We studied the effect of acute emotional stress and exogenous IL-1β (5 μg/kg intraperitoneally) on the cytokine profile of blood serum in Wistar rats with various behavioral characteristics in the open-field test. Blood level of proinfl ammatory cytokine IL-1β decreased in behaviorally passive rats, but increased in active animals after simultaneous immobilization and electrocutaneous stimulation. These changes refl ect the opposite immune responses to a similar stress exposure in rats with different emotional reactivity. Poststress variations in the concentration of circulating IL-1β differed in rats receiving exogenous IL-1β. Blood cytokine concentration decreased in behaviorally active rats, but remained unchanged in passive animals that were exposed to immobilization and electrocutaneous stimulation after pretreatment with IL-1β. Emotional stress and injection of IL-1β had no effect on blood level of an anti-infl ammatory cytokine IL-4 in rats. Our results indicate that rats with various behavioral parameters are characterized by significant differences in the cytokine profile of blood serum under conditions of emotional stress and treatment with IL-1β. These data illustrate the specific functional features of immune mechanisms, which provide an individual resistance of rats to the same stress exposure.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
S. A. Ketlinskii and A. S. Simbirtsev, Cytokines [in Russian], St. Petersburg (2008).
E. V. Koplik, Vestn. Nov. Med. Tekhnol., 9, No. 1, 16–18 (2002).
S. S. Pertsov, V. M. Abramov, A. S. Sosnovskii, et al., Byull. Eksp. Biol. Med., 117, No. 3, 238–239 (1994).
S. S. Pertsov, T. S. Balashova, A. A. Kubatiev, et al., Ibid., 120, No. 9, 244–247 (1995).
S. S. Pertsov, A. S. Sosnovskii, and G. V. Pirogova, Ibid., 124, No. 7, 32–35 (1997).
K. V. Sudakov, A. V. Kotov, and S. S. Pertsov, Vestn. Ural’sk. Med. Akademich. Nauki, No. 1, 51–57 (2004).
S. K. Sudakov, Byull. Eksp. Biol. Med., 89, No. 6, 662–664 (1980).
A. Gadek-Michalska, A. J. Bugajski, and J. Bugajski, J. Physiol. Pharmacol., 59, No. 3, 563–575 (2008).
J. P. Godbout and R. Glaser, J. Neuroimmune Pharmacol., 1, No, 4, 421–427 (2006).
L. B. LeMay, A. J. Vander, and M. J. Kluger, Physiol. Behav., 47, 957–961 (1990).
H. A. Marques, G. Cizza, and E. Sternberg, Rev. Bras. Psiquiatr., 29, Suppl. 1, S27–S32 (2007).
T. W. Pace, T. C. Mletzko, O. Alagbe, et al., Am. J. Psychiatry, 163, No 9, 1630–1633 (2006).
W. W. Pace, F. Hu, and A. H. Miller, Brain Behav. Immun., 21, No. 1, 9–19 (2007).
J. H. Persoons, K. Schornagel, J. Breve, et al., Am. J. Respir. Crit. Care Med., 152, 619–624 (1995).
J. M. Weiss, S. K. Sundar, K. J. Becker, et al., J. Clin. Psychiatry., 50, 43–53 (1989).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, No. 8, pp. 161–165, August, 2009
Rights and permissions
About this article
Cite this article
Pertsov, S.S., Koplik, E.V., Stepanyuk, V.L. et al. Blood Cytokines in Rats with Various Behavioral Characteristics during Emotional Stress and Treatment with Interleukin-1β. Bull Exp Biol Med 148, 196–199 (2009). https://doi.org/10.1007/s10517-009-0668-y
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-009-0668-y