Abstract
“The obstetrician bids, and the uterus contracts” was the title of Chassar Moir’s Sandoz Foundation lecture given in 1964 (Moir, 1964). With this categorical statement he pointed to the great reliability of some drugs, and in particular of ergot, in causing the uterus to contract, thereby diminishing or preventing postpartum haemorrhage and reducing maternal mortality in childbirth.
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References
Adair, F.L., Haugen, J.A.: A study of suspended human uterine muscle strips in vitro. Amer. J. Obstet. Gynec. 37, 753–762 (1939)
Adair, F.L., Davis, M.E.: A study of human uterine motility. Amer. J. Obstet. Gynec. 27, 383–394 (1934)
Adair, F.L., Davis, M.E., Kharasch, M.S., Legault, R.R.: A study of a new potent ergot derivative, ergotocin. Amer. J. Obstet. Gynec. 30, 466–480 (1935)
Altman, S.G., Waltman, R., Lubin, S., Reynolds, S.R.M.: Oxytocic and toxic actions of dihydroergotamine-45. Amer. J. Obstet. Gynec. 64, 101–109 (1952)
Alvarez, H.: Discussion: motility of parts of human uterus. In: Oxytocin. Caldeyro-Barcia, R., Heller, H. (eds.), pp. 309–311. Oxford: Pergamon Press 1961
Alvarez, H., Caldeyro, R.: Contractility of the human uterus recorded by new methods. Surg. Gynec. Obstet. 91, 1–13 (1950)
Alvarez, H., Mendez-Bauer, C., Sica Blanco, Y.: Actión de la hydergina sobre la contractilidad del utero húmano grávido. An. Ginecotocol. 2, 67–72 (1954–55)
Bachbauer, A.: Über die Wirkung eines halbsynthetischen Sekalealkaloids als Wehenmittel auf tokometrischer Grundlage. Geburtsh. u. Frauenheilk. 6, 278–289 (1944)
Barger, G.: The alcaloids of ergot. In: Handbuch der experimentellen Pharmakologie, Vol. VI, Heubner, W., Schuller, J. (eds.), pp. 130–134, 177–179, 185–190. Berlin-Heidelberg-New York: Springer 1938
Baskin, M.J., Crealock, F.W.: The management of cervical spasm with dihydroergotamine methanesulfonate (DHE-45). West. J. Surg. 58, 302–307 (1950)
Baumgarten, K.: Die Uterusmotilität beim weiblichen Zyklus. Geburtsh. u. Frauenheilk. 30, 921–933 (1970)
Baumgarten, K., Fröhlich, H., Seidl, A., Sokol, K., Lim-Rachmat, F., Hager, R.: A new β-sympathomimetic preparation for intravenous and oral inhibition of uterine contractions. Europ. J. Obstet. Gynec. 1, 69–83 (1971)
Berde, B.: Discussion: motility of parts of human uterus. In: Oxytocin. Caldeyro-Barcia, R., Heller, H. (eds.), p. 309. Oxford: Pergamon Press 1961
Berde, B., Cerletti, A.: Quantitative comparison of substances related to oxytocin: a new test. Acta endocr. (Kbh.) 27, 314–324 (1958)
Berde, B., Rothlin, E.: Über die Uteruswirkung hydrierter Mutterkornalkaloide an Kaninchen und Katzen vor, während und nach der Geburt. Helv. physiol. pharmacol. Acta 11, 274–282 (1953)
Berde, B., Saameli, K.: Evaluation of substances acting on the uterus. In: Methods in Drug Evaluation. Mantegazza, P., Piccinini, F. (eds.), pp. 481–514. Amsterdam: North-Holland Publishing Company 1966
Berde, B., Stürmer, E.: The biological assay of oxytocin in the presence of ergometrine. J. Pharm. Pharmacol. 14, 169–171 (1962)
