Abstract
MRI is becoming increasingly useful for imaging of lung structure and function, both in terms of airways imaging, assessment of ventilation and evaluation of lung perfusion and right heart function. This modality is highly versatile and capable of generating a range of inherent and exogenously introduced contrast mechanisms, while maintaining high resolution as well as incredible speed of data acquisition. It is quite likely that MRI techniques will allow further evaluation of physiological and pathophysiological aspects of COPD, and this should ultimately lead to improved understanding and treatment of this heterogeneous diseases complex.
Access provided by Autonomous University of Puebla. Download to read the full chapter text
Chapter PDF
Similar content being viewed by others
Keywords
- Chronic Obstructive Pulmonary Disease
- Apparent Diffusion Coefficient
- Chronic Obstructive Pulmonary Disease Patient
- Magn Reson Image
- Mean Transit Time
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Amundsen T, Torheim G, Kvistad KA et al. (2002) Perfusion abnormalities in pulmonary embolism studied with perfusion MRI and ventilation-perfusion scintigraphy: an intra-modality and inter-modality agreement study. J Magn Reson Imaging 15:386–394
Bankier AA, O’Donnell CR, Mai VM et al. (2004) Impact of lung volume on MR signal intensity changes of the lung parenchyma. J Magn Reson Imaging 20:961–966
Biederer J, Both M, Graessner J et al. (2003) Lung morphology: fast MR imaging assessment with a volumetric interpolated breath-hold technique: initial experience with patients. Radiology 226:242–249
Boxt LM (1996) MR imaging of pulmonary hypertension and right ventricular dysfunction. Magn Reson Imaging Clin N Am 4:307–325
Budev MM, Arroliga AC, Wiedemann HP et al. (2003) Cor pulmonale: an overview. Semin Respir Crit Care Med 24:233–244
Cluzel P, Similowski T, Chartrand-Lefebvre C et al. (2000) Diaphragm and chest wall: assessment of the inspiratory pump with MR imaging-preliminary observations. Radiology 215:574–583
Conradi MS, Yablonskiy DA, Woods JC et al. (2005) 3He diffusion MRI of the lung. Acad Radiol 12:1406–1413
Decramer M (1997) Hyperinflation and respiratory muscle interaction. Eur Respir J 10:934–941
Edelman RR, Hatabu H, Tadamura E et al. (1996) Noninvasive assessment of regional ventilation in the human lung using oxygen-enhanced magnetic resonance imaging. Nat Med 2:1236–1239
Eichinger M, Tetzlaff R, Puderbach M et al. (2007) Proton magnetic resonance imaging for assessment of lung function and respiratory dynamics. Eur J Radiol 64:329–334
Fink C, Puderbach M, Bock M et al. (2004) Regional lung perfusion: assessment with partially parallel three-dimensional MR imaging. Radiology 231:175–184
Fink C, Ley S, Kroeker R et al. (2005) Time-resolved contrast-enhanced three-dimensional magnetic resonance angiography of the chest: combination of parallel imaging with view sharing (TREAT). Invest Radiol 40:40–48
Gast KK, Viallon M, Eberle B et al. (2002) MRI in lung transplant recipients using hyperpolarized (3)He: Comparison with CT. J Magn Reson Imaging 15:268–274
Gast KK, Puderbach MU, Rodriguez I et al. (2003) Distribution of ventilation in lung transplant recipients: evaluation by dynamic 3He-MRI with lung motion correction. Invest Radiol 38:341–348
Gatehouse PD, Keegan J, Crowe LA et al. (2005) Applications of phase-contrast flow and velocity imaging in cardiovascular MRI. Eur Radiol 15:2172–2184
Gierada DS, Saam B, Yablonskiy D et al. (2000) Dynamic echo planar MR imaging of lung ventilation with hyperpolarized (3)He in normal subjects and patients with severe emphysema. NMR Biomed 13:176–181
Guenther D, Eberle B, Hast J et al. (2000) (3)He MRI in healthy volunteers: preliminary correlation with smoking history and lung volumes. NMR Biomed 13:182–189
Gust R, Kozlowski J, Stephenson AH et al. (1998) Synergistic hemodynamic effects of low-dose endotoxin and acute lung injury. Am J Respir Crit Care Med 157:1919–1926
Henderson AC, Ingenito EP, Salcedo ES et al. (2007) Dynamic lung mechanics in late-stage emphysema before and after lung volume reduction surgery. Respir Physiol Neurobiol 155:234–242
