Abstract
Non-alcoholic fatty liver disease (NAFLD) represents a spectrum of clinicopathological conditions in patients who do not consume excessive amounts of alcohol; these conditions are characterized by hepatic steatosis with or without other pathological changes observed in liver biopsy. The pathogenesis of NAFLD and its progressive form (non-alcoholic steatohepatitis [NASH]) appears to be multifactorial and is the subject of intense investigation. Increasing evidence indicates that the pathogenesis of NAFLD and NASH is hastened by a disturbance in adipokine production. Decreased serum adiponectin and increased tumor necrosis factor-α, which are characteristic of obesity, appear to contribute to the development and progression of NASH. The role of leptin in the pathogenesis of NASH remains controversial and the involvement of serum resistin is primarily documented only in animal models, which may or may not be applicable to the human form of NAFLD. Finally, other adipokines such as vaspin, visfatin, and apelin may play important roles in the pathogenesis of NASH and require further investigation.
Access provided by Autonomous University of Puebla. Download to read the full chapter text
Chapter PDF
Similar content being viewed by others
Key Words
References
Falck-Ytter Y, Younossi ZM, Marchesini G, et al. Semin Liver Dis 2001:;21:17–26.
Younossi ZM, Diehl AM, Ong JP. Hepatology 2002;35:746–752.
Matteoni CA, Younossi Z, Gramlich T, et al. Gastroenterology 1999;116:1413–1419.
Ong JP, Elariny H, Collantes R, et al. Obes Surg 2005;15:310–315.
Adams LA, Lymp JF, St Sauver J, et al. Gastroenterology 2005;129:113–121.
Caldwell SH, Oelsner DH, Iezzoni JC, et al. Hepatology 1999;29:664–669.
Bugianesi E, Leone N, Vanni E, et al. Gastroenterology 2002;123:134–140.
Gramlich T, Kleiner DE, McCullough AJ, et al. Hum Pathol 2004;35:196–199.
Saadeh S, Younossi ZM, Remer EM, et al. Gastroenterology 2002;123:745–750.
Angulo P, Lindor KD. Semin Liver Dis 2001;21:81–88.
Mulhall BP, Ong JP, Younossi ZM. J Gastroenterol Hepatol 2002;17:1136–1343.
McClain CJ, Mokshagundam SP, Barve SS, et al. Alcohol 2004;34:67–79.
Chitturi S, Farrell GC. Semin Liver Dis 2001;21:27–41.
Day CP, James OF. Gastroenterology 1998;114:842–845.
Koteish A, Diehl AM. Best Pract Res Clin Gastroenterol 2002;16: 679–690.
Lin HZ, Yang SQ, Chuckaree C, et al. Nat Med 2000;6:998–1003.
Pagano G, Pacini G, Musso G, et al. Hepatology 2002;35:367–372.
Liangpunsakul S, Chalasani N. Am J Med Sci 2005;329:111–116.
Choudhuri J, Sanyal AJ. Clin Liver Dis 2004;8:575–594.
Day CP. Best Pract Res Clin Gastroenterol 2002;16:663–678.
Fantuzzi G. J Allergy Clin Immunol 2005;115:911–919.
Skurk T, Herder C, Kraft I, et al. Endocrinology 2005;146:1006–1011.
Wellen KE, Hotamisligil GS. J Clin Invest 2003;112:1785–1788.
Fain JN, Madan AK, Hiler ML, et al. Endocrinology 2004;145:2273–2282.
Minn AH, Patterson NB, Pack S, et al. Biochem Biophys Res Commun 2003;310:641–645.
Li Z, Yang S, Lin H, et al. Hepatology 2003;37:343–350.
Faggioni R, Jones-Carson J, Reed DA, et al. Proc Natl Acad Sci USA 2000;97:2367–2372.
Yang RZ, Huang Q, Xu A, et al. Biochem Biophys Res Commun 2003;310:927–935.
Kushiyama A, Shojima N, Ogihara T, et al. J Biol Chem 2005;280:42,016–42,025.
Berg AH, Combs TP, Du X, et al. Nat Med 2001;7:947–953.
Yamauchi T, Kamon J, Waki H, et al. Nat Med 2001;7:941–946.
Xu A, Wang Y, Keshaw H, et al. J Clin Invest 2003;112:91–100.
Kamada Y, Tamura S, Kiso S, et al. Gastroenterology 2003;125:1796–1807.
Targher G, Bertolini L, Scala L, et al. Clin Endocrinol (Oxf) 2004;61:700–703.
Pagano C, Soardo G, Esposito W, et al. Eur J Endocrinol 2005;152:113–118.
Mendez-Sanchez N, Chavez-Tapia NC, Villa AR, et al. World J Gastroenterol 2005;11:1737–1741.
Zou CC, Liang L, Hong F, et al. Endocr J 2005;52:519–524.
Bugianesi E, Pagotto U, Manini R, et al. J Clin Endocrinol Metab 2005;90:3498–3504.
Hui JM, Hodge A, Farrell GC, et al. Hepatology 2004;40:46–54.
