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Ultrasound Contrast Agents: Development of the Field and Current Status

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Contrast Agents II

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 222))

Abstract

Design, preparation and application of microbubbles as ultrasound contrast agents are discussed. Modern generation of ultrasound contrast materials can be prepared as aqueous dispersions of micron-size bubbles of water-insoluble gas (e.g., perfluorocarbon) coated with a thin shell made of protein, lipid or polymer. Such microbubbles can be injected intravenously for imaging blood flow and tissue and organ delineation and perfusion. Microbubbles can be outfitted with targeting ligands for selective contrasting of the areas of disease. Microbubbles can be selectively destroyed in the ultrasound field. So, if a drug or plasmid DNA is attached to a microbubble, selective release into the insonified areas of the body can be achieved for drug delivery or gene therapy. Several ultrasound contrast agents have received approval for clinical use so far. Their widespread application will allow rapid and inexpensive diagnostics of tissue perfusion abnormalities and location of tumor metastases.

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  1. Department of Internal Medicine, University of Virginia Cardiovascular Division, Hospital Drive, Cobb Hall, Room 1026, Charlottesville, VA, 22908-0158

    Alexander L. Klibanov

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  1. Alexander L. Klibanov
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  1. International Project Management Therapeutics, Schering AG, 13342, Berlin, Germany

    Werner Krause

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Klibanov, A.L. (2002). Ultrasound Contrast Agents: Development of the Field and Current Status. In: Krause, W. (eds) Contrast Agents II. Topics in Current Chemistry, vol 222. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-46009-8_3

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  • DOI: https://doi.org/10.1007/3-540-46009-8_3

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