Heussel CP, Ley S, Biedermann A et al. (2004) Respiratory lumenal change of the pharynx and trachea in normal subjects and COPD patients: assessment by cine-MRI. Eur Radiol 14:2188–2197
Hogg JC, Chu F, Utokaparch S et al. (2004) The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 350:2645–2653
Iwasawa T, Yoshiike Y, Saito K et al. (2000) Paradoxical motion of the hemidiaphragm in patients with emphysema. J Thorac Imaging 15:191–195
Iwasawa T, Kagei S, Gotoh T et al. (2002) Magnetic resonance analysis of abnormal diaphragmatic motion in patients with emphysema. Eur Respir J 19:225–231
Iwasawa T, Takahashi H, Ogura T et al. (2007) Correlation of lung parenchymal MR signal intensity with pulmonary function tests and quantitative computed tomography (CT) evaluation: a pilot study. J Magn Reson Imaging 26:1530–1536
Kauczor HU, Hofmann D, Kreitner KF et al. (1996) Normal and abnormal pulmonary ventilation: visualization at hyperpolarized He-3 MR imaging. Radiology 201:564–568
Lehmann F, Knitz F, Weiler N et al. (2004) A software tool for analysis and quantification of regional pulmonary ventilation using dynamic hyperpolarised-(3)He-MRI. Rofo 176:1399–1408
Ley S, Fink C, Puderbach M et al. (2004a) Contrast-enhanced 3D MR perfusion of the lung: application of parallel imaging technique in healthy subjects. Rofo 176:330–334
Ley S, Zaporozhan J, Morbach A et al. (2004b) Functional evaluation of emphysema using diffusion-weighted 3Helium-magnetic resonance imaging, high-resolution computed tomography, and lung function tests. Invest Radiol 39:427–434
Ley S, Puderbach M, Risse F et al. (2007) Impact of oxygen inhalation on the pulmonary circulation: assessment by magnetic resonance (MR)-perfusion and MR-flow measurements. Invest Radiol 42:283–290
Ley-Zaporozhan J, Ley S, Eberhardt R et al. (2007) Assessment of the relationship between lung parenchymal destruction and impaired pulmonary perfusion on a lobar level in patients with emphysema. Eur J Radiol 63:76–83
Ley-Zaporozhan J, Ley S, Kauczor HU (2008) Morphological and functional imaging in COPD with CT and MRI: present and future. Eur Radiol 18:510-21
Ley-Zaporozhan J, Puderbach M, Kauczor HU (2008) MR for the evaluation of obstructive pulmonary disease. Magn Reson Imaging Clin N Am 16:291–308
Loffler R, Muller CJ, Peller M et al. (2000) Optimization and evaluation of the signal intensity change in multisection oxygen-enhanced MR lung imaging. Magn Reson Med 43:860–866
Molinari F, Fink C, Risse F et al. (2006) Assessment of differential pulmonary blood flow using perfusion magnetic resonance imaging: comparison with radionuclide perfusion scintigraphy. Invest Radiol 41:624–630
Moonen M, Xu J, Johansson A et al. (2005) Effects of lung volume reduction surgery on distribution of ventilation and perfusion. Clin Physiol Funct Imaging 25:152–157
Morbach AE, Gast KK, Schmiedeskamp J et al. (2005) Diffusion-weighted MRI of the lung with hyperpolarized helium-3: a study of reproducibility. J Magn Reson Imaging 21:765–774
Morino S, Toba T, Araki M et al. (2006) Noninvasive assessment of pulmonary emphysema using dynamic contrast-enhanced magnetic resonance imaging. Exp Lung Res 32:55–67
Muller CJ, Schwaiblmair M, Scheidler J et al. (2002) Pulmonary diffusing capacity: assessment with oxygen-enhanced lung MR imaging preliminary findings. Radiology 222:499–506
Ohno Y, Chen Q, Hatabu H (2001) Oxygen-enhanced magnetic resonance ventilation imaging of lung. Eur J Radiol 37:164–171
Ohno Y, Sugimura K, Hatabu H (2003) Clinical oxygen-enhanced magnetic resonance imaging of the lung. Top Magn Reson Imaging 14:237–243
Ohno Y, Hatabu H, Higashino T et al. (2004a) Dynamic perfusion MRI versus perfusion scintigraphy: prediction of postoperative lung function in patients with lung cancer. AJR Am J Roentgenol 182:73–78
Ohno Y, Hatabu H, Murase K et al. (2004b) Quantitative assessment of regional pulmonary perfusion in the entire lung using three-dimensional ultrafast dynamic contrast-enhanced magnetic resonance imaging: preliminary experience in 40 subjects. J Magn Reson Imaging 20:353–365
Plathow C, Fink C, Ley S et al. (2004) Measurement of diaphragmatic length during the breathing cycle by dynamic MRI: comparison between healthy adults and patients with an intrathoracic tumor. Eur Radiol 14:1392–1399
