Abstract
This randomized controlled study was designed to test the efficacy and safety of percutaneous ultrasound (US)-guided laser photocoagulation (PLP) for treatment of subjects with compressive symptoms due to benign thyroid nodules and/or at high surgical risk. Twenty six subjects were randomized to the intervention (no. 13, age 68±3 yr, mean±SEM) or observation (no. 13, age 71±2 yr) groups. In the control group, the volume of nodules did not significantly change over the 30 week period of observation. In the intervention group, median nodule volume at baseline was 8.2 ml (range 2.8–26.9) and was not significantly different from that of the control group. Nodules decreased significantly (p<0.0001) by 22% after 2 weeks (6.5ml; range 2.4–16.7) and by 44% after 30 weeks (4.6 ml; range 0.69–14.2). Energy given was correlated (p<0.05) with the reduction of thyroid nodule volume. All patients tolerated the treatment well and reported relief from compressive and cosmetic complaints (p<0.05). At the time of enrolment 7/13 (54%) and 6/13 (46%) of patients in the intervention and control groups, respectively, had sub clinical hyperthyroidism. PLP normalized thyroid function at 6 and 30 weeks after treatment. In conclusion, PLP is a promising safe and effective procedure for treatment of benign thyroid nodules in patients at high surgical risk.
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Guglielmi R, Pacella CM, Bianchini A, et al. Percutaneous ethanol injection treatment in benign thyroid lesions: role and efficacy. Thyroid 2004, 14: 125–31.
Guglielmi R, Pacella CM, Dottorini ME, Papini E. Severe thyrotoxicosis due to hyperfunctioning liver metastasis from follicular carcinoma: treatment with 1311 and interstitial laser ablation. Thyroid 1999, 2: 173–6.
Papini E, Guglielmi R, Bizzarri G, Pacella CM. US-guided laser thermal ablation for treatment of benign thyroid nodules. Endocr Pract 2004, 10: 276–83.
Pacella CM, Bizzarri G, Spiezia S, et al. Thyroid tissue: US-guided percutaneous laser thermal ablation. Radiology 2004, 232: 272–80.
Spiezia S, Vitale G, Di Somma C, et al. Ultrasound-guided laser thermal ablation in the treatment of autonomous hyperfunctioning thyroid nodules and compressive nontoxic nodular goiter. Thyroid 2003, 13: 941–7.
Dossing H, Bennedbaek FN, Hegedus L. Ultrasound-guided interstitial laser photocoagulation of an autonomous thyroid nodule: the introduction of a novel alternative. Thyroid 2003, 13: 885–8.
Dossing H, Bennedbaek FN, Hegedus L. Effect of ultrasound-guided interstitial laser photocoagulation on benign solitary solid cold thyroid nodules — a randomised study. Eur J Endocrinol 2005, 152: 341–5.
Pacella CM, Bizarri G, Guglielmi R, et al. Thyroid tissue: US-guided percutaneous interstitial laser ablation: a feasibility study. Radiology 2000, 217: 673–7.
Brauer VF, Eder P, Miehle K, Wiesner TO, Hasenclever H, Paschhke R. Interobserver variation for ultrasound determination of thyroid nodule volumes. Thyroid 2005, 15: 1169–75.
Glantz SA, Slinker BK. Primer of applied regression and analysis of variance. 2nd ed. New York: McGraw-Hill. 2001, 418–556.
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Gambelunghe, G., Fatone, C., Ranchelli, A. et al. A randomized controlled trial to evaluate the efficacy of ultrasound-guided laser photocoagulation for treatment of benign thyroid nodules. J Endocrinol Invest 29, RC23–RC26 (2006). https://doi.org/10.1007/BF03347368
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DOI: https://doi.org/10.1007/BF03347368