Abstract
In 1930, Moore discovered that β-carotene (3) could be converted in vivo into vitamin A [1]. Since then, the vitamin A values of β-carotene and other provitamin A carotenoids, particularly α-carotene (7) and β-cryptoxanthin (55), have been investigated by various techniques. As discussed in Chapter 9, vitamin A nutrition is of worldwide interest; deficiency of the vitamin remains a problem in developing countries, affecting 75 to 140 million children [2]. Deficiency of vitamin A (VAD) can result in visual malfunction such as night blindness and xerophthalmia [3], and can impair immune function [4], resulting in an increased incidence and/or severity of respiratory infections, gastrointestinal infections [5], and measles [6]. Vitamin A levels in HIV-positive children are lower than those in HIV-negative children [7].
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References
T. Moore, Biochem. J., 24, 696 (1930).
United Nations Administrative Committee on Coordination Sub-Committee on Nutrition (ACC/SCN), The 4th Report on the World Nutrition Situation — Nutrition Throughout the Life Cycle, 2000. (http://www.unsystem.org/SCN/archives/rwn.s04/begin.htm#Contents)
A. Sommer, Nutritional Blindness: Xerophthalmia and Keratomalacia, Oxford University Press, New York (1982).
A. Ross and C. Stephensen, FASEB J., 10, 979 (1996).
N. Usha, A. Sankaranarayanan, B. Walia and N. Ganguly, J. Pediatr Gastroenterol. Nutr., 13, 168 (1991).
A. Sommer and K. P. West Jr., Vitamin A Deficiency. Health, Survival, and Vision. Oxford University Press, New York (1996).
J. Jason, L. K. Archibald, O. C. Nwanyanwu, A. L. Sowell, L. Anne, I. Buchanan, J. Larned, M. Bell, P. N. Kazembe, H. Dobbie and W. R. Jarvis, Clin. Diagnostic Lab. Immunol., 9, 616 (2002).
K. Ge, F. Zhai and H. Ye, Acta Nutr. Sinica, 17, 123 (1995).
J. Olson, Am. J. Clin. Nutr., 45, 704 (1987).
A. Sommer, I. Tarwotjo, E. Djunaedi, K. P. West Jr, A. A. Loeden, R. Tilden and L. Mele, Lancet, 1, 1169 (1986).
L. Rahmathullah, B. Underwood, R. Thulasiraj, R. C. Milton, K. Ramaswamy, R. Rahmathullah and G. Babu, New Eng. J. Med., 323, 929 (1990).
K. P. West Jr., R. Pokhrel, J. Katz, S. C. LeClerq, S. K. Khatry, S. R. Shrestha, E. K. Pradhan, J. M. Tielsch, M. R. Pandey and A. Sommer, Lancet, 338, 67 (1991).
K. P. West Jr., J. Katz, S. K. Khatry, S. C. LeClerq, E. K. Pradhan, S. R. Shrestha, P. B. Connor, S. M. Dai, P. Christian, R. P. Pokhrel and A. Sommer, on behalf of ia]the NNPS-2 Study Group, Br. Med. J., 318, 570(1999).
E. Villamow and W. W. Fawzi, J. Infect. Disease, 182 (Suppl. 1), S122 (2000).
B. A. Underwood and P. Arthur, FASEB J., 10, 1040(1996).
S. de Pee, C. E. West, Muhilal, D. Karyadi and J. G. A. J. Hautvast, Lancet, 346, 75 (1995).
J. Bulux, J. D. Serrano, A. Giuliano, R. Perez, C. Y. Lopez, C. Rivera, N. W. Solomons and L. M. Canfield, Am. J. Clin. Nutr., 59, 1369 (1994).
G. van Poppel and R. Goldbohm, Am. J. Clin. Nutr., 62, 1393S (1995).
J. M. Gaziano and C. H. Hennekens, Ann. NY Acad. Sci., 691, 148 (1993).
J. Goldberg, G. Flowerdew, E. Smith, J. Brody and M. Tso, Am. J. Epidemiol., 128, 700 (1988).
J. M. Seddon, U. A. Ajani, R. D. Sperduto, R. Hiller, N. Blair, T. C. Burton, M. D. Farber, E. S. Gragoudas, J. Haller and D. T. Miller, JAMA, 727, 1413 (1994).