Bosch, K.: Über die Entwicklung, Technik und Resultate der kontinuierlichen Amniondruckmessung und ihrer Kombination mit simultaner externer Tokographie sub partu. Schweiz. med. Wschr. 84, 850–855 (1954)
Bourne, A., Burn, J.H.: The dosage and action of pituitary extract and of the ergot alkaloids on the uterus in labour, with a note on the action of adrenalin. J. Obstet. Gynaec. Brit. Emp. 34, 249–268 (1927)
Bourne, A.W., Burn, J.H.: Oxytocin and vasopressin on the uterus in labour. Lancet 1928 II, 694–695
Bourne, A.W., Burn, J.H.: Action on the human uterus of anaesthetics and other drugs commonly used in labour. Brit. med. J. 2, 87–89 (1930)
Broom, A.W., Clark, A.J.: The standardisation of ergot preparations. J. Pharmacol. exp. Ther. 22, 59–74 (1923)
Brown, G.L., Dale, H.: The pharmacology of ergometrine. Proc. roy. Soc. B118, 446–477 (1935)
Brügger, I.: Experimenteller Beitrag zur Wirkungsweise vegetativer Pharmaka. Arch. int. Pharmacodyn. 59, 43–60 (1938)
Bruns, P.D., Snow, R.H., Drose, V.E.: Effect of dihydroergotamine on human uterine contractility. Obstet. and Gynec. 1, 188–196 (1953)
Carballo, M.A., Caldeyro Barcia, R., Alvarez, H., Agüero, O., Mendy, J.C.: Accion de la metilergonovina sobre la contractilidad uterina durante el alumbramiento. Bol. Soc. chil. Obstet. Ginec. 18, 252–263 (1953)
Cibils, L.A., Hendricks, C.H.: Effect of ergot derivatives and sparteine sulfate upon the human uterus. J. Reprod. Med. 2, 147–167 (1969)
Clegg, P.C.: The effect of adrenergic blocking agents on the guinea-pig uterus in vitro, and a study of the histology of the intrinsic myometrial nerves. J. Physiol. (Lond.) 169, 73–90 (1963)
Coutinho, E.M.: Tubal and uterine motility. In: Proceedings of the 15th Nobel Symposium 1970, Sweden. Diczfalusy, E., Borell, U. (eds.), pp. 97–115. New York-London-Sydney: Wiley 1971
Coutinho, E.M., Maia, H., Nascimento, L.: The response of the human Fallopian tube to ergonovine and methyl-ergonovine in vivo. Amer. J. Obstet. Gynec. 126, 48–54 (1976)
Daels, J.: Uterine contractility patterns of the outer and inner zones of the myometrium. Obstet. and Gynec. 44, 315–326 (1974)
Dale, H.H.: The new ergot alkaloid. Science 82, 99–101 (1935)
Dale, H.H., Spiro, K.: Die wirksamen Alkaloide des Mutterkorns. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 95, 337–350 (1922)
Davis, M.E., Adair, F.L., Rogers, G., Kharasch, M.S., Legault, R.R.: A new active principle in ergot and its effects on uterine motility. Amer. J. Obstet. Gynec. 29, 155–167 (1935a)
Davis, M.E., Adair, F.L., Chen, K.K., Swanson, E.E.: The pharmacologic action of ergotoxin, a new ergot principle. J. Pharmacol. exp. Ther. 54, 398–407 (1935b)
Davis, M.E., Adair, F.L., Pearl, S.: The present status of oxytocics in obstetrics. J. Amer. med. Ass. 107, 261–267 (1936)
De Boer, J., Van Dongen, K.: Experiments with dihydroergotamine. Arch. int. Pharmacodyn. 77, 434–441 (1948)
Deis, R.P., Pickford, M.: The effect of autonomic blocking agents on uterine contractions of the rat and the guinea-pig. J. Physiol. (Lond.) 173, 215–225 (1964)
