Changes in the blood cytokine profile in rats with various parameters of behavior were studied under conditions of 5-day starvation not followed by the recovery period or with subsequent normalization of food intake. Metabolic stress had no effect on the content of most cytokines. The concentration of pro- and anti-inflammatory cytokines in blood plasma of rats was shown to increase significantly by the end of a 5-day recovery period after food deprivation. These changes in behaviorally passive specimens were more pronounced than in active animals. Therefore, differences in the strain of immune reactions in mammals with different prognostic resistance to extreme factors are most pronounced during the post-stress period. These data illustrate the necessity of an individual approach to studying the systemic organization of physiological functions under normal and pathological conditions.
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Kalinichenko LS, Koplik EV, Pertsov SS. Cytokine profile of peripheral blood in rats with various behavioral characteristics during acute emotional stress. Bull. Exp. Biol. Med. 2014;156(4):441-444.
Koplik EV. A method for evaluation of the criterion of rat resistance to emotional stress. Vestn. Nov. Med. Tekhnol. 2002;9(1):16-18. Russian.
Koplik EV, Pertsov SS, Kalinichenko LS. Effect of interleukin-1β on peripheral blood leukocytes in rats with various behavioral characteristics during acute stress. Bull. Exp. Biol. Med. 2014;156(4):435-440.
Mamylina NV, Pavlova VI. Physiological aspects of animal behavior under conditions of emotional stress. Chelyabinsk, 2013. Russian.
Pertsov SS. Rat behavior after light regime shift and melatonin treatment. Ross. Fiziol. Zh. 2005;91(7):802-809. Russian.
Pertsov SS. Role of the hypothalamic suprachiasmatic nucleus in the effect of melatonin on the thymus, adrenal glands, and spleen in rats. . Bull. Exp. Biol. Med. 2006;141(4):383-386.
Pertsov SS, Koplik EV, Kalinichenko LS. Intensity of oxidative and antioxidant processes in the brain of rats with various behavioral characteristics during acute stress. Bull. Exp. Biol. Med. 2011;152(1):1-4.
Podsevatkin VG, Bochkareva NV, Kiryukhina SV, Podsevatkina SV. The role of antioxidants, antihypoxants, and immunomodulators in correction of animal behavioral disorders under conditions of chronic experimental stress. Teoret. Priklad. Aspekty Sovremen. Nauki. 2015;(8-1):134-137. Russian.
Sudakov KV, Ivanova EA, Koplik EV, Kotov AV, Kravtsov AN, Mescheryakov AF, Pertsov SS, Sotnikov SV, Tolpigo SM, Umriukhin AE, Umriukhin PE. Immune Linkl in the System Organization of Behaviour. Uspekhi Fiziol. Nauk. 2011;42(3):81-96. Russian.
Sudakov KV, Kotov AV, Pertsov SS. Experimental approaches to individual medicine: the dependence of drug effects on the type of animal behavior. Vestn. Ural. Med. Akad. Nauki. 2004;(1):51-57. Russian.
Khnychenko LK, Sapronov NS. Stress and its role in the development of pathological processes. Obzory po Klin. Farmakol. Lek. Ter. 2003;2(3):2-15. Russian.
Sharanova NE, Pertsov SS, Kirbaeva NV, Toropygin IY, Kalinichenko LS, Gapparov MM. Proteomic study of rat hippocampus under conditions of emotional stress.. Bull. Exp. Biol. Med. 2014;156(5):595-597.
Assaf AM, Al-Abbassi R, Al-Binni M. Academic stressinduced changes in Th1- and Th2-cytokine response. Saudi Pharm. J. 2017;25(8):1237-1247.
Pertsov SS, Koplik EV, Stepanyuk VL, Simbirtsev AS. Blood cytokines in rats with various behavioral characteristics during emotional stress and treatment with interleukin-1beta. Bull. Exp. Biol. Med. 2009;148(2):196-199.
Yang P, Gao Z, Zhang H, Fang Z, Wu C, Xu H, Huang QJ. Changes in proinflammatory cytokines and white matter in chronically stressed rats. Neuropsychiatr. Dis. Treat. 2015;11:597-607.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 10, pp. 417-420, October, 2018
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Kirbaeva, N.V., Evstratova, V.S., Riger, N.A. et al. Blood Cytokine Profile in Rats with Different Behavioral Characteristics after Metabolic Stress. Bull Exp Biol Med 166, 432–435 (2019). https://doi.org/10.1007/s10517-019-04366-7
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DOI: https://doi.org/10.1007/s10517-019-04366-7