S. E. Hankinson, M. J. Stampfer, J. M. Seddon, G. A. Colditz, B. Rosner, F. E. Speizer and W. C. Willett, Br. Med. J., 305, 335 (1992).
P. F. Jacques, L. T. Chylack, R. B. McGandy and S. C. Hartz, Arch. Ophthalmol., 106, 337 (1988).
C. H. Hennekens, U. E. Birring and R. Peto, New Engl. J. Med., 330, 1080 (1994).
ia]The α-Tocopherol, β-Carotene Cancer Prevention Study Group, New Engl. J. Med., 330, 1029 (1994).
G. S. Omenn, G. Goodman, M. D. Thongquist, J. Balines, M. R. Cullen, A. Glass, J. P. Keogh, F. L. Meyskens, B. Valanis, J. H. Williams, S. Barnhart and S. Hammar, New Engl. J. Med., 334, 1150 (1996).
J. A. Olson and O. Hayaishi, Proc. Natl. Acad. Sci. USA, 54, 1364 (1965).
D. S. Goodman, H. S. Huang and T. Shiratori, J. Biol. Chem., 241, 1929 (1966).
J. Glover and E. R. Redfearn, Biochem. J., 58, 15 (1954).
J. Ganguly and P. S. Sastry, Wld. Rev. Nutr. Diet., 45, 198 (1985).
X. D. Wang, G. Tang, J. G. Fox, N.I. Krinsky and R. M. Russell, Arch. Biochem. Biophys., 285, 8 (1991).
G. Tang, X. D. Wang, R. M. Russell and N. I. Krinsky, Biochemistry, 30, 9829 (1991).
K.-J. Yem, A. L. A. Ferreira, D. Smith, N. I. Krinsky and R. M. Russell, Free Radic. Biol. Med., 29, 105(2000).
J. von Lintig and K. Vogt, J. Biol. Chem., 275, 11915 (2000).
C. Kiefer, S. Hessel, J. M. Lampert, K. Vogt, M. O. Lederer, D. E. Breithaupt and J. von Lintig, J. Biol. Chem., 276, 14110 (2001).
A. Lindqvist, Y.-K. He and S. Anderson, J. Histochem. Cytochem., 53, 1403 (2005).
D. S. Goodman, R. Blomstrand, B. Werner, H. S. Huang and T. Shiratori, J. Clin. Invest., 45, 1615 (1966).
R. Blomstrand and B. Werner, Scand. J. Clin. Lab. Invest., 19, 339 (1967).
R. S. Dueker, Y. Lin, A. B. Buchholz, P. D. Schneider, M. W. Lamé, H. J. Segall, J. S. Vogel and A. J. Clifford, J. Lipid Res., 41, 1790 (2000).
S. L. Lemke, S. R. Dueker, J. R. Follett, Y. Lin, C. Carkeet, B. A. Buchholz, J. S. Vogel and A. J. Clifford, J. Lipid Res., 44, 1591 (2003).
E. M. Hume and H. A. Krebs, Medical Research Council Special Report Series, No. 264, His Majesty’s Stationery Office, London (1949).
H. E. Sauberlich, R. E. Hodges, D. L. Wallace, H. Kolder, J. E. Canham, J. Hood, N. Racia and L. K. Lowry, Vit. Horm., 32, 251 (1974).
L. E. Booher, E. C. Calliston and E. M. Hewston, J. Nutr., 17, 317 (1939).
K. H. Wagner, Ztschrf. Physiol. Chem., 264, 153 (1940).
J. C. Bauernfeind, J. Agr. Food Chem., 20, 456 (1972).
FAO/WHO, Report of a Joint Food and Agriculture Organization/World Health Organization Experts Committee. FAO Nutrition Meeting Report Series No. 41. WHO Technical Report Series No. 362. World Health Organization, Geneva (1967).
NRC (National Research Council), Recommended Dietary Allowances, 9th Revised Edition, Report of the Committee on Dietary Allowances, Food and Nutrition Board, Division of Biological Sciences, Assembly of Life Sciences, National Academy of Sciences, Washington, D.C. (1980).