De Koning Gans, H.J., Martinez, A.A.V., Eskes, T.K.A.B.: Intermittent low-dose administration of prostaglandins intra-amniotically in pathological pregnancies. Europ. J. Obstet. Gynec. Reprod. Biol. 5/6, 307–315 (1975)
Dudley, H.W., Moir, C.: The substance responsible for the traditional clinical effect of ergot. Brit. med. J. 1, 520–523 (1935)
Embrey, M.P.: Simultaneous intramuscular injection of oxytocin and ergometrine: a tocography study. Brit. med. J. 1, 1737–1738 (1961)
Embrey, M.P., Garrett, W.J.: A study of the effects of dihydroergotamine on the intact human uterus. J. Obstet. Gynaec. Brit. Emp. 62, 150–154 (1955)
Embrey, M.P., Garrett, W.J.: Ergometrine with hyaluronidase: speed of action. Brit. med. J. 2, 138–139 (1958)
Eschbach, W., Hanke, R.: Uterusmotilität post abortum. Zbl. Gynäk. 75, 481–489 (1953)
Fanchamps, A., Doepfner, W., Weidmann, H., Cerletti, A.: Pharmakologische Charakterisierung von Deseril®, einem Serotonin-Antagonisten. Schweiz. med. Wschr. 90, 1040–1046 (1960)
Fegerl, H., Narik, G.: Die Beeinflussung der Wehentätigkeit durch das sympathische und parasympathische Nervensystem. Geburtsh. u. Frauenheilk. 11, 822–834 (1951)
Flury, F.: Pharmakologische Untersuchungen am ausgeschnittenen menschlichen Uterus. Z. Geburtsh. Gynäk. 87, 291–300 (1924)
Foster, G.E., Stewart, G.A.: The stability of ergometrine preparations, chemical and biological studies. Quart. J. Pharmacol. 21, 211–218 (1948)
Fraser, A.M.: The effect of magnesium on the response of the uterus to posterior pituitary hormones. J. Pharmacol. exp. Ther. 66, 85–94 (1939)
Fregnan, G.B., Glässer, A.H.: Activity of eledoisin, other polypeptides and ergometrine on the uterus in situ of rabbit and other animal species. J. Pharm. Pharmacol. 16, 744–750 (1964)
Fröhlich, H.: Steuermechanismen der Motilitat des nichtgraviden Uterus in situ. Wien. klin. Wschr. 86 (Suppl. 24), 3–28 (1974)
Fuchs, A.-R., Fuchs, F.: The effect of oxytocic substances upon the rabbit uterus in situ. Acta physiol. scand. 49, 103–113 (1960)
Garg, K.N., Sharma, S., Bala, S.: Experimental studies of sparteine sulphate on strips of human uterus. Jap. J. Pharmacol. 23, 195–200 (1973)
Garrett, W.J.: The effects of adrenaline, noradrenaline and dihydroergotamine on excised human myometrium. Brit. J. Pharmacol. 10, 39–44 (1955)
Garrett, W.J.: A theory of uterine action. J. Obstet. Gynaec. Brit. Emp. 66, 927–938 (1959)
Garrett, W.J.: Why ergometrine? A review of ergot in practice today. Med. J. Aust. 47/1, 677–680 (1960)
Garrett, W.J., Embrey, M.P.: The effect of the hydrogenated ergotoxine-group alkaloids on the intact human uterus. J. Obstet. Gynaec. Brit. Emp. 62, 523–529 (1955)
Garrett, W.J., Moir, J.C.: Ergot and the non-pregnant uterus. J. Obstet. Gynaec. Brit. Emp. 65, 583–587 (1958)
Gill, R.C.: The effect of methyl-ergometrine on the human puerperal uterus. J. Obstet. Gynaec. Brit. Emp. 54, 482–488 (1947)
Gill, R.C.: Further observations on the effect of dihydroergotamine upon human uterine action. J. Obstet. Gynaec. Brit. Emp. 60, 103–109 (1953)
