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Das Konzept der Pollen-Panallergene: Profiline und Polcalcine

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Molekulare Allergiediagnostik

Zusammenfassung

Profiline und Polcalcine zählen wegen ihres ubiquitären Vorkommens und der hohen Kreuzreaktivität zur Gruppe der Panallergene. Bis heute wurden 44 Profilin- und 15 Polcalcinallergene identifiziert. Profiline sind Aktin-bindende Proteine – was Funktionen in einer ganzen Reihe essenzieller, zellulärer Prozesse erklärt – und konnten in diversen Nahrungsmitteln sowie in Pollen und Latex nachgewiesen werden. Die Funktion der Polcalcine beinhaltet die Regulation des Ca++-Haushalts, daher rührt auch ihre Bezeichnung. Ihr Vorkommen ist auf Pollen beschränkt. Reaktionen auf Panallergene verursachen im Hauttest meist ein Bild multipler Sensibilisierungen, wobei spezifisches IgE gegenüber einer Reihe biologisch nicht verwandter Allergenquellen messbar ist. Häufig sind diese Sensibilisierungen oder Kreuzreaktionen jedoch irrelevant, nur in seltenen Fällen stellen Panallergene klinisch relevante Majorallergene dar.

Der Beitrag basiert auf einer Publikation der Autoren, die 2012 im Allergo Journal erschienen ist (Hauser M, Wallner M, Ferreira F, Mahler V, Kleine-Tebbe J: Das Konzept der Pollen-Panallergene: Profiline und Polcalcine. Allergo J 2012; 21: 291–293) und nun als Buchkapitel aktualisiert und erweitert wurde.

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Literatur

  • Alvarado MI, Jimeno L, De La Torre F, Boissy P, Rivas B, Lazaro M, Barber D (2014) Profilin as a severe food allergen in allergic patients overexposed to grass pollen. Allergy 69:1610–1616

    Article  CAS  PubMed  Google Scholar 

  • Assarehzadegan MA, Amini A, Sankian M, Tehrani M, Jabbari F, Varasteh A (2010) Sal k 4, a new allergen of Salsola kali, is profilin: a predictive value of conserved conformational regions in cross-reactivity with other plant-derived profilins. Biosci Biotechnol Biochem 74:1441–1446

    Article  CAS  PubMed  Google Scholar 

  • Asturias JA, Ibarrola I, Fernandez J, Arilla MC, Gonzalez-Rioja R, Martinez A (2005) Pho d 2, a major allergen from date palm pollen, is a profilin: cloning, sequencing, and immunoglobulin E cross-reactivity with other profilins. Clin Exp Allergy 35:374–381

    Article  CAS  PubMed  Google Scholar 

  • Balla T (2013) Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev 93:1019–1137

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Ballmer-Weber BK, Hoffmann A, Wuthrich B, Luttkopf D, Pompei C, Wangorsch A, Kastner M, Vieths S (2002) Influence of food processing on the allergenicity of celery: DBPCFC with celery spice and cooked celery in patients with celery allergy. Allergy 57:228–235

    Article  CAS  PubMed  Google Scholar 

  • Barber D, de la Torre F, Feo F, Florido F, Guardia P, Moreno C, Quiralte J, Lombardero M, Villalba M, Salcedo G, Rodriguez R (2008) Understanding patient sensitization profiles in complex pollen areas: a molecular epidemiological study. Allergy 63:1550–1558

    Article  CAS  PubMed  Google Scholar 

  • Barderas R, Villalba M, Pascual CY, Batanero E, Rodriguez R (2004) Profilin (Che a 2) and polcalcin (Che a 3) are relevant allergens of Chenopodium album pollen: isolation, amino acid sequences, and immunologic properties. J Allergy Clin Immunol 113:1192–1198

    Article  CAS  PubMed  Google Scholar 

  • Casquete-Roman E, Rosado-Gil T, Postigo I, Guisantes JA, Fernandez M, Torres HE, Martinez-Quesada J (2012) Profilin cross-reactive panallergen causes latex sensitization in the pediatric population allergic to pollen. Ann Allergy Asthma Immunol 109:215–219

    Article  CAS  PubMed  Google Scholar 

  • Focke M, Marth K, Valenta R (2009) Molecular composition and biological activity of commercial birch pollen allergen extracts. Eur J Clin Invest 39:429–436

    Article  CAS  PubMed  Google Scholar 

  • Hatzler L, Panetta V, Lau S, Wagner P, Bergmann RL, Illi S, Bergmann KE, Keil T, Hofmaier S, Rohrbach A, Bauer CP, Hoffman U, Forster J, Zepp F, Schuster A, Wahn U, Matricardi PM (2012) Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever. J Allergy Clin Immunol 130:894–901 (e5)

