Abstract
Protein secretion mediated by the secretory transport pathway is an important cellular process in eukaryotic cells. In the conventional secretory transport pathway, newly synthesized proteins pass through several endomembrane compartments en route to their specific destinations. Transport of secretory proteins between different compartments is shuttled by small, membrane-enclosed vesicles. To ensure the fidelity of transport, eukaryotic cells employ elaborate molecular machineries to accurately sort newly synthesized proteins into specific transport vesicles and precisely deliver these transport vesicles to distinct acceptor compartments. In this review, we summarize the molecular machineries that regulate each step of vesicular transport in the secretory transport pathway in yeast and animal cells.
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Acknowledgements
Y.G. acknowledges the support from the Hong Kong Research Grants Council Grants 26100315 and HKUST12/CRF/13G.
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Guo, Y., Yang, F., Tang, X. (2017). An Overview of Protein Secretion in Yeast and Animal Cells. In: Jiang, L. (eds) Plant Protein Secretion. Methods in Molecular Biology, vol 1662. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7262-3_1
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DOI: https://doi.org/10.1007/978-1-4939-7262-3_1
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