Gill, R.C., Farrar, J.M.: Experiences with di-hydro-ergotamine in the treatment of primary uterine inertia. J. Obstet. Gynaec. Brit. Emp. 58, 79–91 (1951)
Härtfelder, G., Kuschinsky, G., Mosler, H.K.: Über pharmakologische Wirkungen an elektrisch gereizten glatten Muskeln. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 234, 66–78 (1953)
Hendricks, C.H., Brenner, W.E.: Cardiovascular effects of oxytocic drugs used post partum. Amer. J. Obstet. Gynec. 108, 751–760 (1970)
Hendricks, C.H., Reid, D.W.J., Van Fraagh, I., Cibils, L.A.: Effect of sparteine sulfate upon uterine activity in human pregnancy. Amer. J. Obstet. Gynec. 91, 1–9 (1965)
Hool-Zulauf, B., Stürmer, E.: Oxytocic activity of two dihydro-ergot peptide alkaloids on the rabbit uterus in situ. Abstr. of the 17th Spring Meeting, March 23–26, 1976, Mainz. Naunyn-Schmiedebergs Arch. Pharmacol. 293 (Suppl.), 139 (1976)
Hool-Zulauf, B., Stürmer, E.: Oxytocic activity of two dihydrogenated ergot peptide alkaloids on the rabbit uterus in situ. Arzneimittel-Forsch. 27, 2323–2325 (1977)
Huber, R.: Tokographische Kontrolle einiger gebrauchlicher Sekale-Rein-Alkaloide am menschlichen Uterus post partum. Zbl. Gynak. 78, 748–756 (1956)
Ingelman-Sundberg, A., Lindgren, L., Ryden, G., Sandberg, F.: The spontaneous motility of uterine fibromyomata and their responses to pharmacological stimuli. Acta obstet. gynec. scand. 36, 263–269 (1957)
Ivy, A.C., Hartman, C.G., Koff, A.: The contractions of the monkey uterus at term. Amer. J. Obstet. Gynec. 22, 388–399 (1931)
Jeffcoate, T.N.A., Wilson, J.K.: The effect of hydergine on uterine action. Lancet 1955 I, 1187–1190
Jelinek, E.: Resultate der oralen Anwendung von Hydergin während der 1. Geburtsphase. Gynaecologia (Basel) 143, 414–425 (1957)
Kharasch, M.S., King, H., Stoll, A., Thompson, M.R.: The new ergot alkaloid. Science 83, 206–207 (1936)
Kimbell, N.: Intramuscular ergometrine and hyaluronidase in prevention of post-partum haemorrhage. Brit. med. J. 2, 130–131 (1954)
Kirchhof, A.C., Racely, C.A., Wilson, W.M., David, N.A.: An ergonovine-like oxytocic synthetized from lysergic acid. West. J. Surg. 52, 197–208 (1944)
Koff, A.K.: A study of the action of ergot on the human puerperal uterus. Surg. Gynec. Obstet. 60, 190–202 (1935)
Konzett, H.: Specific antagonism of dibenamine to ergometrine. In: Ciba Foundation Symposium on Adrenergic Mechanism. Wolstenholme, G.E.W., O’Connor, M. (eds.), pp. 463–465. London: Churchill 1960
Kremer, H., Narik, G.: Die pharmakodynamische Beeinflußbarkeit der Uterusmotorik sub partu. Geburtsh. u. Frauenheilk. 15, 433–443 (1955)
Mayer, M., Halpern, B., Nogueira, I.: Accouchement — Délivrance; étude pharmacodynamique de certaines substances utéro-sédatives et utéro-contracturantes. Bull. Féd. Soc. Gynéc. Obstét. franč. 7, 591–604 (1955)
Miller, G.B., De Beer, E.J.: The ability of ergotoxine to modify the contractile action of ergonovine on the isolated uterus. J. Pharmacol. exp. Ther. 104, 412–415 (1952)
