Summary.
A series of peptide and dipeptide derivatives conjugated with a 1,2,3-triazolo[4,5-d]pyrimidinedione residue were synthesized. The new compounds were evaluated in vitro for cytotoxicity against HAV-27 and HSV-1 and showed moderate activity. The prepared compounds were tested for antimicrobial activity against four different bacterial species, and they displayed different degrees of antibacterial activities or inhibitory actions.
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Part V: Ali OM, Abdel-Rahman AA-H (2007) Monatsh Chem (in press)
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Abdel-Rahman, AH. Amino Acid Derivatives, VI [1]: Synthesis, Antiviral, and Antimicrobial Evaluation of α-Amino Acid Esters Bearing a 1,2,3-Triazolo[4,5-d]pyrimidinedione Side Chain. Monatsh. Chem. 139, 61–68 (2008). https://doi.org/10.1007/s00706-007-0745-8
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DOI: https://doi.org/10.1007/s00706-007-0745-8