    Article  CAS  PubMed  Google Scholar 

  • Hauser M, Roulias A, Ferreira F, Egger M (2010) Panallergens and their impact on the allergic patient. Allergy Asthma Clin Immunol 6:1

    Article  PubMed Central  PubMed  Google Scholar 

  • Hauser M, Wallner M, Ferreira F, Mahler V, Kleine-Tebbe J (2012) Das Konzept der Pollen-Panallergene: Profiline und Polcalcine. Allergo J 21:291–293

    Article  Google Scholar 

  • Kleine-Tebbe J, Balmer-Weber B, Breiteneder H, Vieths S (2010) Bet v 1 und Homologe – Verursacher der Baumpollenallergie und birkenpollenassoziierter Kreuzreaktionen. Allergo J 19:462–464

    Google Scholar 

  • Kühn A, Radauer C, Swoboda I, Kleine-Tebbe J (2012) Molekulare Diagnostik der Fischallergie: Parvalbumine und andere Allergene. Allergo J 21:16–18

    Article  Google Scholar 

  • Le LQ, Mahler V, Lorenz Y, Scheurer S, Biemelt S, Vieths S, Sonnewald U (2006) Reduced allergenicity of tomato fruits harvested from Lyc e 1-silenced transgenic tomato plants. J Allergy Clin Immunol 1180:1176–1183

    Article  Google Scholar 

  • Ma Y, Zuidmeer L, Bohle B, Bolhaar ST, Gadermaier G, Gonzalez-Mancebo E, Fernandez-Rivas M, Knulst AC, Himly M, Asero R, Ebner C, van Ree R, Ferreira F, Breiteneder H, Hoffmann-Sommergruber K (2006) Characterization of recombinant Mal d 4 and its application for component-resolved diagnosis of apple allergy. Clin Exp Allergy 36:1087–1096

    Article  CAS  PubMed  Google Scholar 

  • Magler I, Nuss D, Hauser M, Ferreira F, Brandstetter H (2010) Molecular metamorphosis in polcalcin allergens by EF-hand rearrangements and domain swapping. FEBS J 277:2598–2610

    Article  CAS  PubMed  Google Scholar 

  • Mirza O, Henriksen A, Ipsen H, Larsen JN, Wissenbach M, Spangfort MD, Gajhede M (2000) Dominant epitopes and allergic cross-reactivity: complex formation between a Fab fragment of a monoclonal murine IgG antibody and the major allergen from birch pollen Bet v 1. J Immunol 165:331–338

    Article  CAS  PubMed  Google Scholar 

  • Nouri HR, Sankian M, Vahedi F, Afsharzadeh D, Rouzbeh L, Moghadam M, Varasteh A (2012) Diagnosis of Chenopodium album allergy with a cocktail of recombinant allergens as a tool for component-resolved diagnosis. Mol Biol Rep 39:3169–3178

    Article  CAS  PubMed  Google Scholar 

  • Pfaar O, Bachert C, Bufe A, Buhl R, Ebner C, Eng P, Friedrichs F, Fuchs T, Hamelmann E, Hartwig-Bade D, Hering T, Huttegger I, Jung K, Klimek L, Kopp MV, Merk H, Rabe U, Saloga J, Schmid-Grendelmeier P, Schuster A, Schwerk N, Sitter H, Umpfenbach U, Wedi B, Wöhrl S, Worm M, Kleine-Tebbe J (2014) Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases – S2k Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Society for Pediatric Allergy and Environmental Medicine (GPA), the Medical Association of German Allergologists (AeDA), the Austrian Society for Allergy and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Dermatology (DDG), the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Pneumology (GPP), the German Respiratory Society (DGP), the German Association of ENT Surgeons (BV-HNO), the Professional Federation of Paediatricians and Youth Doctors (BVKJ), the Federal Association of Pulmonologists (BDP) and the German Dermatologists Association (BVDD). Allergo J Int 23:282–319. doi:10.1007/s40629-014-0032-2

    Article  PubMed Central  PubMed  Google Scholar 

  • Raulf-Heimsoth M, Rihs HP (2011) Latexallergene: Sensibilisierungsquellen und Einzelallergenprofile erkennen. Allergo J 20:241–243

    Google Scholar 

  • van Ree R, Fernandez-Rivas M, Cuevas M, van Wijngaarden M, Aalberse RC (1995) Pollen-related allergy to peach and apple: an important role for profilin. J Allergy Clin Immunol 95:726–734

    Article  PubMed  Google Scholar 

  • Rodriguez-Perez R, Crespo JF, Rodriguez J, Salcedo G (2003) Profilin is a relevant melon allergen susceptible to pepsin digestion in patients with oral allergy syndrome. J Allergy Clin Immunol 111:634–639

    Article  CAS  PubMed  Google Scholar 

  • Santos A, Van Ree R (2011) Profilins: mimickers of allergy or relevant allergens? Int Arch Allergy Immunol 155:191–204