Plathow C, Schoebinger M, Fink C et al. (2005) Evaluation of lung volumetry using dynamic three-dimensional magnetic resonance imaging. Invest Radiol 40:173–179
Rabe KF, Hurd S, Anzueto A et al. (2007) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 176:532–555
Ray N, Acton ST, Altes T et al. (2003) Merging parametric active contours within homogeneous image regions for MRI-based lung segmentation. IEEE Trans Med Imaging 22:189–199
Rosenkranz S (2007) Pulmonary hypertension: current diagnosis and treatment. Clin Res Cardiol 96(8):527–541
Salerno M, Altes TA, Brookeman JR et al. (2001) Dynamic spiral MRI of pulmonary gas flow using hyperpolarized (3)He: preliminary studies in healthy and diseased lungs. Magn Reson Med 46:667–677
Salerno M, de Lange EE, Altes TA et al. (2002) Emphysema: hyperpolarized helium 3 diffusion MR imaging of the lungs compared with spirometric indexes – initial experience. Radiology 222:252–260
Sandek K, Bratel T, Lagerstrand L et al. (2002) Relationship between lung function, ventilation-perfusion inequality and extent of emphysema as assessed by high-resolution computed tomography. Respir Med 96:934–943
Schuster DP, Marklin GF (1986) Effect of changes in inflation and blood volume on regional lung density – a PET study: 2. J Comput Assist Tomogr 10:730–735
Sergiacomi G, Sodani G, Fabiano S et al. (2003) MRI lung perfusion 2D dynamic breath-hold technique in patients with severe emphysema. In Vivo 17:319–324
Stadler A, Jakob PM, Griswold M et al. (2008) T(1) mapping of the entire lung parenchyma: Influence of respiratory phase and correlation to lung function test results in patients with diffuse lung disease. Magn Reson Med 59:96–101
Suga K, Tsukuda T, Awaya H et al. (1999) Impaired respiratory mechanics in pulmonary emphysema: evaluation with dynamic breathing MRI. J Magn Reson Imaging 10:510–520
Swift AJ, Wild JM, Fichele S et al. (2005) Emphysematous changes and normal variation in smokers and COPD patients using diffusion 3He MRI. Eur J Radiol 54:352–358
Swift AJ, Woodhouse N, Fichele S et al. (2007) Rapid lung volumetry using ultrafast dynamic magnetic resonance imaging during forced vital capacity maneuver: correlation with spirometry. Invest Radiol 42:37–41
Szilasi M, Dolinay T, Nemes Z et al. (2006) Pathology of chronic obstructive pulmonary disease. Pathol Oncol Res 12:52–60
Thabut G, Dauriat G, Stern JB et al. (2005) Pulmonary hemodynamics in advanced COPD candidates for lung volume reduction surgery or lung transplantation. Chest 127:1531–1536
van Beek EJ, Wild JM, Kauczor HU et al. (2004) Functional MRI of the lung using hyperpolarized 3-helium gas. J Magn Reson Imaging 20:540–554
Vonk Noordegraaf A, Marcus JT, Roseboom B et al. (1997) The effect of right ventricular hypertrophy on left ventricular ejection fraction in pulmonary emphysema. Chest 112:640–645
Vonk-Noordegraaf A, Marcus JT, Holverda S et al. (2005) Early changes of cardiac structure and function in COPD patients with mild hypoxemia. Chest 127:1898–1903
Weitzenblum E, Chaouat A (2005) Severe pulmonary hypertension in COPD: is it a distinct disease? Chest 127:1480–1482
Wild JM, Paley MN, Kasuboski L et al. (2003) Dynamic radial projection MRI of inhaled hyperpolarized 3He gas. Magn Reson Med 49:991–997
Woodhouse N, Wild JM, Paley MN et al. (2005) Combined helium-3/proton magnetic resonance imaging measurement of ventilated lung volumes in smokers compared to never-smokers. J Magn Reson Imaging 21:365–369
Zaporozhan J, Ley S, Gast KK et al. (2004) Functional analysis in single-lung transplant recipients: a comparative study of high-resolution CT, (3)He-MRI, and pulmonary function tests. Chest 125:173–181
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Ley-Zaporozhan, J., Halaweish, A., van Beek, E. (2009). Chronic Obstructive Pulmonary Diseases. In: Kauczor, HU. (eds) MRI of the Lung. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-34619-7_9
Download citation
DOI: https://doi.org/10.1007/978-3-540-34619-7_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-34618-0
Online ISBN: 978-3-540-34619-7
eBook Packages: MedicineMedicine (R0)