Musso G, Gambino R, Biroli G, et al. Am J Gastroenterol 2005;100:2438–2446.
Musso G, Gambino R, Durazzo M, et al. Hepatology 2005;42:1175–1183.
Comuzzie AG, Funahashi T, Sonnenberg G, et al. J Clin Endocrinol Metab 2001;86:4321–4325.
Menzaghi C, Ercolino T, Salvemini L, et al. Physiol Genomics 2004;19:170–174.
Zacharova J, Chiasson JL, Laakso M. STOP-NIDDM Study Group. Diabetes 2005;54:893–899.
Ukkola O, Santaniemi M, Rankinen T, et al. Ann Med 2005;37:141–150.
Kaser S, Moschen A, Cayon A, et al. Gut 2005;54:117–121.
Vuppalanchi R, Marri S, Kolwankar D, et al. J Clin Gastroenterol 2005;39:237–242.
Stefan N, Machicao F, Staiger H, et al. Diabetologia 2005;48:2282–2291.
Silswal N, Singh AK, Aruna B, et al. Biochem Biophys Res Commun 2005;334:1092–1101.
Bajaj M, Suraamornkul S, Hardies LJ. Int J Obes Relat Metab Disord 2004;28:783–789.
Uygun A, Kadayifci A, Yesilova Z, et al. Am J Gastroenterol 2000;95:3584–3589.
Yokoyama H, Hirose H, Ohgo H, et al. Alcohol Clin Exp Res 2004;28:159S–163S.
Kaplan LM. Gastroenterology1998;115:997–1001.
Piche T, Vandenbos F, Abakar-Mahamat A, et al. J Viral Hepat 2004;11:91–96.
Crespo J, Rivero M, Fabrega E, et al. Dig Dis Sci 2002;47:1604–1610.
Angulo P, Alba LM, Petrovic LM, et al. J Hepatol 2004;41:943–949.
Javor ED, Ghany MG, Cochran EK, et al. Hepatology 2005;41:753–760.
Feuerstein GZ, Liu T, Barone FC. Cerebrovasc Brain Metab Rev 1994;6:341–360.
Fain JN, Bahouth SW, Madan AK. Int J Obes Relat Metab Disord 2004;28:616–622.
Kugelmas M, Hill DB, Vivian B, et al. Hepatology 2003;38:413–419.
Crespo J, Cayon A, Fernandez-Gil P, et al. Hepatology 2001;34:1158–1163.
Adams LA, Zein CO, Angulo P, et al. Am J Gastroenterol 2004;99:2365–2368.
Satapathy SK, Garg S, Chauhan R, et al. Am J Gastroenterol 2004;99:1946–1952.
Fain JN, Bahouth SW, Madan AK. Biochem Pharmacol 2005;69:1315–1324.
Gao B. Alcohol 2004;34:59–65.
Mehta K, Van Thiel DH, Shah N, et al. Nutr Rev 2002;60:289–293.
Charlton M, Sreekumar R, Rasmussen D, et al. Hepatology 2002;35:898–904.
Ng TW, Watts GF, Farvid MS, et al. Diabetes 2005;54:795–802.
Yamauchi T, Kamon J, Minokoshi Y, et al. Nat Med 2002;8:1288–1295.
Combs TP, Pajvani UB, Berg AH, et al. Endocrinology 2004;145:367–383.
Unger RH, Zhou YT, Orci L. Proc Natl Acad Sci USA 1999;96:2327–2332.
Shimabukuro M, Koyama K, Chen G, et al. Proc Natl Acad Sci USA 1997;94:4637–4641.
Levin N, Nelson C, Gurney A, et al. Proc Natl Acad Sci USA 1996;93:1726–1730.
Cohen P, Friedman JM. J Nutr 2004;134:2455S–2463S.
Miyazaki M, Kim YC, Gray-Keller MP, et al. J Biol Chem 2000;275:30,132–30,138.
Lee Y, Yu X, Gonzales F, Mangelsdorf DJ, et al. Proc Natl Acad Sci USA 2002;99:11,848–11,853.
Minokoshi Y, Kim Y-B, Peroni OD, et al. Nature 2002;415:339–343.
VanPatten S, Ranginani N, Shefer S, et al. Am J Physiol Gastrointest Liver Physiol 2001;281:G393–G404.
Loria P, Lonardo A, Lombardini S, et al. J Gastroenterol Hepatol 2004;20:1176–1184.
Yang G, Ge H, Boucher A, et al. Mol Endocrinol 2004;18:1354–1362.
Sato N, Kobayashi K, Inoguchi T, et al. Endocrinology 2005; 146:273–279.
Chen CC, Li TC, Li CI, et al. Metabolism 2005;54:471–475.
Nachiappan V, Curtiss D, Corkey BE, et al. Shock 1994;1:123–129.
Glosli H, Gudbrandsen OA, Mullen AJ, et al. Biochim Biophys Acta 2005;1734:235–246.
Ruan H, Miles PD, Ladd CM, et al. Diabetes 2002;51:3176–3188.
