Overview
- Brings together all of the latest research by top researchers on molecular mechanisms in the pathogenesis of INS
- Represents one putative pathogenetic molecule in each chapter and reviews its role, mechanism, and prospects as a biomaker or for new drugs
- Provides valuable reading for physicians, pediatricians, nephrologists, and individuals researching nephrotic syndrome
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About this book
This comprehensive book reviews our current state of knowledge about the pathogenesis of idiopathic nephrotic syndrome (INS), which comprises a heterogeneous group of diseases with distinct histological characteristics, such as minimal-change nephrotic syndrome (MCNS), focal segmental glomerulosclerosis (FSGS), and idiopathic membranous nephropathy (IMN). As the word “idiopathic” indicates, the pathogenesis of INS remains unclear. Historically, T-cell dysfunction has been thought to play an important part in the pathogenesis of MCNS, while circulating vascular permeabilities have been believed to induce proteinuria in FSGS. The book further describes recent advances in molecular biology, which have allowed us to speculate on the interactions between visceral glomerular epithelial cells (podocytes) and the relative significance of several molecules in the pathogenesis of INS, such as reactive oxygen species, nuclear factor-kappa B, CD80, angiopoietin-like 4, cardiotrophin-like cytokine-1, and M-type phospholipase A2 receptor. The normally rapid pace of scientific progress occasionally devolves into a state of chaos, and the pathogenetic research on INS is one such case. This volume will help researchers and scientists to collaborate, share resources, and expedite the design of protocols to evaluate the putative factors.
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Table of contents (13 chapters)
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Front Matter
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Introduction
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Front Matter
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Minimal-Change Nephrotic Syndrome (MCNS)
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Front Matter
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Focal Segmental Glomerulosclerosis (FSGS)
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Front Matter
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Idiopathic Membranous Nephropathy (IMN)
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Front Matter
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Treatment in Idiopathic Nephrotic Syndrome
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Front Matter
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Editors and Affiliations
Bibliographic Information
Book Title: Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome
Editors: Kazunari Kaneko
DOI: https://doi.org/10.1007/978-4-431-55270-3
Publisher: Springer Tokyo
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer Japan 2016
Hardcover ISBN: 978-4-431-55269-7Published: 25 November 2015
Softcover ISBN: 978-4-431-56279-5Published: 23 August 2016
eBook ISBN: 978-4-431-55270-3Published: 26 October 2015
Edition Number: 1
Number of Pages: VIII, 240
Number of Illustrations: 5 b/w illustrations, 16 illustrations in colour
Topics: Nephrology, Urology, Molecular Medicine