Collection
100 years of isocyanide-based multicomponent reactions
- Submission status
- Closed
2021 was the centennial of the discovery of Passerini reaction , the first isocyanide-based multicomponent reaction to be reported in the literature. Therefore 2021 can be considered the anniversary of all isocyanide-based multicomponent reactions (IMCRs). On this occasion, Molecular Diversity intends to publish a special issue dedicated to isocyanide-based multicomponent reactions and their applications.
Over the years this field has increasingly grown, expanding in various directions: a) new IMCRs have been discovered; b) new variants of the known IMCRs, by changing one of the components, have been developed; c) new scaffolds have been obtained by post-MCR transformations; d) new conditions (unusual solvents, catalysts) have been explored explored; e) new solutions of stereochemical problems have been proposed. Last but not least, IMCR are more and more applied in various fields, from the most traditional one (drug discovery), to others that have become increasingly important in recent years, such as: polymer chemistry, material synthesis, target-oriented synthesis of APIs or natural substances.
Editors
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Chiara Lambruschini, PhD, University of Genoa, Italy
Chiara Lambruschini is an Assistant Professor in the Department of Chemistry and Industrial Chemistry at the University of Genoa, Italy
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Luca Banfi, MS, University of Genoa, Italy
Luca Banfi is a Professor at the University of Genoa, Italy. He is the director of the Department of Chemistry and Industrial Chemistry
Articles (13 in this collection)
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Ethyl 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate in the smiles rearrangement reaction: straightforward synthesis of amino acid derived quinolin-2(1H)-one enamines
Authors (first, second and last of 6)
- Sirous Haghipour
- Morteza Mehrdad
- Mohammad Mahdavi
- Content type: Short Communication
- Published: 08 February 2023
- Pages: 2345 - 2352
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Curation and cheminformatics analysis of a Ugi-reaction derived library (URDL) of synthetically tractable small molecules for virtual screening application
Authors (first, second and last of 5)
- Mukesh Tandi
- Nancy Tripathi
- Sandeep Sundriyal
- Content type: Original Article
- Published: 27 December 2022
- Pages: 37 - 50
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First-row transition metal for isocyanide-involving multicomponent reactions (IMCR)
Authors
- Mayur I. Morja
- Riddhi B. Moradiya
- Kishor H. Chikhalia
- Content type: Comprehensive Review
- Published: 20 December 2022
- Pages: 2895 - 2934
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Silver acetate-catalyzed synthesis of cyclic sulfonyl guanidine with exocyclic double bond
Authors
- Dikshita Goswami
- Debashish Mishra
- Prodeep Phukan
- Content type: Original Article
- Published: 15 November 2022
- Pages: 2545 - 2553
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Enantiopure β-isocyano-boronic esters: synthesis and exploitation in isocyanide-based multicomponent reactions
Authors (first, second and last of 5)
- Marco Manenti
- Simone Gusmini
- Alessandra Silvani
- Content type: Original Article
- Open Access
- Published: 19 October 2022
- Pages: 2161 - 2168
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Application of the Ugi reaction for preparation of submicron capsules based on sugar beet pectin
Authors (first, second and last of 5)
- Rita S. Alqubelat
- Manar M. Obiedallah
- Maxim A. Mironov
- Content type: Original Article
- Published: 13 September 2022
- Pages: 1957 - 1969
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New oxacycles on the block: benzodioxepinones via a Passerini reaction
Authors (first, second and last of 4)
- Michael Fragkiadakis
- Marios Zingiridis
- Constantinos G. Neochoritis
- Content type: Original Article
- Published: 28 July 2022
- Pages: 29 - 35
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A synthesis of functionalized 3-amino-1,2,4-triazoles from nitrile imines and guanidine derivatives
Authors
- Issa Yavari
- Zohreh Taheri
- Sara Sheikhi
- Content type: Original Article
- Published: 17 July 2022
- Pages: 11 - 18
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A facile one-pot synthesis of new functionalized pyrazolone-1,4-dithiafulvene hybrids
Authors
- Jaber Salehzadeh
- Farough Nasiri
- Content type: Original Article
- Published: 28 June 2022
- Pages: 19 - 28
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Design of a new method for the synthesis of novel 2-aryl/alkyl-3H-indol-3-ones
Authors
- Ali Akbari
- Neda Seyedi
- Muhammad Saleh Faryabi
- Content type: Original Article
- Published: 17 June 2022
- Pages: 3 - 9
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Synthesis of fused polycyclic β-carboline derivatives using Ugi-4CR followed by cascade cyclization
Authors (first, second and last of 6)
- Vipin Kumar
- Anjali Saxena
- Biswajit Saha
- Content type: Short Communication
- Published: 02 June 2022
- Pages: 951 - 957
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Domino synthesis of 5-aminoimidazoles from Strecker multicomponent adducts via ytterbium-promoted isocyanide insertion/5-exo-dig cyclization
Authors (first, second and last of 8)
- Rolando Cannalire
- Camilla Russo
- Mariateresa Giustiniano
- Content type: Short Communication
- Published: 13 April 2022
- Pages: 511 - 515