Moir, C.: Clinical comparison of ergotoxine and ergotamine. Brit. med. J. 1, 1022–1024 (1932a)
Moir, C.: The action of ergot preparations on the puerperal uterus. Brit. med. J. 1, 1119–1122 (1932b)
Moir, C.: The effect of posterior lobe pituitary gland fractions on the intact human uterus. J. Obstet. Gynaec. Brit. Emp. 51, 181–197 (1944)
Moir, C., Russel, C.S.: An investigation of the effect of ergot alkaloids in promoting involution of the postpartum uterus. J. Obstet. Gynaec. Brit. Emp. 50, 94–104 (1943)
Moir, J.C.: The obstetrician bids, and the uterus contracts. Brit. med. J. 2, 1025–1029 (1964)
Müller, H.A., Ströker, W.: Studien über die Uterusmotilität. Die spontane Motilität in der Postplacentarperiode und Methergin wirkung. Arch. Gynäk. 191, 369–376 (1959)
Myerscough, P.R., Schild, H.O.: Quantitative assays of oxytocic drugs on the human postpartum uterus. Brit. J. Pharmacol. 13, 207–212 (1958)
Nelson, E.E., Calvery, H.O.: Present status of the ergot question. Physiol. Rev. 18, 297–327 (1938)
Oettel, H., Bachmann, H.: Untersuchungen am puerperalen Säugeruterus über Hypophysin, Ergometrin und Mutterkornextrakte. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 185, 242–258 (1937)
Orth, O.S.: Studies of the sympathicolytic drug dihydroergotamine (D.H.E. 45). Fed. Proc. 5, 196 (1946)
Orth, O.S., Ritchie, G.: A pharmacological evaluation of dihydroergotamine methanesulfonate (D.H.E. 45). J. Pharmacol. exp. Ther. 90, 166–173 (1947)
Pennefather, J.N.: The estimation of ergometrine on the rat uterus. J. Pharm. Pharmacol. 13, 60–61 (1961)
Pereira Martinez, A., Del Sol, J.R., Slocker, Castro, C.: Los alcaloides dihydrogenados del cornezuelo de centeno en obstetricia. Acta ginec. (Madr.) 1, 7–18 (1954)
Reist, A.: Neuere Auffassungen über Wesen und Behandlung von geburtsstörenden Anomalien des Weichteilweges. In: Schweizerisches Medizinisches Jahrbuch, pp. XLI–LVII. Basel: Schwabe 1949
Reynolds, S.R.M., Harris, J.S., Kaiser, I.H.: Effects of adrenalin and noradrenalin on uterine contractions. In: Clinical Measurements of Uterine Forces in Pregnancy and Labor, p. 221. Springfield Ill.: Thomas 1954
Robson, J.M.: The reactivity and activity of the human uterus at various stages of pregnancy and at parturition. J. Physiol. (Lond.) 79, 83–93 (1933)
Roth-Brandel, U., Bygdeman, M., Wiqvist, N.: A comparative study on the influence of prostaglandin Et, oxytocin and ergometrin on the pregnant human uterus. Acta obstet. gynec. scand. 49 (Suppl. 5), 1–7 (1970)
Rothlin, E.: Über die pharmakologische und therapeutische Wirkung des Ergotamins auf den Sympathicus. Klin. Wschr. 30, 1437–1443 (1925)
Rothlin, E.: Sur les propriétés pharmacologiques d’un nouvel alcaloïde de l’ergot de seigle, l’ergobasine. C.R. Soc. Biol. (Paris) 119, 1302–1311 (1935a)
Rothlin, E.: Über ein neues Mutterkornalkaloid. Schweiz. med. Wschr. 65, 947–949 (1935b)
Rothlin, E.: Beitrag zur differenzierenden Analyse der Mutterkornalkaloide. Schweiz. med. Wschr. 68, 971–975 (1938a)
Rothlin, E.: Chemisch-pharmakologische Stellungnahme zum Mutterkornproblem. Arch. Gynäk. 166, 88–105 (1938b)
