. Allergol. Clin. Immunol., 19, Suppl. 1, 40-47 (2009).
S. M. Opal and V. A. DePalo, Chest, 117, No. 4, 1162-1172 (2000).
F. Tausk, I. Elenkov, and J. Moynihan, Dermatol. Ther., 21, No. 1, 22-31 (2008).
A. V. Turnbull and C. L. Rivier, Physiol. Reviews, 79, No. 1, 1-71 (1999).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 10, pp. 426-429, October, 2013
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Kalinichenko, L.S., Koplik, E.V. & Pertsov, S.S. Cytokine Profile of Peripheral Blood in Rats with Various Behavioral Characteristics during Acute Emotional Stress. Bull Exp Biol Med 156, 441–444 (2014). https://doi.org/10.1007/s10517-014-2369-4
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DOI: https://doi.org/10.1007/s10517-014-2369-4