Abstract
The influence of dietary nicotinamide deficiency on lead intoxication in young developing rats was investigated. The Pb induced an increase in brain dopamine and noradrenaline, inhibition in blood δ-aminolevulinic acid dehydratase activity, an elevation in urinary excretion of δ-aminolevulinic acid and blood and tissue uptake of Pb were significantly more marked in animals maintained on a nicotinamide-deficient diet than those fed a nicotinamide-sufficient diet. The nicotinamide deficiency may enhance the susceptibility to Pb intoxication possible by enhancing the absorption of Pb and altering nicotinic acid metabolism.
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J. Dobbing, inChemistry and Brain Development, R. Paoletti and A. N. Davision, eds., Plenum, New York, NY, 1971, p. 339.
O. J. David, S. P. Hoffman, J. Sverd, and J. Clark,J. Abnorm. Child. Psychol. 5, 405 (1977).
R. L. Bornschien, D. A. Fox, and I. A. Michaelson,Toxicol. Appl. Pharmacol. 40, 577 (1979).
S. K. Tandon, S. J. S. Flora, and S. Singh,Ind. J. Med. Res. 80, 444 (1984).
L. B. Sasser, G. G. Hall, G. R. Bratton, and J. Zmudzki,J. Nutr. 114, 1816 (1984).
S. J. S. Flora and R. P. Sharma,Biol. Trace Elem. Res. 10, 137 (1986).
S. Caccuri and A. N. Cesaro,Rass. Med. Ind. 13, 317 (1942).
C. Sadavongvivad,Br. J. Pharmacol. 38, 353 (1970).
R. D. Haubrich and J. S. Denzer,Anal. Biochem. 55, 306 (1973).
J. R. Davis, R. H. Abrahams, W. T. Fishbein, and E. A. Fabrega,Arch. Environ. Health 17, 164 (1968).
A. Berlin and K. H. Schaller,Z. Klin. Chem. Clin. Biochem. 12, 389 (1974).
D. W. Hessel,At. Absorp. Newslett. 7, 55 (1968).
D. W. Yeager, J. Cholak, and E. W. Henderson,Environ. Sci. Technol. 5, 1020 (1971).
M. K. Shellenberger,Neurotoxicology 5, 177 (1984).
E. K. Silbergeld and A. M. Goldberg,Neuropharmacology 14, 431 (1975).
T. C. Dubas, A. Stevenson, R. L. Singhal, and P. D. Hridina,Toxicology 9, 185 (1978).
M. W. Sauerhoff and J. R. Michaelson,Science 182, 1022 (1973).
T. J. Sobotka, R. E. Brodie, and M. P. Cook,Toxicology 5, 175 (1975).
I. A. Michaelson, R. D. Greenland, and W. Roth,Pharmacologist 16, 336 (1974).
E. K. Silbergeld and J. J. Chisolm,Science 192, 153 (1976).
P. D. Hridina, D. A. V. Peters, and R. L. Singhal,Res. Comm. Chem. Pathol. Pharmacol. 15, 483 (1976).
S. S. Caccuri,Folia Med. 26, 345 (1940).
A. de Bruin,Arch. Environ. Health 23, 249 (1971).
A. Gajdos, M. Gajdos-Torok, and G. Danieli,Rev. Franc. Etud. Clin. Biol. 6, 888 (1961).
G. Bilski-Pasquier, C. Boudene, and A. Gajdos,Press Med. 73, 2741 (1965).
R. Sundstrom, N. C. Conradi, and P. Sourander,Acta Neuropathol. 60, 1 (1983).
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Flora, S.J.S., Tandon, S.K. Influence of dietary deficiency of nicotinamide on lead toxicity in young rats. Biol Trace Elem Res 14, 143–151 (1987). https://doi.org/10.1007/BF02795604
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DOI: https://doi.org/10.1007/BF02795604