Rothlin, E.: Zur Pharmakologie der hydrierten naturlichen Mutterkornalkaloide. Helv. physiol. Pharmacol. Acta 2, C48–C49 (1944)
Rothlin, E.: Zur Pharmakologie des Sympathicolyticums Dihydroergotamin DHE 45. Schweiz. med. Wschr. 76, 1254–1259 (1946)
Rothlin, E.: The pharmacology of the natural and dihydrogenated alkaloids of ergot. Bull. schweiz. Akad. med. Wiss. 2, 249–273 (1946/47)
Rothlin, E.: Pharmacology of lysergic acid diethylamide and some of its related compounds. J. Pharm. Pharmacol. 9, 569–587 (1957)
Rothlin, E., Berde, B.: Über die Wirkung hydrierter Mutterkornalkaloide auf isolierte Muskelstreifen des menschlichen Uterus nahe am Termin, am Termin und während der Geburt. Helv. physiol. pharmacol. Acta 12, 191–205 (1954)
Rothlin, E., Brügger, J.: Quantitative Untersuchungen der sympathikolytischen Wirkung genuiner Mutterkornalkaloide und derer Dihydroderivate am isolierten Uterus des Kaninchens. Helv. physiol. pharmacol. Acta 3, 519–535 (1945)
Rudzik, A.D., Miller, J.W.: The mechanism of uterine inhibitory action of relaxin-containing ovarian extracts. J. Pharmacol. exp. Ther. 138, 82–87 (1962)
Sandberg, F., Ingelman-Sundberg, A., Lindgren, L., Ryden, G.: Comparison of in vitro and in vivo effects of four synthetic oxytocics on pregnant human uterus. Arzneimittel-Forsch. 9, 544–548 (1959)
Sandberg, F., Ingelman-Sundberg, A., Lindgren, L., Ryden, G.: The effect of oxytocin on the motility of different parts of the pregnant and non-pregnant human uterus in vitro as compared with other oxytocic drugs. In: Oxytocin. Caldeyro-Barcia, R., Heller, H. (eds.), pp. 295–312. Oxford: Pergamon Press 1961
Sauter, H.: Verwendung von Dihydroergotamin (DHE 45) in der Geburtshilfe. Schweiz. med. Wschr. 78, 475–480 (1948)
Sauter, H.: Gefäßwirkung verschiedener Pharmaka, insbesondere von Adrenalin und der dihydrierten Secalealkaloide beim postpartalen menschlichen Uterus. Schweiz. med. Wschr. 79, 572–576 (1949a)
Sauter, H.: Die konstriktorische Wirkung verschiedener Wehenmittel auf die Uterusgefäße. Gynaecologia (Basel) 127, 302–324 (1949b)
Sauter, H.: Beziehungen zwischen Uterustonus und Uterusdurchblutung. Schweiz. med. Wschr. 80, 1306–1309 (1950)
Schild, H.O.: The use of incomplete randomized blocks in an oxytocic assay. In: Quantitative Methods in Human Pharmacology and Therapeutics: Proceedings of a Symposium Held in London, March, 1958. Laurence, D.R. (ed.), pp. 154–159. London: Pergamon Press 1959
Schild, H.O., Fitzpatrick, R.J., Nixon, W.C.W.: Activity of the human cervic and corpus uteri. Lancet 1951 I, 250–253
Shaaban, A.H., Youssef, A.F.: Effect of autonomic drugs on uterine action in labour. Gaz. Egypt. Soc. Gynaec. Obstet. 9, 107–132 (1959)
Slaytor, M., Pennefather, J.N., Wright, S.E.: Metabolites of LSD and ergometrine. Experientia (Basel) 15, 111 (1959)
Smith, R.G.: The present status of ergonovine. J. Amer. med. Ass. 111, 2201–2209 (1938)
Smyth, C.N.: A comparison of the effects of oxytocin and ergometrine on the human uterus. In: Oxytocin. Caldeyro-Barcia, R., Heller, H. (eds.), pp. 281–294. Oxford: Pergamon Press 1961