Carling D. 150 Biochimie 2005;87:87–91.
Parulkar AA, Pendergrass ML, Granda-Ayala R, et al. Ann Intern Med 2001;134:61–71.
Watkins SM, Reifsnyder PR, Pan HJ, et al. J Lipid Res 2002;43:1809–1817.
Pocai A, Morgan K, Buettner C, et al. Diabetes 2005;54:3182–3189.
Hegyi K, Fulop K, Kovacs K, et al. Cell Biol Int 2004;28:159–169.
Lam NT, Lewis JT, Cheung AT, et al. Mol Endocrinol 2004;18:1333–1345.
Brabant G, Muller G, Horn R, et al. FASEB J 2005;19:1048–1050.
Banerjee RR, Rangwala SM, Shapiro JS, et al. Science 2004;303:1195–1198.
Gerber M, Boettner A, Seidel B, et al. J Clin Endocrinol Metab 2005;90:4503–4509.
Uysal KT, Wiesbrock SM, Marino MW, et al. Nature 1997;389:610–614.
Gupta D, Khandelwal RL. Biochim Biophys Acta 2004; 1671:51–58.
Berndt J, Kloting N, Kralisch S, et al. Diabetes 2005;54:2911–2916.
Fukuhara A, Matsuda M, Nishizawa M, et al. Science 2005;307:426–430.
Hida K, Wada J, Eguchi J, et al. Proc Natl Acad Sci USA 2005;102:10,610–10,615.
Kloting N, Berndt J, Kralisch S, et al. Biochem Biophys Res Commun. 2006;339:430–436.
Sorhede Winzell M, Magnusson C, Ahren B. Regul Pept 2005;131:12–17.
Boucher J, Masri B, Daviaud D, et al. Endocrinology 2005;146:1764–1771.
Heinonen MV, Purhonen AK, Miettinen P, et al. Regul Pept 2005;130:7–13.
Nakanishi S, Yamane K, Kamei N, et al. Metabolism 2005;54:194–199.
Soares AF, Guichardant M, Cozzone D, et al. Free Radic Biol Med 2005;38:882–889.
Hattori Y, Akimoto K, Gross SS, et al. Diabetologia 2005;48:1066–1074.
Balasubramaniyan V, Kalaivani Sailaja J, Nalini N. Pharmacol Res 2003;47:211–216.
Uzun H, Zengin K, Taskin M, et al. Obes Surg 2004;14:659–665.
Fruhbeck G. Diabetes 1999;48:903–908.
Forstermann U. Eur J Clin Pharmacol 2005;26:1–8.
Gonzalez FJ. Mutat Res 2005;569:101–110.
Chalasani N, Gorski JC, Asghar MS, et al. Hepatology 2003;37:544–550.
Kougias P, Chai H, Lin PH, et al. J Vasc Surg 2005;4:691–698.
Bo S, Gambino R, Pagani A, et al. Int J Obes (Lond) 2005;29:1315–1320.
Smith SR, Bai F, Charbonneau C, et al. Diabetes 2003;52:1611–1618.
Garcia-Ruiz C, Colell A, Mari M, et al. J Biol Chem 1997;272:11,369–11,377.
Arora AS, Jones BJ, Patel TC, et al. Hepatology 1997;25: 958–963.
Hao JH, Yu M, Liu FT, et al. Cancer Res 2004;64:3607–3616.
Uchino S, Yamaguchi Y, Furuhashi T, et al. J Surg Res 2004;120:73–82.
Lee FY, Li Y, Zhu H, et al. Hepatology 1999;29:677–687.
Baffy G. Front Biosci 2005;10:2082–2096.
Marra F, Aleffi S, Bertolani C, et al. Eur Rev Med Pharmacol Sci 2005;9:279–284.
Goetze S, Bungenstock A, Czupalla C, et al. Hypertension 2002;40:748–754.
Ding X, Saxena NK, Lin S, et al. Am J Pathol 2005;166:1655–1669.
Saxena NK, Ikeda K, Rockey DC, et al. Hepatology 2002;35:762–771.
Otte C, Otte JM, Strodthoff D, et al. Exp Clin Endocrinol Diabetes 2004;112:10–17.
Tomita K, Tamiya G, Ando S, et al. Gut 2005;55:415–424.
Kitamura K, Nakamoto Y, Akiyama M, et al. Lab Invest 2002;82:571–583.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Humana Press Inc., Totowa, NJ
About this chapter
Cite this chapter
Baranova, A., Younossi, Z.M. (2007). Adipokines in Non-Alcoholic Fatty Liver Disease. In: Fantuzzi, G., Mazzone, T. (eds) Adipose Tissue and Adipokines in Health and Disease. Nutrition and Health. Humana Press. https://doi.org/10.1007/978-1-59745-370-7_22
Download citation
DOI: https://doi.org/10.1007/978-1-59745-370-7_22
Publisher Name: Humana Press
Print ISBN: 978-1-58829-721-1
Online ISBN: 978-1-59745-370-7
eBook Packages: MedicineMedicine (R0)