Abstract
In order to gain further insight into hypopituitarism, that ensues moderate to severe traumatic brain injury (TBI), a group of experts actively working in the field gathered to exchange recent data and concepts. The objective arising from the meeting was to enhance the awareness of both medical specialists and health care administrators on the problem, whose prevalence is higher than previously thought. Guidelines for the diagnosis and management of TBI-mediated hypopituitarism were produced.
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Escamilla RF, Lisser H. Simmonds disease. J Clin Endocrinol 1942, 2: 65–96.
Porter RJ, Miller RA. Diabetes Insipidus following closed head injury. J Neurol Neurosurg Psychiatriy 1946, 11: 528–62.
Witter M, Tasher R. Hypophysar-hypothalamische kramkheitsbilder mach stumptem schadeltrauma. Fortschr Neurol Psychiatr 1957, 25: 523–46.
Cyran E. Hypophysenschadigung durch Schadelbasisfraktur. Deutch Med Wochenschrift 1918, 44: 1261–70.
Vance ML. Hypopituitarism. New Engl J Med 1994, 330: 1651–61.
Edwards OM, Clark JDA. Post-traumatic hypopituitarism. Six cases and review of the literature. Medicine 1986, 65: 281–90.
Altman R, Pruzanski W. Post-traumatic hypopituitarism. Ann Intern Med 1961, 55: 149–54.
Rudman D, Fleischer AS, Kutner MH, Raggio JF. Suprahy-pophyseal hypogonadism and hypothyroidism during prolonged coma and head trauma. J Clin Endocrinol Metab 1977, 45: 747–53.
Fleischer AS, Rudman DR, Payne NS, Tindall GT. Hypothalamic hypothyroidism and hypogonadism in prolonged traumatic coma. J Neurosurg 1978, 49: 650–7.
Castaner M F, Ayma J, Martinez MJ, Vilardell E. Diabetes insipida e hipopituitarismo postraumáticos. Consideraciones diagnósticas a propósito de tres casos. Med Clin (Barc) 1981, 78: 358–62.
Eiholzer U, Zachman M, Gnehm HE, Prader A. Recovery from post-traumatic anterior pituitary insufficiency. Eur J Pediatr 1986, 145: 128–30.
Gunn IR, Beastall GH, Matthews DM, Bath JCJL. Post-traumatic hypothalamic-pituitary dysfunction presenting with biochemical features of primary hypothyroidism. Ann Clin Biochem 1991, 28: 327–30.
Mazaux JM, Richer E. Rehabilitation after traumatic brain injury in adults. Disabil Rehabil 1998, 20: 435–47.
Colantonio A, Dawson DR, McLellan BA. Head injury in young adults, long-term outcome. Arch Phys Med Rehabil 1998, 79: 550–8.
Morton MV, Wehman P. Psychosocial and emotional sequelae of individuals with traumatic brain injury: a literature review and recommendations. Brain Inj 1995, 9: 81–92.
Benvenga S, Le Giudice F, Campenni A, Longo M, Trimarchi F. Post-traumatic selective hypogonadotropic hypogonadism. J Endocrinol Invest 1997, 20: 675–80.
Levin HS, Gary HE, Eisenberg HM et al. Neurobehavioral outcome 1 year after severe head injury. Experience of the Traumatic Coma Data Bank. J Neurosurg 1990, 73: 699–709.
Lopez-Guzman A, Salvador J, Albero R et al. Selective growth hormone deficiency of hypothalamic origin following severe head injury. Acta Pediatr 1992, 81: 698–9.
McGauley GA, Cuneo RC, Salomon F, Sonksen PH. Psychological well-being before and after growth hormone treatment in adults with growth hormone deficiency. Horm Res 1990, 33 (suppl 4): 52–4.
Ceballos R. Pituitary changes in head trauma. Analysis of 102 consecutive cases of head injury. Ala J Med Sci 1966, 3: 185–98.
Kornblum RN, Fisher RS. Pituitary lesions in craniocerebral injuries. Arch Pathol 1969, 88: 242–8.
Crompton MR. Hypothalamic lesions following closed head injury. Brain 1971, 94: 165–72.
Daniel PM, Treip CS. The pathology of the pituitary gland in head injury. Modern Trends in Endocrinology 1961, 55–68.