Snow, R.H., Bruns, P.D., Drose, V.E.: Effect of hydergine (dihydrogenated ergot) on preeclampsia and uterine contractility. Amer. J. Obstet. Gynec. 70, 302–307 (1955)
Stoll, A., Burckhardt, E.: L’ergobasine, un nouvel alcaloïde de l’ergot de seigle, soluble dans l’eau. C.R. Acad. Sci. (Paris) 200, 1680–1682 (1935)
Stolte, L.A.M., Eskes, T.K.A.B., Seelen, J.C.: Uterine activity and adrenaline derivatives. Acta physiol. pharmacol. need. 12, 179–180 (1963)
Stürmer, E., Flückiger, E.: In vivo smooth muscle stimulant activity of 2-bromo-α-ergokryptine mesylate (CB 154) as compared with that of ergotamine. IRCS med. Sci. 2, 1591 (1974)
Sund, R.B.: On the actions of ergometrine on isolated rat uterus in absence and presence of magnesium ions. Medd. norske farm. Selsk. 25, 89–96 (1963a)
Sund, R.B.: Assay of oxytocin in pharmaceutical solutions containing both oxytocin and ergometrine, by the isolated rat uterus method. Medd. norske farm. Selsk. 25, 101–114 (1963b)
Swanson, E.E., Hargreaves, C.C.: The action of ergot and its alkaloids on the puerperal uteri of dogs. J. Amer. pharm. Ass. sci. Ed. 23, 867–872 (1934)
Thompson, M.R.: Some properties of ergostetrine. J. Amer. pharm. Ass. 24, 748–753 (1935)
Tothill, A.: Investigation of adrenaline reversal in the rat uterus by the induction of resistance to isoprenaline. Brit. J. Pharmacol. 29, 291–301 (1967)
Tuck, V.L.: A clinical test of the newly recognized oxytocic principle of ergot and a new method of administration. Amer. J. Obstet. Gynecol. 5, 718–723 (1935)
Venkatasubbu, V.S., Gopala Krishnamurthy, L.B.: Pharmacological and clinical evaluation of the action of hydrogenated ergot alkaloids on the uterus. Curr. Med. Pract. 3, 629–638 (1959)
Vos, Jr., B.J.: Use of the latent period in the assay of ergonovine on the isolated rabbit uterus. J. Amer. pharm. Ass. sci. Ed. 32, 138–141 (1943)
Votava, Z., Podvalova, I.: Pharmacological studies of ergometrine and methylergometrine. Acta pharmacol. (Kbh.) 13, 309–318 (1957)
Wellhöner, H.-H.: Wirkung von Pharmaka auf die glatte Muskulatur der Scheide. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 236, 167 (1959a)
Wellhöner, H.-H.: Antagonistische Beeinflussung der Methylergobasinwirkung an Uterus und Vagina durch einige Sympathicolytika und Adrenolytika. Med. exp. (Basel) 1, 138–145 (1959b)
Wilhelm, F.: Verwendungsmöglichkeiten des Hydergin in der Geburtshilfe. Klin. Med. (Wien) 6, 414–421 (1951)
Wiqvist, N.: Desensitizing effect of exo-and endogenous relaxin on the immediate uterine response to relaxin. Acta endocr. (Kbh.) 46 (Suppl.), 3–14 (1959)
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Saameli, K. (1978). Effects on the Uterus. In: Berde, B., Schild, H.O. (eds) Ergot Alkaloids and Related Compounds. Handbook of Experimental Pharmacology / Handbuch der experimentellen Pharmakologie, vol 49. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66775-6_4
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