    Article  CAS  PubMed  Google Scholar 

  • Schmid-Grendelmeier P (2010) Recombinant allergens. For routine use or still only science? Hautarzt 61:946–953

    Article  CAS  PubMed  Google Scholar 

  • Tanaka M, Shibata H (1995) Poly(L-proline)-binding proteins from chick embryos are a profilin and a profilactin. Eur J Biochem 151:291–297

    Article  Google Scholar 

  • Tehrani M, Sankian M, Assarehzadegan MA, Falak R, Noorbakhsh R, Moghadam M, Jabbari F, Varasteh A (2011) Identification of a new allergen from Amaranthus retroflexus pollen, Ama r 2. Allergol Int 60:309–316

    Article  CAS  PubMed  Google Scholar 

  • Tinghino R, Twardosz A, Barletta B, Puggioni EM, Iacovacci P, Butteroni C, Afferni C, Mari A, Hayek B, Di Felice G, Focke M, Westritschnig K, Valenta R, Pini C (2002) Molecular, structural, and immunologic relationships between different families of recombinant calcium-binding pollen allergens. J Allergy Clin Immunol 109:314–320

    Article  CAS  PubMed  Google Scholar 

  • Valenta R, Duchene M, Pettenburger K, Sillaber C, Valent P, Bettelheim P, Breitenbach M, Rumpold H, Kraft D, Scheiner O (1991) Identification of profilin as a novel pollen allergen; IgE autoreactivity in sensitized individuals. Science 253:557–560

    Article  CAS  PubMed  Google Scholar 

  • Vallverdu A, Garcia-Ortega P, Martinez J, Martinez A, Esteban MI, de Molina M, Fernandez-Tavora L, Fernandez J, Bartolome B, Palacios R (1997) Mercurialis annua: characterization of main allergens and cross-reactivity with other species. Int Arch Allergy Immunol 112:356–364

    Article  CAS  PubMed  Google Scholar 

  • Verdino P, Barderas R, Villalba M, Westritschnig K, Valenta R, Rodriguez R, Keller W (2008) Three-dimensional structure of the cross-reactive pollen allergen Che a 3: visualizing cross-reactivity on the molecular surfaces of weed, grass, and tree pollen allergens. J Immunol 180:2313–2321

    Article  CAS  PubMed  Google Scholar 

  • Witke W (2004) The role of profilin complexes in cell motility and other cellular processes. Trends Cell Biol 14:461–469

    Article  CAS  PubMed  Google Scholar 

  • Wopfner N, Dissertori O, Ferreira F, Lackner P (2007) Calcium-binding proteins and their role in allergic diseases. Immunol Allergy Clin North Am 27:29–44

    Article  PubMed  Google Scholar 

  • Wopfner N, Gruber P, Wallner M, Briza P, Ebner C, Mari A, Richter K, Vogel L, Ferreira F (2008) Molecular and immunological characterization of novel weed pollen pan-allergens. Allergy 63:872–881

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Fachbereich Molekulare Biologie, Universität Salzburg, Hellbrunnerstraße 34, 5020, Salzburg, Österreich

    Dr. rer. nat. Michael Wallner, Univ. Prof. Dr. rer. nat. Fatima Ferreira-Briza, Heidi Hofer & Dr. rer. nat. Michael Hauser

  2. Praxis Hanf, Ackermann u. Kleine-Tebbe, Allergie- und Asthma-Zentrum Westend, Spandauer Damm 130, Haus 9, 14050, Berlin, Deutschland

    PD Dr. med. Jörg Kleine-Tebbe

  3. Allergieabteilung der Hautklinik, Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Deutschland

    Prof. Dr. med. Vera Mahler

Authors
  1. Dr. rer. nat. Michael Wallner
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  2. Univ. Prof. Dr. rer. nat. Fatima Ferreira-Briza
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  3. Heidi Hofer
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  4. Dr. rer. nat. Michael Hauser
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  5. Prof. Dr. med. Vera Mahler
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  6. PD Dr. med. Jörg Kleine-Tebbe
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Editors and Affiliations

  1. Allergie- und Asthma-Zentrum Westend, Praxis Hanf, Ackermann und Kleine-Tebbe, Berlin, Germany

    Jörg Kleine-Tebbe

  2. Universitätsklinikum Gießen und Marburg, Klinik für Dermatologie und Allergologie, Freiburg im Breisgau, Germany

    Thilo Jakob

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Wallner, M., Ferreira-Briza, F., Hofer, H., Hauser, M., Mahler, V., Kleine-Tebbe, J. (2015). Das Konzept der Pollen-Panallergene: Profiline und Polcalcine. In: Kleine-Tebbe, J., Jakob, T. (eds) Molekulare Allergiediagnostik. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45221-9_3

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  • DOI: https://doi.org/10.1007/978-3-662-45221-9_3

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