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L. Z. Benet. General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics.J. Pharm. Sci. 61:536–541 (1972).
L. Michaelis and M. L. Menten. Die Kinetik der Invertinwirkung.Biochem. Z. 49:333–369 (1913).
A. R. DiSanto and J. G. Wagner. Pharmacokinetics of highly ionized drugs. III. Methylene blue-blood levels in the dog and tissue levels in the rat following intravenous injection.J. Pharm. Sci. 61:1090–1094 (1972).
J. G. Wagner.Biopharmaceutics and Relevant Pharmocokinetics, Drug Intelligence Publications, 1st ed., Hamilton, Ill., 1971, pp. 302–317.
A. J. Sedman and J. G. Wagner. Quantitative pooling of Michaelis-Menten equations with parallel metabolite formation paths.J. Pharmacokin. Biopharm. 2:149–160 (1974).
K. B. Bischoff, R. L. Dedrick, D. S. Zaharko, and J. A. Longstreth. Methotrexate pharmacokinetics.J. Pharm. Sci. 60:1128–1133 (1971).
J. C. K. Loo and S. Riegelman. A new method for calculating intrinsic absorption rates of drugs.J. Pharm. Sci. 57:918–928 (1968).
J. G. Wagner. Application of the Loo-Riegelman absorption method.J. Pharmacokin. Biopharm. 3:51–67 (1975).
J. G. Wagner and E. Nelson. Percent absorbed time plots derived from blood level and/or urinary excretion data.J. Pharm. Sci. 52:610–611 (1963).
J. G. Wagner. Application for the Wagner-Nelson absorption method to the two compartment open model.J. Pharmacokin. Biopharm. 2:469–486 (1974).
K. S. Albert, A. J. Sedman, and J. G. Wagner. Pharmacokinetics of orally administered acetaminophen in man.J. Pharmacokin. Biopharm. 2:381–393 (1974).
M. Rowland. Influence of route of administration on drug bioavailability.J. Pharm. Sci. 67:70–74 (1972).
K. S. Albert, M. R. Hallmark, E. Sakmar, D. J. Weidler, and J. G. Wagner. Pharmacokinetics of diphenhydramine in man.J. Pharmacokin. Biopharm. 3:159–170 (1975).
J. G. Wagner. Method of estimating relative absorption of a drug in a series of clinical studies in which blood levels are measured after single and/or multiple doses.J. Pharm. Sci. 56:652–653 (1967).
A. Rescigno and G. Segre.Drug and Tracer Kinetics, Blaisdell, Waltham, Mass., 1966, p. 102.
L. Z. Benet and C.-W. N. Chiang. The use of deconvolution methods in pharmacokinetics. InAbstracts of Papers presented at the 13thNational Meeting of the APhA Academy of Pharmaceutical Sciences, Chicago, November 5–9, 1972, Vol. 2, No. 2, pp. 169–171.
J. Fried and S. Zeitz. Curve fitting by spline and Akima methods: Possibility of interpolation errors and its suppression.Phys. Biol. Med. 18:550–558 (1973).
AUTOAN, a Time-Sharing Digital Computer Program, available from Publication Distribution Service, 615 East University Avenue, Ann Arbor, Mich. 48106.
E. Krüger-Thiemer. Formal theory of drug dosage regimens. I.J. Theor. Biol. 13:212 (1966).
W. J. Jusko, S. J. Szefler, and A. L. Goldfarb. Pharmacokinetic design of digoxin dosage regimens in relation to renal function.J. Clin. Pharmacol. 14:525–535 (1974).
J. G. Wagner, J. I. Northam, G. D. Alway, and O. S. Carpenter. Blood levels of drug at the equilibrium state after multiple dosing.Nature 207:1301–1302 (1965).
J. G. Wagner. Properties of the Michaelis-Menten equation and its integrated form which are useful in pharmacokinetics.J. Pharmacokin. Biopharm. 1:103–121 (1973).
C. A. M. Van Ginneken, J. M. Van Rossum, and H. L. J. M. Fleuren. Linear and nonlinear kinetics of drug elimination. I. Kinetics on the basis of a single capacity-limited pathway of elimination with and without simultaneous supply-limited elimination.J. Pharmacokin. Biopharm. 2:395–415 (1974).
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Wagner, J.G. Do you need a pharmacokinetic model, and, if so, which one?. Journal of Pharmacokinetics and Biopharmaceutics 3, 457–478 (1975). https://doi.org/10.1007/BF01059477
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DOI: https://doi.org/10.1007/BF01059477