Summary.
The accumulation of oxidized proteins is known to be linked to some severe neurodegenerative diseases like Alzheimer’s, Parkinson’s and Huntington’s disease. Furthermore, the aging process is also accompanied by an ongoing aggregation of misfolded and damaged proteins. Therefore, mammalian cells have developed potent degradation systems, which selectively degrade damaged and misfolded proteins. The proteasomal system is largely responsible for the removal of oxidatively damaged proteins form the cellular environment. Not only cytosolic proteins are prone to oxidative stress, also nuclear proteins are readily oxidized. The nuclear proteasomal system is responsible for the degradation of these proteins. This review is focused on the specific degradation of oxidized nuclear proteins, the role of the proteasome in this process and the regulation of the nuclear proteasomal system under oxidative conditions.
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Abbreviations
- AD:
-
Alzheimer’s disease
- ADP:
-
adenosinediphosphate
- AGE:
-
advanced glycosilation end products
- ATP:
-
adenosinetriphosphate
- DNA:
-
desoxyribonucleic acid
- EGF:
-
epidermal growth factor
- ER:
-
endoplasmic reticulum
- G6PD:
-
glucose-6-phosphate dehydrogenase
- GAPDH:
-
glyceraldehyde-3-phosphate dehydrogenase
- HD:
-
Huntington’s disease
- HNE:
-
4-hydroxynonenal
- IFγ:
-
interferon γ
- MDA:
-
malondialdehyde
- MHC-I:
-
major histocompatibility complex class I
- NAD+ :
-
nicotinamide adenosine dinucleotide
- NLS:
-
nuclear localization signal
- pADPR:
-
poly-(ADP-ribose)
- PARP:
-
poly-(ADP-ribose) polymerase
- PD:
-
Parkinson’s disease
- RNS:
-
reactive nitrogen species
- ROS:
-
reactive oxygen species
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Voss, P., Grune, T. The nuclear proteasome and the degradation of oxidatively damaged proteins. Amino Acids 32, 527–534 (2007). https://doi.org/10.1007/s00726-006-0428-5
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DOI: https://doi.org/10.1007/s00726-006-0428-5