Abstract
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor of the basic helix-loop-helix family) It binds and is activated by a number of compounds, including polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene (B[a]P), which are generated during the combustion of fossil fuels and are present in tobacco smoke and smoked meats. The AHR also binds halogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzodioxin (TCDD), which is a contaminant formed during the manufacture of chlorophenols (for chemical structures see Fig. 1). Both these classes of AHR ligands are persistent environmental pollutants and cause a variety of toxic and carcinogenic effects that are mediated by the AHR.
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Ciolino, H.P., Yeh, G.C. (2001). The Effects of Resveratrol on CYP1A1 Expression and Aryl Hydrocarbon Receptor Function In Vitro . In: Nutrition and Cancer Prevention. Advances in Experimental Medicine and Biology, vol 492. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1283-7_14
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DOI: https://doi.org/10.1007/978-1-4615-1283-7_14
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