Abstract
A variety of membrane transport systems responsible for the regulation of intracellular pH (pHi) have been identified in smooth muscle (Aickin, 1986; Aalkjaer and Cragoe, 1988; Wray, 1988; Kikeri et al., 1990) and smooth musclelike cells (Boyarsky et al.,1988a,b; Putnam,1990). These include the ubiquitous Na/H exchanger and at least two HC03-dependent transport systems (Fig. 1): i) a putative alkalinizing (Na + HCO3)/C1 exchanger (although the role of Cl in this exchanger is still at issue) (Aickin and Brading, 1984; Aalkjaer and Mulvany, 1988); and ii) an acidifying Cl/HCO3 exchanger. While these exchangers are important for determining steady state pHi (Aalkjaer and Cragoe, 1988; Boyarsky et al., 1988a; Wray, 1988; Kikeri et al., 1990; Putnam and Grubbs, 1990), defending pHi against acid/base disturbances (Aalkjaer and Cragoe, 1988; Boyarsky et al., 1988b; Putnam, 1990) and mediating cellular responses to external signals (Berk et al., 1987; Ganz et al., 1989), only the Na/H exchanger has been extensively studied in regard to the factors which regulate its activity. In fact, the regulation of the HCO3-dependent transport systems is poorly studied in any cell.
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© 1991 Plenum Press, New York
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Putnam, R.W., Douglas, P.B., Dewey, D. (1991). Control of HCO3-Dependent Exchangers by Cyclic Nucleotides in Vascular Smooth Muscle Cells. In: Moreland, R.S. (eds) Regulation of Smooth Muscle Contraction. Advances in Experimental Medicine and Biology, vol 304. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6003-2_39
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DOI: https://doi.org/10.1007/978-1-4684-6003-2_39
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