Abstract
Serum levels of tryptophan (Tip) and 5-hydroxytryptophan (5-HTP) were measured in the mother at birth, by normal delivery or cesarean section, on days 1 and 3 postpartum, and in the cord blood of the fetus-newborns. Decreases in Trp and 5-HIP levels during delivery were noted. Conversely, Trp levels in the cord blood of fetus-newborns were significantly higher than those of their mothers, and 5-HTP levels also showed a tendency to increase, whereas on day 1 post-partum Trp values were lower than those in fetal cord, but higher than those during spontaneous delivery. On day 3 post-partum, serum Trp levels were higher than those during spontaneous delivery, but similar to those on day 1. 5-HTP values tended to decrease with respect to those of day 1.Serum Trp and 5-HTP concentrations decreased significantly on day 1 post-partum after cesarean section, but increased on day 3, demonstrating that maternal Trp was being consumed during delivery. A major release of prolactin in serum on days 1 and 3 post-partum there was in women with normal delivery, revealing a correlation between Trp and prolactin in the first few days after birth, in relation to different conditions of delivery
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References
P.J. Knott and G.Curzon, Free tryptophan in plasma and brain tryptophan metabolism, Nature London 239, 452–453 (1972).
A. Tagliamonte, G. Biggio, L. Vargiu, and G.L. Gessa, Free tryptophan in serum controls, brain tryptophan level and serotonin synthesis, Life Sci. 12’, 277–287 (1973).
C. Costa, A. Bettero, and G. Allegri, Rapid measurement of tryptophan, 5-hydroxytryptophan, serotonin and 5-hydroxyindoleacetic acid in human CSF by selective fluorescence and HPLC, Giorn. It. Chim. Clin. 12, 307–312 (1987).
A. De Antoni, N. Carretti, C. Costa, N. D’Antona, A. Bertolin, and G. Allegri, Triptofano totale e libero nel siero di madri al momento del parto e dei rispettivi neonati, Giorn. Il. Chim. Clin. 5, 71–77 (1980)
A.R. Genazzani, F. Petraglia, F. Facchinetti, P.A. Galli, and A. Volpe, Lack of beta-endorphin plasma level rise in oxytocin-induced labor, Gynecol Obstet Invest. 19, 130–134 (1985)
A. Laviano, C. Cangiano, A. Fava, M. Muscaritoli, G. Mulieri, and F. Rossi Fanelli, Peripherally injected IL-1 induces anorexia and increases brain tryptophan concentrations, in: Tryptophan. Serotonin and Melatonin: Basic Aspects and Applications, edited by G. Huether, W. Kochen, T.J. Simat and H. Steinhart (Plenum Publishers, New York, 1999), pp. 105–108.
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Carretti, N., Bertazzo, A., Comai, S., Costa, C.V.L., Allegri, G., Petraglia, F. (2003). Serum Tryptophan And 5-Hydroxytryptophan At Birth And During Post-Partum Days. In: Allegri, G., Costa, C.V.L., Ragazzi, E., Steinhart, H., Varesio, L. (eds) Developments in Tryptophan and Serotonin Metabolism. Advances in Experimental Medicine and Biology, vol 527. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0135-0_90
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DOI: https://doi.org/10.1007/978-1-4615-0135-0_90
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