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Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics

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  • © 2013

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Overview

Editors:
  1. Hae Won Kim

    1. Brown University, Barrington, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. A. Gerson Greenburg

    1. Brown University, Barrington, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Focus on Hemoglobin-based oxygen carriers (HBOCs)
  • Up to date information on progress of existing products, new emerging products/technologies
  • In-depth treatise covering rationale, scientific and clinical basis, ideal characteristics of HBOCs, approaches to HBOC products, scale up and manufacturing, preclinical and clinical studies for safety and efficacy evaluations, current challenges and future directions
  • Includes supplementary material: sn.pub/extras

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About this book

Currently, hemoglobin (Hb)-based oxygen carriers (HBOCs) are leading candidates as red blood cell substitutes. In addition, HBOCs are also potential oxygen therapeutics for treatment of patients with critical ischemic conditions due to atherosclerosis, diabetes and other conditions. This book will provide readers a comprehensive review of topics involved in the HBOC development. It focusses on current products and clinical applications as well as on emerging technologies and future prospects.

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Table of contents (39 chapters)

  1. Front Matter

    Pages i-xxiii
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  2. Introduction and Scientific Principles

    1. Front Matter

      Pages 1-1
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    2. From Hemoglobin Based Oxygen Carrier to Oxygen Therapeutics, Blood Substitutes, Nanomedicine and Artificial Cells

      • Thomas Ming Swi Chang
      Pages 3-26
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    3. From the Atmosphere to the Mitochondrion: The Oxygen Cascade

      • George P. Biro
      Pages 27-53
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    4. Biochemistry of Hemoglobin

      • Andrea Mozzarelli, Stefano Bruno, Luca Ronda
      Pages 55-73
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    5. The Role of Blood and Plasma Viscosity in Restoring Oxygen Delivery Capacity

      • Amy G. Tsai, Judith Martini, Beatriz Y. Salazar Vázquez, Pedro Cabrales, Seetharama A. Acharya, Marcos Intaglietta
      Pages 75-93
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  3. Hemorrhagic Shock and Current Treatments

    1. Front Matter

      Pages 95-95
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    2. Pathophysiology of Hemorrhagic Shock and Resuscitation

      • Fredric M. Pieracci, Walter L. Biffl
      Pages 97-116
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    3. Allogeneic Blood Transfusion for Surgical and Traumatic Hemorrhage

      • Mercy Kuriyan, Jeffrey L. Carson
      Pages 117-126
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    4. Pre-Hospital Fluid Resuscitation in Civilian and Military Populations

      • Robert M. Van Haren, Chad M. Thorson, Col Lorne H. Blackbourne, Kenneth G. Proctor
      Pages 127-138
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  4. Current Issues of HBOCs and Regulatory Framework

    1. Front Matter

      Pages 139-139
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    2. NIH/FDA/DOD Interagency Working Group on Oxygen Therapeutics

      • Phyllis Mitchell, Richard Weiskopf, Warren M. Zapol
      Pages 141-147
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    3. Regulatory Framework for Hemoglobin-Based Oxygen Carrier Trials

      • Basil Golding
      Pages 149-156
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  5. Approaches to HBOCs

    1. Front Matter

      Pages 157-157
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    2. HBOCs from Chemical Modification of Hb

      • Ronald Kluger, Francine E. Lui
      Pages 159-183
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    3. Design of Nonhypertensive Conjugated Hemoglobins as Novel Resuscitation Fluids

      • Seetharama A. Acharya, Marcos Intaglietta, Amy G. Tsai, Fantao Meng
      Pages 185-234
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    4. Cellular-Type Hemoglobin-Based Oxygen Carriers to Mimic the Red Blood Cell Structure

      • Hiromi Sakai
      Pages 235-247
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    5. Recombinant Octameric Hemoglobins as Resuscitation Fluids in a Murine Model of Traumatic Brain Injury Plus Hemorrhagic Shock

      • Xianren Wu, Nancy T. Ho, Tong-Jian Shen, Vincent Vagni, David K. Shellington, Keri Janesko-Feldman et al.
      Pages 249-272
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    6. Liposome-Encapsulated Hemoglobin as an Artificial Oxygen Carrier: Technological Features, Manufacturing and Issues for Practical Application

      • Shinichi Kaneda, Takanobu Ishizuka, Hiroshi Goto, Hiroaki Kasukawa
      Pages 273-282
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    7. Zero-Link Hemoglobin (OxyVita®): Impact of Molecular Design Characteristics on Pre-clinical Studies

      • John P. Harrington, Hanna Wollocko
      Pages 283-297
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Editors and Affiliations

  • Brown University, Barrington, USA

    Hae Won Kim, A. Gerson Greenburg

Bibliographic Information

  • Book Title: Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics

  • Editors: Hae Won Kim, A. Gerson Greenburg

  • DOI: https://doi.org/10.1007/978-3-642-40717-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2013

  • Hardcover ISBN: 978-3-642-40716-1Published: 09 January 2014

  • Softcover ISBN: 978-3-662-50807-7Published: 03 September 2016

  • eBook ISBN: 978-3-642-40717-8Published: 18 December 2013

  • Edition Number: 1

  • Number of Pages: XXIII, 746

  • Number of Illustrations: 53 b/w illustrations, 77 illustrations in colour

  • Topics: Biomaterials, Molecular Medicine, Medicinal Chemistry, Hematology

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