E. D. Brown, M. S. Micozzi, N. E. Craft, J. G. Bieri, G. Beecher, B. K. Edwards, A. Rose, P. R. Taylor and J. C. Smith Jr., Am. J. Clin. Nutr., 49, 1258 (1989).
E. D. Brown, A. Rose, N. Craft, K. E. Seidel and J. C. Smith, Clin. Chem., 35, 310 (1989).
E. J. Johnson and R. M. Russell, Am. J. Clin. Nutr., 56, 128 (1992).
J. Bulux, J. Q. de Serrano, R. Perez, C. Rivera and N. W. Solomons, Am. J. Clin. Nutr., 49, 173 (1998).
S. de Pee, C. E. West, D. Permaesih, S. Martuti, K. Muhilal and G. Hautvast, Am. J. Clin. Nutr., 68, 1058 (1998).
N. C. Khan, C. E. West, S. de Pee. D. Bosch, H. D. Pluong, P. J. M. Hulshof, H. H. Khoi, H. Verhoef and J. G. A. J. Hautvast, Am. J. Clin. Nutr., 85, 1112 (2007).
G. Tang, X. Gu, Q. Xu, X. Zhao, J. Qin, C. Fjeld, G. G. Dolnikowski, R. M. Russell and S. Yin, Am. J. Clin. Nutr., 70, 1069(1999).
M. J. Haskell, K. M. Jamil, F. Hassan, J. M. Peerson, M. I. Hossain, G. J. Fuchs and K. H. Brown, Am. J. Clin. Nutr., 80, 705 (2004).
J. D. Ribaya-Mercado, C. C. Maramag, L. W. Tengco, G. G. Dolnikowski, J. B. Blumberg and F. S. Solon, Am. J. Clin. Nutr., 85, 1041 (2007).
T. van Vliet, W. H. P. Schreurs and H. van den, Berg Am. J. Clin. Nutr., 62, 110 (1995).
M. E. O’Neill and D. I. Thurnham, Br. J. Nutr., 79, 149(1998).
H. van den Berg and T. van Vliet, Am. J. Clin. Nutr., 68, 82 (1998).
R. S. Parker, J. E. Swanson, C.-S. You, A. J. Edwards and T. Huang, Proc. Nutr. Soc., 58, 1 (1999).
R. S. Parker, J. E. Swanson, B. Marmor, K. J. Goodman, A. B. Spielman, J. T. Brenna, S. M. Viereck and W. K. Canfield, in Carotenoids in Human Health, (ed. L. M.. Canfield, N. I. Krinsky and J. A Olson), p. 86, New York Academy of Sciences, New York, NY (1993).
S. R. Dueker, A. D. Jones, G. M. Smith and A. J. Clifford, Anal. Chem., 66, 4177 (1994).
J. Novotny, S. R. Dueker, L. Zech and A. J. Clifford, J. Lipid Res., 36, 1825 (1995).
Y. Lin, S. R. Dueker, B. J. Burri, T. R. Reidlinger and A. J. Clifford, Am J. Clin. Nutr., 71, 1545 (2000).
R. B. van Breemen, Anal. Chem., 67, 2004 (1995).
M. van Lieshout, C. E. West, D. Permaesih, Y. Wang, X. Xu, R. B. van Breemen, A. F. L. Creemers, M. A. Verhoeven and J. Lugtenburg, Am. J. Clin. Nutr., 73, 949 (2001).
G. Tang, B. Andrien, G. Dolnikowski and R. M. Russell, Meth. Enzymol., 282, 140 (1997).
G. Tang, J. Qin, G. G. Dolnikowski and R. M. Russell, Eur. J. Nutr., 39, 7 (2000).
G. Tang, J. Qin and G. G. Dolnikowski, J. Nutr. Biochem., 9, 408 (1998).
G. Tang, J. Qin, G. G. Dolnikowski and R. M. Russell, Am. J. Clin. Nutr., 78, 259 (2003).
Z. Wang, X. Zhao, S. Yin, R. M. Russell and G. Tang, Br. J. Nutr., 91, 121 (2004).
J. Sabrina, L. Hickenbottom, L. Shawna, S. R. Dueker, Y. Lin, J. R. Follett, C. Carkeet, B. A. Buchholz, J. S. Vogel and A. J. Clifford, Eur. J. Nutr., 41, 141 (2002).
