Abstract
A new method for numerical deconvolution is described, for use in calculating drug input rates. The method is based on the least-squares criterion and is applicable when the input function can be assumed to take a prescribed form. In particular, an exponential input function and an input function derived from the cube-root dissolution law are considered. The stability of the method to data noise is shown by means of examples, using simulated data.
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Cutler, D.J. Numerical deconvolution by least squares: Use of prescribed input functions. Journal of Pharmacokinetics and Biopharmaceutics 6, 227–241 (1978). https://doi.org/10.1007/BF01312264
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DOI: https://doi.org/10.1007/BF01312264