Benvenga S, Campenni A, Ruggeri RM, Trimarchi F. Hypopituitarism secondary to head trauma. J Clin Endocrinol Metab 2000, 85: 1353–61.
Kelly DF, Gaw IT, Cohan P, Berman N, Swerdloff R, Wang C. Hypopituitarism following traumatic brain injury and aneu-rismal subarachnoid hemorrhage: a preliminary report. J Neurosurg 2000, 93: 743–52.
Springer J, Chollet A. A traumatic car crash. Lancet 2001, 357: 1848.
Lieberman SA, Oberoi AL, Gilkison CR, Masel BE, Urban RJ. Prevalence of neuroendocrine dysfunction in patients recovering from traumatic brain injury. J Clin Endocrinol Metab 2001, 86: 2752–6.
Ghigo E, Masel B, Aimaretti G et al. Consensus guidelines for hypopituitarism following traumatic brain injury. Submitted.
Casanueva FF, Leal A, Koltowska M, Jonsson P, Goth MI. Traumatic brain injury as a relevant cause of growth hormone deficiency in adults. A KIMS based study. Arch Phys Med Rehabil 2004 (in press).
G. Aimaretti, M.R. Ambrosio, C. Di Somma et al. Traumatic brain injury and subarachnoid haemorrhage are conditions at high risk for hypopituitarism. Screening study at 3 months after the brain injury. Clin Endocrinol (Oxf) 2004, 61: 320–6.
Benvenga S, Vigo T, Ruggeri RM et al. Severe head trauma in patients with unexplained central hypothyroidism. Am J Med 2004, 116: 767–71
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The Athens TBI and Hypopituitarism Study Group: Casanueva F.F, University of Santiago de Compostela, Santiago de Com-postela, Spain; Ghigo E., University of Turin, Turin, Italy; Popovic V., University Clinical Center, Belgrade, Serbia; Agelopoulos N., Hippocration Hospital, Athens, Greece; Aimaretti G., University of Turin, Turin, Italy; Baldelli R., University of Piemonte Orientale “Amedeo Avogadro,” Italy; Baptista F., Hospital Santa Maria, Lisbon, Portugal; Carvalho D., Hospital de S. João, Porto, Portugal; Colao A., University “Federico II”, Naples, Italy; Di Som-ma C., University “Federico II”, Naples, Italy; Djurovic B., Clinical Center of Serbia, Belgrade, Serbia; Cordero J.F.C., Hospital Universitario Virgen del Rocio, Seville, Spain; Gurlek A., Haceteppe University School of Medicine, Ankara, Turkey; Kelestimur F., Erciyes University Medical School, Kayseri, Turkey; Kelly D.F., Department of Neurosurgery, UCLA, Los Angeles, USA; Leal Cerro A., Hospital Universitario Virgen del Rocio, Sevilla, Spain; Leon-Carrion J., University of Seville, Seville, Spain; Maric N.P., Clinical Centre of Serbia, Belgrade, Serbia; Greece; Masel B.E., Transitional Learning Center, Galveston, USA; Movalilar S., Istanbul Faculty of Medicine, Istanbul, Turkey; Murillo-Cabezas F., Hospital Universitario Virgen Del Rocio, Seville, Spain; Perino C., Presidio Ospedaliero Ausiliatrice, Turin, Italy; Pavlovic D., Institute of Neurology, Clinical Center of Serbia, Belgrade, Serbia; Selcuklu A., Department of Neurosurgery, Erciyes University, Kayseri, Turkey; Tolis G. Hippocratio Hospital, Athens, Greece; Touraine P., Necker Hospital, Paris, France; Tsagarakis S., Athens Polyclinic, Athens, Greece; Urban R., University of Texas, Medical Branch, Galveston, USA; Vilarinho A., Hospital de S. João, Porto, Portugal.
An erratum to this article is available at http://dx.doi.org/10.1007/BF03345392.
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Casanueva, F.F., Ghigo, E., Popovic, V. et al. Hypopituitarism following traumatic brain injury (TBI): A guideline decalogue. J Endocrinol Invest 27, 793–795 (2004). https://doi.org/10.1007/BF03347526
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DOI: https://doi.org/10.1007/BF03347526