M. Grusak, J. Nutr. Biochem., 8, 164 (1997).
G. Tang, J. Qin, G. G. Dolnikowski, R. M. Russell and M. G. Grusak, Am. J. Clin. Nutr., 82, 821 (2005).
J. Wang, Y. Wang, Z. Wang, L. Li, J. Qin, W. Lai, Y. Fu, P. M. Suter, R. M. Russell, M. A. Grusak, G. Tang, and S. Yin. Am. J. Clin. Nutr., 87, 1730 (2008).
J. A. Novotny, A. C. Kurilich, S. J. Britz and B. A. Clevidence, Lipid Res., 46, 1896 (2005).
L. Villard and C. Bates, Br. J. Nutr., 56, 115 (1986).
T. van Vliet, M. F. van Vlissingen, F. van Schaik and H. van den Berg, J. Nutr., 126, 499 (1996).
V. R. Lala and V. Ready, Am. J. Clin. Nutr., 23, 110 (1970).
F. McEvoy and W. Lynn, J. Biol. Chem., 248, 4568 (1973).
T. W. Goodwin, The Biochemistry of the Carotenoids. Vol. 1. Plants. Chapman and Hall, London and New York (1980).
X. Ye, S. Al-Babili, A. Kloti, J. Zhang, P. Lucca, P. Beyer and I. Potrykus, Science, 287, 303 (2000).
J. M. J. Castenmiller, C. E. West, J. B. H. Linssen, K. H. van het Hof and A. G. J. Voragen, J. Nutr., 129, 349(1999).
A. J. Edwards, C. H. Nguyen, C.-S. You, J. E. Swanson, C. Emenhiser and R. S. Parker, J. Nutr., 132, 159 (2002).
D. Kostic, W. S. White and J. A. Olson, Am. J. Clin. Nutr., 62, 604 (1995).
S. G. Parvin and B. Sivakuma, J Nutr., 130, 573, (2000).
F. Jalal, M. C. Nesheim, Z. Agus, D. Sanjur and J. P. Habicht, Am. J. Clin. Nut., 68, 623 (1998).
D. M. Deming, A. C. Boileau, C. M. Lee and J. W. Erdman Jr., J. Nutr., 130, 2789 (2000).
S. A. Tanumihardjo and J. A. Howe, J. Nutr., 135, 2622 (2005).
D. M. Deming, D. H. Baker and J. W. Erdman Jr., J. Nutr., 132, 2709 (2002).
D. M. Deming, S. R. Teixeira and J. W. Erdman Jr., J. Nutr., 132, 2700 (2002).
P. Chambon, FASEB J., 10, 940 (1996).
X. D. Wang, R. M. Russell, R. P. Marini, G. Tang, G. G. Dolnikowski, J. G. Fox, and N. I. Krinsky, Biochim. Biophys. Acta, 1167, 159 (1993).
X. Hebuterne, X. D. Wang, D. E. H. Smith, G. Tang and R. M. Russell, J. LipidRes., 37, 482 (1996).
X.-D Wang, N. I. Krinsky, G. Tang and R. M. Russell, Arch. Biochem. Biophys., 293, 298 (1992).
Y. Folman, R. M. Russell, G. Tang and G. Wolf, Br. J. Nutr., 62, 195 (1989).
R. B. Martucci, A. L. Ziulkoski, V. A. Fortuna, R. M. Guaragna, F. C. R. Guma, L. C. Trugo and R. Borojevic, J. Cell. Biochem., 92, 414 (2004).
J. L. Napoli and K. R. Race, J. Biol. Chem., 263, 17372 (1988).
C. C. Ho, F. F. de Moura, S.-H. Kim and A. J. Clifford, Am. J. Clin. Nutr., 85, 770 (2007).
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Tang, G., Russell, R.M. (2009). Carotenoids as Provitamin A. In: Britton, G., Pfander, H., Liaaen-Jensen, S. (eds) Carotenoids. Carotenoids, vol 5. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-7501-0_8
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